DAPT (GSI-IX)

Catalog No.: A10288

Gamma secretase inhibitor

DAPT (GSI-IX)

DAPT (GSI-IX) Chemical Structure

CAS NO. 208255-80-5

DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.

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5 mg

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10 mg

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25 mg

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50 mg

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100 mg

Regular Price: $400.00

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10mM * 1mL in DMSO

Regular Price: $94.00

Special Price $75.20

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  • Paul Mark Medina, .et al. Revealing the anticancer potential of candidate drugs in vivo using Caenorhabditis elegans mutant strains, Transl Oncol, 2021, Jan;14(1):100940 PMID: 33221682
  • Tatsuya Usui, .et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture, Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386

Biological Activity

DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
Targets
Aβ (HEK 293 cells) γ secretase(Aβ) (HEK 293 cells)
20 nM20 nM
In vitro (25°C) DMSO 79 mg/mL (182.67 mM)
Water Insoluble
Ethanol 46 mg/mL (106.36 mM)
In vivo 4% DMSO+corn oil 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 23.12 mL 115.61 mL 231.21 mL
0.5 mM 4.62 mL 23.12 mL 46.24 mL
1 mM 2.31 mL 11.56 mL 23.12 mL
5 mM 0.46 mL 2.31 mL 4.62 mL

*The above data is based on the productmolecular weight 432.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10288
Actions Inhibitor
CAS No. 208255-80-5
Formula C23H26F2N2O4
M. Wt 432.5
Purity >98%
Synonyms GSIIX
SMILES C[[email protected]@H](C(=O)N[[email protected]@H](C1=CC=CC=C1)C(=O)OC(C)(C)C)NC(=O)CC2=CC(=CC(=C2)F)F
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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