DBCO-NHCO-PEG13-NHS ester is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling the efficient formation of covalent linkages. Its application in PROTAC development supports targeted protein degradation studies, making it a valuable tool in chemical biology and drug discovery research.
DBCO-NHCO-PEG13-NHS ester is a PEG-based PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling the efficient formation of covalent linkages. Its application in PROTAC development supports targeted protein degradation studies, making it a valuable tool in chemical biology and drug discovery research.
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