Nucleoside Antimetabolite/Analog

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  1. Pyrimidine Nucleoside Analog

    4-Chloro-7-(2-deoxy-3,5-bis-O-(p-toluoyl)-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog that targets nucleic acid synthesis. This compound exhibits significant biological activities including the inhibition of DNA and RNA synthesis, as well as antiviral and immunomodulatory effects. It is valuable in biochemical research and may be applied in the development of therapeutic strategies for various diseases, including cancer and viral infections.
  2. Product of γ-Glutamylputrescine

    Gamma-glutamyl-gamma-aminobutyraldehyde is an oxidation product of γ-glutamylputrescine, primarily functioning as an intermediate in polyamine metabolism. This compound exhibits notable biological activity related to cellular metabolism and can be utilized in research investigating the roles of polyamines in growth, cell differentiation, and neuroprotection. Its applications extend to studying neurochemical pathways and potential implications in neurodegenerative conditions.
  3. Purine Nucleoside Analog

    5-Nitro-1-(3-azido-3-deoxy-β-D-ribofuranosyl)-2(1H)-pyridinone is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This versatility makes it a valuable tool in chemical biology and medicinal chemistry research.
  4. Antioxidant

    3'-Azido-3'-deoxyguanosine is a chemical reagent with significant antioxidant properties, exhibiting effective free radical scavenging activity. It demonstrates potent activity against DPPH radicals and shows antioxidant capacity in β-carotene-linoleate model systems. Additionally, this compound serves as a versatile click chemistry reagent, possessing an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions. It can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups, making it valuable for various biochemical and bioconjugation applications.
  5. Purine Nucleoside Analog

    2’-Deoxy-2’-fluoro-5-methyl-4’-thio-β-D-arabino uridine is a purine nucleoside analog that acts as a potent inhibitor of DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting nucleic acid metabolism. It is especially useful in cancer research for exploring therapeutic strategies and understanding the molecular mechanisms underlying tumor growth.
  6. Purine Nucleoside Analog

    2’,3’,5’-Tri-O-benzoyl-4-thiouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms are primarily due to the inhibition of DNA synthesis and the induction of apoptosis. This reagent is valuable for research applications aimed at understanding the biochemical pathways of cancer and developing potential therapeutic strategies.
  7. Purine Nucleoside Analog

    3'-Deoxy-N6-isopentenyl adenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. This compound is valuable for research applications aimed at understanding and developing novel therapeutic strategies in oncology.
  8. Purine Nucleoside Analog

    3'-O-Acetylthymidine is a purine nucleoside analog that exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. This compound functions primarily by inhibiting DNA synthesis and inducing apoptosis, making it a valuable tool in cancer research. Its properties are useful for studying the mechanisms of tumor cell proliferation and survival, contributing to the development of targeted cancer therapies.
  9. Purine Nucleoside Analog

    7-(Butyn-2-yl)-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a click chemistry reagent due to its alkyne functionality, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This dual functionality makes it a valuable tool for both therapeutic and research applications.
  10. Guanosine Analog

    9-(β-D-Xylofuranosyl)guanine is a guanosine analog that exhibits immunostimulatory properties. This compound can induce type I interferons in various animal models, leading to potent antiviral effects. The biological activity of 9-(β-D-Xylofuranosyl)guanine is closely linked to the activation of Toll-like receptor 7 (TLR7), making it a valuable tool for research in antiviral therapies and immune response modulation.
  11. Purine Nucleoside Analog

    2'-O-Phthalimidopropyl uridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications aimed at understanding and developing therapies for various malignancies.
  12. Purine Nucleoside Analog

    N4-Benzoyl-5’-O-(4,4-dimethoxytrityl)-3’-deoxy cytidine is a purine nucleoside analog with significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable compound for cancer research. This reagent is useful for studies focused on nucleoside analogs and their potential therapeutic applications in oncology.
  13. Purine Nucleoside Analog

    5'-O-(4,4'-Dimethoxytrityl)-5-methoxyuridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is suitable for studies focused on understanding and developing therapeutic strategies for treating various hematological cancers.
  14. Purine Nucleoside Analog

