COX-1-IN-5 is a highly selective COX-1 inhibitor, demonstrating an IC50 of 1 nM for COX-1 and greater than 0.1 μM for COX-2, thereby showing over 1000-fold selectivity for COX-1. This compound exhibits significant anti-inflammatory, antipyretic, analgesic, antithrombotic, and potential anti-cancer properties. COX-1-IN-5 is suitable for investigating COX-mediated diseases, including inflammatory conditions and pain. Additionally, when radiolabeled with 11C, it serves as a selective PET tracer for in vivo imaging of COX-1 distribution and target engagement.
COX-1-IN-5 is a highly selective COX-1 inhibitor, demonstrating an IC50 of 1 nM for COX-1 and greater than 0.1 μM for COX-2, thereby showing over 1000-fold selectivity for COX-1. This compound exhibits significant anti-inflammatory, antipyretic, analgesic, antithrombotic, and potential anti-cancer properties. COX-1-IN-5 is suitable for investigating COX-mediated diseases, including inflammatory conditions and pain. Additionally, when radiolabeled with 11C, it serves as a selective PET tracer for in vivo imaging of COX-1 distribution and target engagement.
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