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DBCO-PEG12-acid

PROTAC Linkers

DBCO-PEG12-acid is a polyethylene glycol (PEG)-based linker utilized in the synthesis of Proteolysis Targeting Chimera (PROTAC) molecules. Featuring a DBCO ( dibenzocyclooctyne) moiety, it enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This reagent is integral for developing novel bifunctional agents aimed at targeted protein degradation, enhancing research in pharmacology and therapeutic applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2754384-72-8
Applications	PROTAC Linkers
Formula	C₄₆H₆₈N₂O₁₆
Molecular Weight	905.04
SMILES	O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCC(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.