Fasudil HCl (HA-1077)

Catalog No.: A10381

ROCK inhibitor

Fasudil HCl (HA-1077)

Fasudil HCl (HA-1077) Chemical Structure

CAS NO. 105628-07-7

Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).

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250 mg
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500 mg
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Kumar M, .et al. Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NF??B, Behav Brain Res, 2018, Oct 1;351:4-16 PMID: 29807069
  • Wei J, .et al. Inhibition of RHO Kinase by Fasudil Attenuates Ischemic Lung Injury After Cardiac Arrest in Rats, Shock, 2018, Dec;50(6):706-713 PMID: 29283979
  • Hofni A, .et al. Fasudil ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats: a possible role of Rho kinase, Naunyn Schmiedebergs Arch Pharmacol, 2017, Aug;390(8):801-811 PMID: 28493050

Biological Activity

Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
Targets
ROCK2 (Cell-free assay) PKA (Cell-free assay) PKG (Cell-free assay) PKC (Cell-free assay) MLCK (Cell-free assay)
330 nM(Ki)1.6 μM(Ki)1.6 μM(Ki)3.3 μM(Ki)36 μM(Ki)
In vitro (25°C) DMSO 5 mg/mL (15.25 mM)
Water 65 mg/mL (198.27 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.51 mL 152.53 mL 305.06 mL
0.5 mM 6.1 mL 30.51 mL 61.01 mL
1 mM 3.05 mL 15.25 mL 30.51 mL
5 mM 0.61 mL 3.05 mL 6.1 mL

*The above data is based on the productmolecular weight 327.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10381
Actions Inhibitor
M. Wt 327.8
Formula C14H17N3O2S.HCl
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 105628-07-7
Synonyms AT-877
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3.Cl

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