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- Yesuvadian R, .et al. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study., Biochem Biophys Res Commun., 2014, May 16;447(4):590-5 PMID: 24747079
Biological Activity
E 2012 is γ-secretase inhibitor.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.84 mL | 119.19 mL | 238.38 mL |
| 0.5 mM | 4.77 mL | 23.84 mL | 47.68 mL |
| 1 mM | 2.38 mL | 11.92 mL | 23.84 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.77 mL |
*The above data is based on the productmolecular weight 419.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A11393 |
|---|---|
| Actions | Modulator |
| CAS No. | 870843-42-8 |
| Formula | C25H26FN3O2 |
| M. Wt | 419.49 |
| Purity | >98% |
| Synonyms | E-2012,E2012 |
| SMILES | CC1=CN(C=N1)C2=C(C=C(C=C2)/C=C/3\CCCN(C3=O)[[email protected]@H](C)C4=CC=C(C=C4)F)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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