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5-Nitro-1-(3-azido-3-deoxy-β-D-ribofuranosyl)-2(1H)-pyridinone

Purine Nucleoside Analog

5-Nitro-1-(3-azido-3-deoxy-β-D-ribofuranosyl)-2(1H)-pyridinone is a purine nucleoside analog that exhibits significant antitumor activity, particularly against indolent lymphoid malignancies. Its anticancer mechanisms involve the inhibition of DNA synthesis and the induction of apoptosis. Additionally, this compound serves as a click chemistry reagent, featuring an azide group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, and can also participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. This versatility makes it a valuable tool in chemical biology and medicinal chemistry research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2072145-26-5
Applications	Purine Nucleoside Analog
Formula	C₁₀H₁₁N₅O₆
Molecular Weight	297.22
SMILES	OC[C@@H]1[C@@H](N=[N+]=[N-])[C@@H](O)[C@H](N2C(C=CC([N+]([O-])=O)=C2)=O)O1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.