Ethacrynic acid D5 is a deuterium-labeled analog of Ethacrynic acid, primarily targeting glutathione S-transferases (GSTs). This compound exhibits diuretic properties and serves as a potent inhibitor of the NF-kB signaling pathway, with implications in modulating leukotriene formation. Additionally, it inhibits L-type voltage-dependent and store-operated calcium channels, contributing to the relaxation of airway smooth muscle cells. Ethacrynic acid D5 also demonstrates anti-inflammatory effects, evidenced by its ability to reduce retinoid-induced ear edema in murine models, making it valuable in related research applications.
Ethacrynic acid D5 is a deuterium-labeled analog of Ethacrynic acid, primarily targeting glutathione S-transferases (GSTs). This compound exhibits diuretic properties and serves as a potent inhibitor of the NF-kB signaling pathway, with implications in modulating leukotriene formation. Additionally, it inhibits L-type voltage-dependent and store-operated calcium channels, contributing to the relaxation of airway smooth muscle cells. Ethacrynic acid D5 also demonstrates anti-inflammatory effects, evidenced by its ability to reduce retinoid-induced ear edema in murine models, making it valuable in related research applications.
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