Catalog No.
Product Name
Application
Product Information
Citations
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DNA Synthesis Substrate
5-Fluoro-2′-deoxy-UTP is a nucleotide analog primarily utilized as a substrate in DNA synthesis. This compound incorporates into DNA strands, allowing researchers to study nucleotide incorporation and the effects of fluorinated nucleotides on replication and genetic stability. It is widely used in molecular biology applications, including the synthesis of modified oligonucleotides and in various labeling techniques for DNA analysis. -
DNA Synthesis Activator
Isorhamnetin 3-gentiobioside is a flavonoid known for its role as a DNA synthesis activator, particularly in MCF-7 human breast cancer cells, exhibiting an EC50 of 3.1 μg/mL. This compound demonstrates significant biological activity, promoting cell proliferation and exhibiting ABTS radical scavenging activity with an IC50 of 33.43 μg/mL. It serves as a valuable reagent for investigating the regulatory mechanisms underlying cancer biology. -
DNA/RNA Synthesis Inhibitor
Methotrexate α-tert-butyl ester is an antimetabolite and antifolate compound that acts as a potent inhibitor of DNA and RNA synthesis. It demonstrates significant anti-tumor activity by effectively reducing tumor growth in HT1080 tumor-bearing mouse models. This compound is also utilized for its immunosuppressive and antineoplastic properties in various research applications. -
DNA Synthesis Inhibitor
Cytarabine triphosphate (Ara-CTP) is a competitive inhibitor of DNA synthesis, serving as an active metabolite of Cytarabine. This compound plays a crucial role in cellular mechanisms by disrupting normal DNA replication processes. Its intracellular levels are valuable for predicting the chemosensitivity of leukemic blasts to Cytarabine, making it a significant biomarker in the treatment of leukemia and related hematological disorders. -
DNA Synthesis Inhibitor
Cytembena is a potent inhibitor of DNA synthesis, primarily targeting replicative DNA processes, purine biosynthesis, and tetrahydrofolate formylase activity. Its biological activity demonstrates significant anti-cancer effects, particularly in the treatment of ovarian and breast cancer, as well as providing pain relief in cases of skeletal metastases. This compound is valuable in research applications focused on cancer therapeutics and the mechanisms of DNA replication and repair. -
DNA/RNA Synthesis Chemical
5-Propargylamino-3'-azidomethyl-dUTP functions as a nucleoside analogue in DNA and RNA synthesis. This reagent is compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC), making it suitable for bioconjugation applications. Researchers can utilize this compound in diverse applications, including DNA synthesis and sequencing, owing to its azide and alkyne functionalities that facilitate modular addition of biomolecules. -
DNA/RNA Synthesis Inhibitor
Riddelline is a pyrrolizidine alkaloid that functions as a potent inhibitor of DNA and RNA synthesis. It exhibits significant genotoxic properties by inducing elevations in unscheduled DNA synthesis and S-phase synthesis in rat liver models. This compound is utilized in research to study the mechanisms of genotoxicity and its implications in cellular processes and carcinogenesis. -
DNA/RNA Synthesis Inhibitor
Bromochloroacetonitrile, a potent DNA/RNA synthesis inhibitor, exhibits direct mutagenic activity and can induce DNA strand breakage. This compound serves as a valuable tool in research focused on understanding DNA damage mechanisms and the effects of mutagens on genetic material. Its ability to disrupt nucleic acid synthesis makes it relevant for studies in genotoxicity and cancer research. -
DNA/RNA Synthesis
RNAP-σ interaction inhibitor-1 is a specific inhibitor of RNA polymerase-sigma factor interactions, playing a crucial role in DNA and RNA synthesis. This compound demonstrates significant antibacterial activity against Streptococci, with minimal inhibitory concentration (MIC) values ranging from 1 to 2 µg/mL. It is a valuable tool for research applications focused on bacterial transcription mechanisms and the development of novel antibacterial agents. -
HBV DNA Synthesis Inhibitor
LB80317 is an active metabolite of LB80380 that functions as a potent inhibitor of HBV DNA synthesis, exhibiting an EC50 of 0.5 μM. This compound demonstrates antiviral activity, making it a promising candidate for the treatment of chronic hepatitis B. Its ability to inhibit viral replication supports its potential utility in HBV research and therapeutic applications. -
DNA Synthesis Inhibitor
Alldimycin A is an anthracycline compound that functions as a potent inhibitor of DNA and RNA synthesis. It demonstrates significant anti-proliferative activity against murine leukemic L1210 cells, exhibiting IC50 values of 0.05 μg/mL for growth inhibition, 0.92 μg/mL for RNA synthesis, and 0.47 μg/mL for DNA synthesis. Alldimycin A is valuable for research applications in cancer biology and the study of nucleic acid metabolism. -
DNA/RNA Synthesis Inhibitor