    2'-O-Hexadecanyl-2-aminoadenosine is a purine nucleoside analog with significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms primarily involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. This compound can be utilized to study the effects of purine metabolism and nucleoside transport in various cellular contexts.
  15. Purine Nucleoside Analog

    5′-Deoxy-5′-iodo-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focusing on cancer biology and therapeutic development.
  16. Purine Nucleoside Analog

    5-Fluoro-4’-thiouridine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. This reagent is suitable for studies focused on nucleoside analogs and their potential applications in oncology.
  17. Purine Nucleoside Analog

    2’-β-C-Ethynylcytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, 2’-β-C-Ethynylcytidine serves as a click chemistry reagent, featuring an alkyne group capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating bioconjugation applications in chemical biology research.
  18. Purine Nucleoside Analog

    8-Chloroinosine is a purine nucleoside analogue that exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. This compound is suitable for research applications focused on elucidating the therapeutic potential of purine analogs in cancer treatment.
  19. Purine Nucleoside Analog

    4'-Thioinosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for research in cancer biology and therapeutic development. This compound is instrumental in studying the effects of nucleoside analogs on cellular processes and can aid in the exploration of new treatment strategies for malignancies.
  20. Purine Nucleoside Analog

    6-Amino-1,2-dihydro-2-β-D-ribofuranosyl-4H-pyrazolo[3,4-d]pyrimidin-4-one is a purine nucleoside analogue that exhibits significant antitumor activity, particularly in the treatment of indolent lymphoid malignancies. This compound primarily functions by inhibiting DNA synthesis and inducing apoptosis in cancer cells, making it a valuable tool for cancer research and therapeutic development. Its diverse biological activities are essential for exploring novel approaches in oncological studies.
  21. Purine Nucleoside Analog

    5-Aminocarbonylmethyl-2-thiouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological effects primarily stem from the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is valuable for research applications focused on cancer biology and therapeutic development strategies targeting nucleoside metabolism.
  22. Guanosine Analog

    N2-iso-Butyroyl-5’-O-DMT-3’-O-(methoxyethyl)guanosine is a guanosine analog that primarily targets Toll-like receptor 7 (TLR7) to elicit biological responses. It exhibits immunostimulatory activity and has been demonstrated to induce type I interferons in various animal models, contributing to its antiviral effects. This compound serves as a valuable tool for research in the fields of immunology and virology, particularly in studies focused on immune response modulation and antiviral therapies.
  23. Uridine Analog

    1-(β-D-Xylofuranosyl)uracil functions as a uridine analog, targeting pathways associated with nucleoside metabolism. This compound exhibits potential antiepileptic effects and is valuable for investigating anticonvulsant and anxiolytic activities. Additionally, it serves as a tool for the development of novel antihypertensive agents, making it relevant for various biochemical and pharmacological research applications.
  24. Cytidine Analog

    N4,N4-Dimethylarabinocytidine is a cytidine nucleoside analog that primarily targets DNA methyltransferases. This compound exhibits potential anti-metabolic and anti-tumor activities, making it a valuable tool for cancer research. Its ability to inhibit DNA methylation contributes to its utility in studies focused on epigenetics and gene regulation.
  25. Purine Nucleoside Analog

    N2-iBu-5’-O-DMTr-2’-O-hexadecanyl guanosine 3’-CED phosphoramidite is a purine nucleoside analog designed for use in molecular biology applications. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, primarily through mechanisms such as DNA synthesis inhibition and apoptosis induction. It serves as an essential reagent for researchers investigating the therapeutic potential of nucleoside analogs in cancer treatment.
  26. Nucleoside Metabolite

    N2-Succinyl-L-arginine is a nucleoside metabolite that serves as a substrate for various enzymatic reactions. This compound is involved in the metabolic pathways of arginine and contributes to the regulation of nitric oxide synthesis. Its activity is important for studies related to vascular biology, cancer research, and metabolic disorders, making it a valuable reagent for investigating cellular signaling and metabolic processes.
  27. Purine Nucleoside Analog

