Catalog No.
Product Name
Application
Product Information
Citations
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Bifunctional Chelator
BCN-NODAGA is a bifunctional chelator that effectively binds to radionuclides, facilitating the formation of radionuclide conjugates (RDCs). This compound allows for targeted delivery to biomolecules, making it a valuable tool for medical imaging applications and therapeutic strategies. Its ability to form stable complexes enhances its utility in radiopharmaceutical development for diagnostics and treatment in oncology and other diseases. -
Bifunctional Chelator
BCN-DOTA is a bifunctional chelator that features a cyclooctyne linkage, allowing for the efficient radiolabeling with zirconium-89. This compound serves as a versatile radionuclide-labeled drug conjugate (RDC) designed for targeting specific biomolecules, cells, or tissues in vivo. BCN-DOTA is applicable in various research fields, including theranostics, molecular imaging, and targeted radiotherapy, enabling precise delivery and tracking of therapeutic agents. -
Bifunctional Chelator
BCN-DOTA-GA is a bifunctional chelator characterized by a cyclooctyne linkage and DOTA moiety. This reagent allows for efficient labeling with radioactive zirconium-89, enabling its use as a radionuclide-labeled drug conjugate (RDC). BCN-DOTA-GA is suitable for targeted applications in molecular imaging and radiotherapy, facilitating precise interactions with specific biomolecules, cells, or tissues in various research settings. -
ADC Linker
BCN-linker-DXd 2 is a specialized ADC (antibody-drug conjugate) linker designed for targeted delivery of cytotoxic agents to cancer cells. This compound facilitates the conjugation of drugs to antibodies, enhancing specificity and reducing off-target effects in cancer therapy. It is applicable in research focused on ADC development and optimization for improved therapeutic efficacy against various types of tumors. -
Drug-Linker Conjugates for ADC
endo-BCN-PEG4-Val-Cit-PAB-MMAE is a cleavable linker specifically designed for antibody-drug conjugates (ADCs), facilitating the targeted delivery of therapeutic agents. This compound features a 4-unit polyethylene glycol (PEG) chain and incorporates a BCN group that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its versatility is highly applicable in the development of ADCs, enhancing the efficacy and specificity of cancer therapies. -
Drug-Linker Conjugate for ADC
BCN-HS-PEG2(vcPABC-MMAE)2 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. This compound incorporates a cleavable linker and the microtubule inhibitor MMAE, facilitating targeted delivery of cytotoxic agents to cancer cells. BCN-HS-PEG2(vcPABC-MMAE)2 is vital for researchers involved in the development and synthesis of ADCs, enhancing therapeutic efficacy while minimizing systemic toxicity. -
Fluorescent Dye
Coumarin-PEG2-endoBCN is a fluorescent dye that incorporates a coumarin fluorophore, functioning as a versatile click chemistry reagent. It exhibits strong fluorescence properties, making it suitable for various biological imaging applications. This compound can be utilized in the labeling of biomolecules, facilitating studies in cellular dynamics and molecular interactions. -
Fluorochrome Dye
Cy5-PEG3-endo-BCN is a fluorochrome dye that features the Cyanine 5 (Cy5) structure with three polyethylene glycol (PEG) units. This compound includes the hydrophilic bidentate macrocyclic ligand endo-BCN, enabling the synthesis of macrocyclic complexes. In the context of click chemistry, endo-BCN readily reacts with azide-containing molecules to form stable triazole linkages without the need for catalytic conditions, making it a valuable tool for bioconjugation and labeling applications in chemical biology and biomedical research. -
Fluorochrome Dye
Coumarin-C2-exo-BCN is a fluorochrome dye derivative of coumarin that features the lipophilic bidentate macrocyclic ligand exo-BCN. This compound enables the formation of macrocyclic complexes and plays a significant role in click chemistry, where it reacts with azide-containing molecules to produce stable triazoles without the need for catalysts. Coumarin-C2-exo-BCN is valuable in biological imaging and tracking applications, facilitating the study of molecular interactions and dynamics in various research contexts. -
Fluorochrome Dye
Cy3-PEG2-endo-BCN is a fluorochrome dye derived from Cyanine 3 (Cy3) that incorporates two polyethylene glycol (PEG) units and the bidentate macrocyclic ligand endo-BCN. This structure enables its use in click chemistry, allowing it to react efficiently with azide-containing molecules to form stable triazole linkages without the need for catalysts. Cy3-PEG2-endo-BCN is ideal for various biological applications, including fluorescence labeling and imaging, facilitating the study of cellular processes and molecular interactions. -
ADC Linker
BCN-exo-PEG3-maleimide is an ADC linker featuring three PEG units and a bidentate macrocyclic ligand, BCN. It facilitates the formation of stable triazole structures through click chemistry with azide-containing molecules, eliminating the need for catalysts. The maleimide moiety is designed to degrade in aqueous conditions, making it suitable for various drug delivery applications and enhancing the efficacy of antibody-drug conjugates (ADCs) in targeted therapy research. -
ADC Linker