Ulicyclamide is a cytotoxic cyclic peptide that functions as a DNA and RNA synthesis inhibitor. Isolated from the tunicate Lissoclinum patella, Ulicyclamide effectively inhibits nucleic acid synthesis in leukemia cells. This compound is primarily utilized in research focused on leukemia and the underlying mechanisms of nucleic acid metabolism in cancer biology. -
DNA Synthesis Inhibitor
Teloxantrone is a potent DNA synthesis inhibitor with an IC50 of 0.33 μM. This compound exhibits significant antitumor activity and is particularly relevant in the study of colorectal cancer. Its ability to interfere with DNA replication makes it a valuable tool for cancer research and therapeutic investigations. -
DNA/RNA Synthesis Inhibitor
Ledoxantrone is a potent inhibitor of DNA and RNA synthesis, specifically targeting DNA helicases with an IC50 of 0.17 μM. This compound demonstrates significant biological activity against cancer cells and is utilized in research focusing on prostate cancer. Its mechanism of action provides valuable insights into the role of DNA repair and replication in oncogenesis. -
DNA Synthesis/HSV/HIV-1 Inhibitor
16,16-Dimethyl prostaglandin A1 is a prostaglandin analog that primarily inhibits DNA synthesis. It demonstrates significant antiviral activity by reducing viral replication in both herpes simplex virus (HSV) and HIV-1 infection models. This compound serves as a valuable tool for research focused on cancer biology and viral pathogenesis. -
rRNA Synthesis Inhibitor
NusB-IN-1 is a potent inhibitor of bacterial rRNA synthesis, demonstrating significant antimicrobial activity against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Staphylococcus aureus (VRSA). This compound serves as a valuable tool in microbiological research and drug development targeting bacterial RNA synthesis mechanisms. Additionally, NusB-IN-1 features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, facilitating its use in click chemistry applications. -
DNA/RNA Synthesis
RNAP-σ interaction inhibitor-2 targets the interaction between RNA polymerase and sigma factors, effectively disrupting transcription in bacterial systems. It demonstrates notable antimicrobial activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 2 µg/mL. This compound is a valuable tool for studying DNA/RNA synthesis and exploring the mechanisms of bacterial gene regulation. -
DNA Synthesis Inhibitor
7U85 is a potent DNA synthesis inhibitor that targets the processes involved in DNA replication. Its primary mechanism disrupts nucleotide incorporation, thereby impeding cell proliferation. This compound demonstrates significant potential for research applications in breast cancer studies, offering insights into tumor growth and treatment resistance mechanisms. -
DNA Synthesis Inhibitor
Miboplatin (DWA-2114R) is a platinum-based compound that functions as a DNA synthesis inhibitor. It effectively diminishes the template activity of both prokaryotic and eukaryotic DNA polymerases, making it valuable for research focused on DNA replication processes. This compound is useful in studies exploring DNA damage response, cancer biology, and potential therapeutic applications in oncology. -
vRNA/cRNA Synthesis Product
pppApG is a pivotal nucleotide involved in the synthesis of both viral RNA (vRNA) and complementary RNA (cRNA). This compound serves as a critical starting substrate in the assembly of viral genomes, making it essential for influenza virus research and related studies. Its application supports investigations into viral replication mechanisms and the development of antiviral strategies. -
RNA Synthesis Inhibitor
Nitracrine dihydrochloride hydrate is an RNA synthesis inhibitor that covalently and reversibly binds to DNA, forming covalent adducts within biological systems. This 1-nitroacridine derivative exhibits potent hypoxia-selective activity in vitro and serves as an effective antitumor agent. Its cytotoxic properties extend to a wide range of cell types, making it a valuable compound for cancer research and studies focusing on DNA-targeting agents. -
DNA/RNA Synthesis Chemical
5-Propargylamino-3'-azidomethyl-dCTP is a nucleoside analog utilized primarily in DNA and RNA synthesis. This compound features an azide functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted azide-alkyne cycloaddition (SPAAC) with alkyne-containing molecules. Its chemical properties make it a valuable tool for applications in click chemistry, particularly in the development of bioconjugates and in DNA sequencing technologies. -
DNA/RNA Synthesis Inhibitor
Ara-ATP is a structural analog of ATP that functions as an inhibitor of poly(A) polymerase activity through competitive interaction with ATP. This inhibition disrupts the biosynthesis of RNA, making Ara-ATP valuable for studies on RNA processing and regulation. It is particularly useful in examining mechanisms of gene expression and RNA metabolism in various cellular contexts. -
DNA Synthesis Inhibitor
