endo-BCN-PEG2-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bicyclo[6.1.0]nonyne (BCN) moiety, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing substrates. Its application in PROTAC development allows for targeted protein degradation, making it a valuable tool in chemical biology and drug discovery.
endo-BCN-PEG2-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bicyclo[6.1.0]nonyne (BCN) moiety, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing substrates. Its application in PROTAC development allows for targeted protein degradation, making it a valuable tool in chemical biology and drug discovery.
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