bis-PEG2-endo-BCN is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This compound features a cyclooctyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling precise conjugation. Its implementation in ADC development enhances targeted delivery of therapeutics, making it valuable for research applications in oncology and drug development. -
ADC Linker
Aminooxy-PEG2-BCN is a cleavable linker designed for use in antibody-drug conjugate (ADC) synthesis. This reagent features a BCN (cyclooctyne) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique structure enables efficient conjugation in the development of targeted therapeutics, enhancing both delivery and efficacy of payloads in cancer research and other biomedical applications. -
ADC Linker
Mal-PEG2-bis-PEG3-BCN is a cleavable linker designed for use in antibody-drug conjugates (ADCs). Featuring a BCN moiety, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enhancing conjugation efficiency. This reagent is ideal for the development of targeted therapies in cancer research and other applications requiring precise drug delivery mechanisms. -
ADC Linker
GDP-L-Fuc-PEG4-BCN is a cleavable linker designed for use in antibody-drug conjugates (ADCs). This linker facilitates the efficient conjugation of antibodies with cytotoxic drugs, enhancing targeted delivery to tumor cells. Its incorporation allows for controlled release of therapeutic agents upon internalization, making it suitable for cancer research and the development of innovative ADC therapeutics. -
PROTAC linker
Boc-gly-PEG3-endo-BCN is a cleavable PEG-based linker designed for targeted protein degradation applications through PROTAC technology. Its biocompatible structure facilitates the synthesis of antibody-drug conjugates (ADCs) by serving as a versatile linker. The presence of a bicyclo[6.1.0]nonyne (BCN) group allows for efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-containing molecules, making it a valuable reagent for click chemistry in biological research. -
ADC Linker
BCN-PEG4-HyNic is a cleavable linker designed for antibody-drug conjugate (ADC) synthesis, featuring a four-unit polyethylene glycol (PEG) spacer. Its primary mechanism involves click chemistry, specifically through the strain-promoted alkyne-azide cycloaddition (SPAAC) reaction, which facilitates the conjugation of azide-containing biomolecules. This reagent is ideal for researchers developing targeted therapeutics, enabling enhanced delivery and reduced systemic toxicity of cytotoxic drugs in cancer therapy. -
ADC Linker
BCN-exo-PEG2-maleimide is an ADC linker characterized by the presence of two PEG units and a bidentate macrocyclic ligand, BCN. This compound facilitates the formation of stable triazole linkages through click chemistry by reacting with azide-containing molecules, and operates without the need for catalysts. Its maleimide group is hydrolytically labile in aqueous environments, making it suitable for applications in drug delivery and bioconjugation studies. -
Linker Intermediate
BCN-HS-PEG2-bis(PNP) is a p-nitrophenyl-containing linker intermediate designed for use in antibody-drug conjugate (ADC) applications. It facilitates the conjugation of cytotoxins with peptide linkers, thereby enabling the formation of stable Drug-Linker Conjugates. BCN-HS-PEG2-bis(PNP) has demonstrated efficacy in coupling with vc-PABC-MMAE, making it a valuable reagent in ADC development for targeted cancer therapies. -
ADC Linker
Endo-BCN-Fmoc-L-Lysine is a specialized linker featuring the bidentate macrocyclic ligand endo-BCN, designed for use in antibody-drug conjugate (ADC) applications. This compound facilitates the synthesis of macrocyclic complexes and participates in click chemistry, where it can react with azide-containing molecules to form stable triazoles without the need for catalysts. Its properties make it particularly valuable in bioconjugation and therapeutic development research. -
ADC Linker
BCN-exo-PEG2-NH2 is an ADC linker featuring two polyethylene glycol (PEG) units. This compound incorporates the hydrophilic bidentate macrocyclic ligand, BCN, facilitating the formation of macrocyclic complexes. In click chemistry applications, BCN efficiently reacts with azide-containing molecules, yielding stable triazoles without the need for catalysts, making it valuable for antibody-drug conjugate (ADC) development and other bioconjugation strategies. -
ADC Linker
BCN-endo-PEG7-NH2 is a bifunctional ADC linker featuring a 7-unit PEG spacer and the lipophilic macrocyclic ligand endo-BCN. This compound enables efficient conjugation through click chemistry, allowing stable triazole formation with azide-containing molecules without the need for catalysts. BCN-endo-PEG7-NH2 is suitable for applications in antibody-drug conjugate (ADC) development and other bioconjugation techniques, facilitating targeted delivery and enhancing therapeutic efficacy in chemical biology research. -
ADC Linker
BCN-PEG3-Biotin is a non-cleavable three-unit polyethylene glycol (PEG) linker specifically designed for use in antibody-drug conjugates (ADCs). This reagent features a bicyclo[6.1.0]nonyne (BCN) group that facilitates strain-promoted azide-alkyne cycloaddition (SPAAC) with azide-containing molecules. It serves as a valuable tool in the synthesis of ADCs, enhancing stability while providing biotin functionality for further bioconjugation applications in research and development. -
ADC Linker