2-Keto-D-galactose, also known as D-Galactosone, functions as a potent inhibitor of DNA synthesis. It displays significant biological activity by inhibiting the proliferation of Ehrlich ascites tumor cells in vitro, making it a valuable reagent for cancer research and studies involving cell growth regulation. This compound can be utilized to investigate the mechanisms of DNA synthesis disruption and its effects on tumor cell dynamics. -
RNA Synthesis Inhibitor
Nitracrine hydrochloride is an RNA synthesis inhibitor that targets hypoxic cancer cells through its platinum-based structure. It demonstrates significant cytotoxicity against the Chinese hamster ovary cell line AA8 under low oxygen conditions, primarily by forming covalent adducts with DNA. This compound's mechanism involves reductive metabolism, leading to the formation of alkylating agents that enhance its reactivity with DNA. By inhibiting RNA synthesis, Nitracrine hydrochloride contributes to its overall anti-tumor efficacy, making it a valuable reagent for cancer research. -
DNA/RNA Synthesis Chemical
DMT-dU-CE Phosphoramidite is a versatile nucleotide building block utilized in DNA and RNA synthesis. This compound serves as an essential reagent for incorporating 5-(Dimethoxytrityl)-modified deoxyuridine into oligonucleotide sequences. Its application extends to DNA sequencing and various molecular biology techniques, facilitating precise synthesis of nucleic acids for research and therapeutic purposes. -
DNA Synthesis Inhibitor
Methyl 3-oxodecanoate is a DNA synthesis inhibitor targeting protein synthesis at the level of translation initiation. This compound exhibits biological activity against human pathogens, including fluorescent haplophyllum and its culture supernatant. It serves as a valuable reagent for research applications focused on understanding virulence factors and mechanisms of DNA synthesis inhibition. -
DNA Synthesis Substrate
5-Fluoro-2′-deoxy-UTP sodium serves as a nucleotide substrate in DNA synthesis. It incorporates into DNA strands during replication and transcription, providing a means to study nucleic acid processes and investigate mutations. This reagent is essential for applications such as polymerase chain reactions and other molecular biology techniques that require modified nucleotides. -
DNA/RNA Synthesis Inhibitor
F-ara-EdU is a potent DNA and RNA synthesis inhibitor that functions as a valuable probe for monitoring cell proliferation and DNA replication. This highly stable compound selectively binds to DNA and RNA in cells, enabling the quantification of DNA synthesis rates. Additionally, F-ara-EdU is instrumental in investigating the mechanisms underlying DNA repair and damage, making it an essential tool for researchers studying cellular responses to genomic instability. -
DNA Synthesis Inhibitor
Cytarabine 5’-monophosphate is a DNA synthesis inhibitor that acts as a metabolite of the nucleoside analog Cytarabine. It is phosphorylated by deoxycytidine kinase and subsequently incorporated into DNA by DNA polymerase α, effectively reducing the rate of DNA synthesis. At a concentration of 15 mM, it shows inhibitory effects on nuclear and mitochondrial DNA replication in Saccharomyces cerevisiae. Additionally, at doses ranging from 3.5 to 75.1 mg/kg, it contributes to improved survival rates in L1210 leukemia mouse models, making it a valuable compound for cancer research applications. -
DNA Synthesis Terminator
3'-O-(2-Nitrobenzyl)-dATP is a photolabile DNA synthesis terminator that specifically targets the 3'-end of growing DNA strands. Its incorporation results in the cessation of DNA synthesis in a base-specific manner. Upon exposure to UV light, the 3'-protecting nitrobenzyl group is efficiently removed, allowing for the reinitiation of DNA synthesis. This compound is particularly valuable in the development of the Base Addition Sequencing Scheme (BASS), facilitating iterative stop-start cycles in DNA synthesis. -
DNA/RNA Synthesis Inhibitor
Ledoxantrone trihydrochloride is a DNA/RNA synthesis inhibitor that targets DNA helicases, exhibiting an IC50 of 0.17 μM. This compound is primarily utilized in cancer research, particularly in studies related to prostate cancer, to explore its effects on cellular proliferation and gene expression pathways. -
DNA Synthesis Inhibitor
Quinoprazine is a potent inhibitor of DNA synthesis, specifically targeting Vaccinia virus with an IC50 value of 10 μM. This compound demonstrates significant antimalarial activity against Plasmodium berghei and exhibits antiprion efficacy, effectively reducing levels of the pathogenic protein PrPSc. Quinoprazine's diverse biological activities make it a valuable tool for research in virology, parasitology, and prion disease studies. -
Usherin Synthesis Promotor
Ultevursen (QR-421a) is a single-stranded RNA oligonucleotide that acts as a splice-switching agent, designed to promote the skipping of exon 13 in the USH2A gene, which encodes usherin. This mechanism aims to halt vision loss associated with retinitis pigmentosa caused by mutations within this exon. Ultevursen has potential applications in gene therapy and research focused on treatments for genetic retinal diseases.