    3’-Deoxy-3’-azido-isocytidine is a purine nucleoside analog that exhibits notable antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action includes the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a versatile click chemistry reagent, containing an azide group that is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. These properties make it valuable for various research applications in chemical biology and medicinal chemistry.
  28. Purine Nucleoside Analog

    2-Thiopseudouridine is a purine nucleoside analog with significant potential in cancer research. It exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. The compound's anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for studying cancer biology and developing therapeutic strategies.
  29. Thymidine Analog

    5-N-Boc-aminomethyluridine is a thymidine analog known for its incorporation into replicated DNA. This compound exhibits insertional activity, making it valuable for cellular labeling and tracking DNA synthesis in various biological research applications. Its unique properties facilitate the study of nucleic acid metabolism and cellular processes.
  30. Purine Nucleoside Analog

    2’-O-Acetyl-5’-O-(p-toluoyl)-3’-deoxy-3’-fluoro-5-fluorouridine is a purine nucleoside analog with significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is essential for studies aimed at developing therapies for hematological malignancies and understanding the biochemical pathways involved in tumor progression.
  31. Purine Nucleoside Analog

    5-Methyl-2-thio-xylo-uridine is a purine nucleoside analog that exhibits broad antitumor activity primarily against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound aids in the study of therapeutic strategies for various hematological cancers, contributing to the understanding of cellular responses and treatment efficacy.
  32. Purine Nucleoside Analog

    2’-Deoxy-2’-fluoroarabino-O6-methyl inosine is a purine nucleoside analog that exerts its biological activity primarily through the inhibition of DNA synthesis. This compound demonstrates significant antitumor effects, making it particularly relevant in the study of indolent lymphoid malignancies. Its mechanisms of action include the induction of apoptosis, which further enhances its potential in cancer research applications.
  33. Purine Nucleoside Analog

    N6-Benzoyl-3'-fluoro-2',3'-dideoxyadenosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanism of action involves the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research. This compound is suitable for studies aimed at exploring its potential therapeutic applications in oncology.
  34. Purine Nucleoside Analog

    5-Azidomethyl-2’-beta-methyl uridine is a purine nucleoside analog that demonstrates significant antitumor activity, particularly against indolent lymphoid malignancies. Its mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis. In addition, this compound serves as a versatile click chemistry reagent, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with alkyne-containing molecules, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This makes it an invaluable tool for chemical biology and medicinal chemistry applications.
  35. Purine Nucleoside Analog

    8-Aza-7-deazguanosine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its biological mechanisms include the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool for cancer research and therapeutic exploration. This compound is suitable for studies aimed at understanding the molecular pathways involved in tumorigenesis and for developing potential anticancer strategies.
  36. Purine Nucleoside Analog

    N4-Benzoyl-2'-deoxy-5'-O-DMTr-2'-fluoro-5-methylcytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly in the treatment of indolent lymphoid malignancies. Its primary mechanisms of action involve inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound serves as a valuable tool for cancer research, enabling the study of nucleoside metabolism and the development of novel therapeutic strategies.
  37. Cytidine Analog

    5’(R)-C-Methylcytidine is a synthetic cytidine nucleoside analog that inhibits DNA methyltransferases. This compound exhibits significant anti-metabolic and anti-tumor activities, making it a valuable tool in cancer research. Its ability to interfere with DNA methylation processes provides insights into gene regulation and potential therapeutic interventions.
  38. Nucleoside Metabolite

    5-O-(1-Carboxyvinyl)-3-phosphoshikimic acid is a nucleoside metabolite that acts as an intermediate in the shikimic acid pathway. This compound is pivotal in the biosynthesis of aromatic amino acids and phenylpropanoids, contributing to essential metabolic processes in plants and microorganisms. Its utilization in research includes studies on metabolic engineering and the development of herbicides, as well as exploring its role in secondary metabolite production.
  39. Purine Nucleoside Analog

    2’-Deoxy-2’-fluoroinosine is a purine nucleoside analog that primarily inhibits DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting cellular proliferation. Its research applications include studying cancer cell biology and exploring therapeutic strategies for hematological cancers.
  40. Purine Nucleoside Analog