BCN-endo-PEG2-maleimide is a bifunctional ADC linker featuring two polyethylene glycol (PEG) units and a maleimide group. It acts as a bioconjugation reagent, facilitating stable linkages to azide-containing molecules through a copper-free click chemistry reaction, yielding stable triazoles. The maleimide moiety allows for selective conjugation to thiol groups, making it suitable for drug delivery applications. This compound is primarily utilized in the development of antibody-drug conjugates (ADCs) and other bioconjugation strategies. -
ADC Linker
endo-BCN-PEG4-acid is a versatile cleavable linker designed for antibody-drug conjugates (ADCs), facilitating targeted drug delivery. Featuring a bicyclo[6.1.0]nonyne (BCN) moiety, this compound enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is particularly useful in bioconjugation and drug development applications, allowing for the precise attachment of therapeutic agents to antibodies. -
PROTAC Linkers
BCN-PEG4-NHS ester is a PEG-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). Its primary mechanism involves the BCN group, which facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This reagent is essential for enabling targeted protein degradation and enhancing the therapeutic potential of PROTACs in chemical biology research. Additionally, it serves as an effective tool for bioconjugation applications, expanding the versatility of synthetic approaches in drug discovery. -
ADC Linker
BCN-exo-PEG7-maleimide is an ADC linker featuring a polyethylene glycol (PEG) spacer of seven units, facilitating improved solubility and stability. This compound incorporates the bidentate macrocyclic ligand BCN, enabling efficient synthesis of macrocyclic complexes. In click chemistry applications, BCN selectively reacts with azide-containing molecules to yield stable triazoles without the need for catalysts. Additionally, the maleimide functional group undergoes hydrolytic degradation, making it suitable for drug delivery research. -
ADC Linker
BCN-PEG3-OH is a non-cleavable linker specifically designed for antibody-drug conjugate (ADC) synthesis. As a click chemistry reagent, it features a bicyclo[6.1.0]nonyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound supports robust conjugation strategies, enhancing the delivery of cytotoxic agents in targeted cancer therapies. Its efficiency makes it an invaluable tool in the development of ADCs for various research applications. -
ADC Linker
BCN-SS-NHS is a cleavable linker designed for the synthesis of antibody-drug conjugates (ADCs). This reagent features a BCN group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, enabling efficient conjugation. Its unique properties enhance the targeting and delivery of therapeutic agents, making it a valuable tool in the development of ADCs for various cancer research applications. -
PROTAC Linker
endo-BCN-PEG2-C2-NHS ester functions as a PEG-based PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This linker is designed to enhance target specificity and efficacy in targeted protein degradation research. Its properties make it suitable for studies focusing on cellular signaling, protein homeostasis, and therapeutic interventions in various diseases. -
PROTAC Linker
endo-BCN-PEG4-NHS ester is a PEG-based PROTAC linker specifically designed for the synthesis of PROTACs. This compound features a BCN group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It plays a crucial role in the development of targeted protein degradation strategies and is suitable for applications in drug discovery and chemical biology research. -
PROTAC Linker
endo-BCN-PEG4-PFP ester is a PEG-based PROTAC linker designed for the synthesis of targeted protein degraders. Featuring a bicyclo[6.1.0]nonyne (BCN) group, this compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its robust click chemistry properties make it suitable for applications in protein degradation research and therapeutic development. -
PROTAC Linker
exo BCN-O-PNB is a versatile alkyl/ether-based PROTAC linker designed for the synthesis of PROTAC molecules. As a click chemistry reagent, it features a BCN group that enables strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This mechanism facilitates the creation of stable and efficient bifunctional molecules, aiding in targeted protein degradation research applications. -
PROTAC Linker
endo-BCN-PEG2-alcohol is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclo[6.1.0]nonyne (BCN) moiety, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its application in PROTAC development facilitates targeted protein degradation and offers significant potential for therapeutic research in various diseases. -
PROTAC Linkers
5-endo-BCN-pentanoic acid is a versatile PROTAC linker featuring a BCN group, which enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This alkyl chain-based linker facilitates the synthesis of PROTACs, enhancing targeted protein degradation and enabling innovative therapeutic strategies. Its applications span various biological research areas, allowing for precise manipulation of protein interactions to study cellular processes. -
Ligands for Target Protein for PROTAC
BCN-sulfonamide-PEG2-sulfonamide-N-bis(ethanol) serves as a versatile ligand for target proteins in PROTAC applications. This compound incorporates a sulfonamide linker designed to enhance the solubility of linker-conjugates. It is particularly useful in the synthesis of PROTACs aimed at inducing targeted degradation of proteins with potential antitumor activity. -
