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- Kumar M,et al. Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NF百B, Behav Brain Res, 2018, Oct 1;351:4-16 29807069
- Wei J,et al. Inhibition of RHO Kinase by Fasudil Attenuates Ischemic Lung Injury After Cardiac Arrest in Rats, Shock, 2018, Dec;50(6):706-713 29283979
- Hofni A,et al. Fasudil ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats: a possible role of Rho kinase, Naunyn Schmiedebergs Arch Pharmacol, 2017, Aug;390(8):801-811 28493050
|Storage||at -20°C 3 years Powder|
|Chemical Name||1-(5-Isoquinolinesulfonyl)homopiperazine hydrochloride|
|Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).|
|Solubility (25°C) *||In vitro||DMSO||5 mg/mL (15.25 mM)|
|Water||65 mg/mL (198.27 mM)|
|Ethanol||<1 mg/mL (<1 mM)|
|In vivo||Saline||30 mg/mL|
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||30.51 mL||152.53 mL||305.06mL|
|0.5 mM||6.1 mL||30.51 mL||61.01 mL|
|1 mM||3.05 mL||15.25 mL||30.51 mL|
|5 mM||0.61 mL||3.05 mL||6.1 mL|
*The above data is based on the productmolecular weight 327.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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