    9-(3-Deoxy-3-fluoro-β-D-ribofuranosyl)-6-(pyridine-4-yl)purine is a purine nucleoside analog that effectively inhibits DNA synthesis and induces apoptosis. This compound exhibits broad antitumor activity, particularly against indolent lymphoid malignancies. Its application in research underscores its potential as a therapeutic agent in cancer treatment strategies.
  41. Purine Nucleoside Analog

    2-Amino-6-chloropurine-9-beta-D-(2’-deoxy)riboside is a purine nucleoside analog that primarily inhibits DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, by inducing apoptosis and disrupting cellular proliferation. Its potential applications in cancer research make it a valuable tool for studying mechanisms of tumorigenesis and evaluating therapeutic strategies.
  42. Purine Nucleoside Analog

    2'-Deoxy-5,N4,N4-trimethylcytidine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer properties are primarily attributed to the inhibition of DNA synthesis and the induction of apoptosis. This compound serves as a valuable tool in cancer research, helping to elucidate mechanisms of tumor growth and potential therapeutic strategies.
  43. Nucleoside Metabolite

    Prostaglandin C2 is a nucleoside metabolite that plays a critical role in various physiological processes, including inflammatory responses and vascular regulation. This compound is involved in modulating cellular signaling pathways and may offer insights into the mechanisms underlying diseases linked to dysregulated prostaglandin levels. Prostaglandin C2 can be utilized in research applications focused on inflammation, cardiovascular health, and metabolic disorders.
  44. Purine Nucleoside Analog

    3’-Deoxy-5-methyluridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis in cancer cells. This compound is instrumental in various research applications aimed at understanding and developing therapies for malignancies resistant to conventional treatments.
  45. Purine Nucleoside Analog

    7-Cyclopropyl methyl-7,8-dihydro-8-oxo-9-(β-D-ribofuranosyl)guanine is a purine nucleoside analog known for its anticancer properties. This compound exhibits significant biological activity against indolent lymphoid malignancies, primarily through the inhibition of DNA synthesis and the induction of apoptosis. It represents a valuable tool for research in cancer therapeutics and the study of purine metabolism.
  46. Purine Nucleoside Analog

    MMT-2'-O-Methyl adenosine (n-bz) CED phosphoramidite is a purine nucleoside analog that serves as a versatile building block in oligonucleotide synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. It is primarily utilized in research focused on the development of novel therapeutics and the study of nucleic acid interactions.
  47. Purine Nucleoside Analog

    2'-Bromo-2'-deoxy-5-fluorouridine is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanism of action involves the inhibition of DNA synthesis, leading to the induction of apoptosis in cancer cells. This compound is valuable for research applications focusing on anticancer therapeutics and the study of nucleoside metabolism.
  48. Nucleoside Metabolite

    10-OPDA is a nucleoside metabolite that plays a pivotal role in nucleotide biosynthesis and cellular signaling. It participates in various biological processes, making it valuable for research applications in cell biology and metabolic studies. Investigating 10-OPDA can provide insights into nucleoside metabolism and related pathways in various organisms.
  49. Purine Nucleoside Analog

    2’,3’-Dideoxy-5-fluorocytidine is a purine nucleoside analog that exhibits substantial antitumor activity, particularly against indolent lymphoid malignancies. Its primary mechanisms of action involve the inhibition of DNA synthesis and the induction of apoptosis, making it a valuable tool in cancer research. This compound is instrumental for studies focusing on the development of targeted therapies and the understanding of nucleoside metabolism in tumor biology.
  50. Purine Nucleoside Analog

    3'-O-tert-Butyldimethylsilyl-5'-O-DMT-2'-deoxyadenosine is a purine nucleoside analog that targets DNA synthesis. This compound exhibits significant antitumor activity, particularly against indolent lymphoid malignancies, through mechanisms such as the inhibition of DNA replication and the induction of apoptosis. Its applications in cancer research make it a valuable tool for studying purine metabolism and therapeutic strategies in oncology.

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