PROTAC linker
endo-BCN-PEG3-mal is a PEG-based PROTAC linker designed for efficient synthesis of PROTACs. This compound features a BCN moiety that engages in strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating targeted protein degradation studies. Its versatile application in chemical biology makes it valuable for research involving protein modulation and therapeutic development. -
PROTAC Linker
endo-BCN-O-PNB is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclononyne (BCN) moiety that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. It is a valuable tool for researchers focusing on targeted protein degradation and the development of novel therapeutic strategies in chemical biology. -
PROTAC Linker
endo-BCN-PEG2-NH2 is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. It features a bicyclo[6.1.0]nonyne (BCN) group, enabling efficient strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with azide-bearing compounds. This linker is pivotal for advancing research in targeted protein degradation and optimizing the pharmacological profiles of novel therapeutic agents. Its utility in PROTAC development makes it an essential tool for scientists exploring innovative approaches in drug discovery and cellular regulation. -
PROTAC Linker
endo-BCN-PEG8-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs through its unique structure. As a click chemistry reagent, it features a BCN moiety capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound is essential for advancing targeted protein degradation research and enhancing the efficiency of PROTAC assembly in various biological applications. -
Click Chemical
exo-BCN-L-Lysine is a click chemistry reagent that acts as a versatile linker for the synthesis of PROTAC molecules. Featuring a bicyclo[6.1.0]nonyne (BCN) functional group, it enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing compounds. This property makes exo-BCN-L-Lysine particularly valuable in the development of targeted protein degraders and other bioconjugation applications in chemical biology research. -
PROTAC Linker
BCN-exo-PEG3-NH2 is a PEG-based linker designed for PROTAC (PROteolysis-TArgeting Chimeras) synthesis. This compound features a BCN (bicyclononyne) group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique properties make it suitable for applications in targeted protein degradation research, enabling precise modulation of protein levels within biological systems. -
Ligands for E3 Ligase
(S,R,S)-AHPC-C2-PEG3-BCN is a ligand targeting E3 ligases, specifically the von Hippel-Lindau (VHL) E3 ligase. It plays a vital role in the synthesis of PROTACs (proteolysis-targeting chimeras), which mediate targeted degradation of proteins within cells. This compound is intended for research applications in protein degradation and cellular regulation studies. -
PROTAC linker
endo-BCN-PEG3-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs by enabling targeted protein degradation. This compound features a bicyclononyne (BCN) group, which allows for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its applications extend to the development of advanced therapeutic modalities in chemical biology and drug discovery. -
PROTAC Linker
endo-BCN-PEG3-acid is a PEG-based PROTAC linker that facilitates the construction of proteolysis-targeting chimeras (PROTACs). This compound plays a critical role in enhancing target degradation by connecting ligands to E3 ligases. Its utility in protein modulation research positions it as a valuable tool for studies focusing on targeted protein degradation strategies in various diseases. -
PROTAC Linker
endo-BCN-PEG3-NH2 is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. Featuring a BCN group, this compound enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, facilitating the formation of complex bioconjugates. Its application in chemical biology makes it a valuable tool for researchers investigating targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linker
endo-BCN-PEG2-acid is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features a bicyclononyne (BCN) group, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique chemoselectivity enhances the development of targeted protein degradation applications in various biological research contexts. -
PROTAC Linker
BCN-PEG4-acid is a PEG-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). Featuring a bicyclononyne (BCN) moiety, this compound is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its use facilitates the development of targeted protein degradation strategies, enhancing the versatility and effectiveness of drug discovery research. -
PROTAC Linker
endo-BCN-PEG2-PFP ester serves as a PEG-based linker in the synthesis of PROTACs, functioning primarily through its BCN group. This compound facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules, thereby enabling precise protein degradation applications. Its utility extends to various research areas, including targeted protein modulation and therapeutic development strategies. -
PROTAC linker
endo-BCN-PEG8-acid serves as a PEG-based linker for PROTAC (Proteolysis Targeting Chimera) synthesis, enabling targeted protein degradation. This compound features a BCN moiety, allowing for strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its high efficiency and versatility make it an essential reagent for research in targeted therapeutic strategies and cellular signaling studies.
