CRBN-6-5-5-VHL

Name: CRBN-6-5-5-VHL
Brand: Adooq Bioscience
SKU: A23963
Rating: 5 (288 reviews)

Catalog No.: A23963

PROTAC CRBN Degrader

CRBN-6-5-5-VHL is a potent and selective VHL-based PROTAC degrader targeting cereblon (CRBN), with a DC₅₀ of 1.5 nM. It selectively degrades CRBN without affecting neo-substrates IKZF1 and IKZF3.

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CRBN-6-5-5-VHL 2362575-45-7 PROTAC CRBN Degrader

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Grouped product items
Size	Price	Stock
5mg	$315.00	In stock
10mg	$543.00	In stock
50mg	$1,610.00	In stock
100mg	$3,150.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	CRBN-6-5-5-VHL is a potent and selective VHL-based PROTAC degrader targeting cereblon (CRBN), with a DC₅₀ of 1.5 nM. It selectively degrades CRBN without affecting neo-substrates IKZF1 and IKZF3.

Product Information

Catalog Num	A23963
Formula	C51H69N7O10S
Molecular Weight	972.20
CAS Number	2362575-45-7
SMILES	O=C(N1C(CCC2=O)C(N2)=O)C(C(C1=O)=CC=C3)=C3NCCCCCCOCCCCCOCCCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H]4O)[C@@H](C4)C(NCC5=CC=C(C(SC=N6)=C6C)C=C5)=O)=O)=O
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