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Fasudil HCl (HA-1077)

Catalog No.: A10381

ROCK inhibitor

Fasudil HCl (HA-1077)

Fasudil HCl (HA-1077) Chemical Structure

CAS NO. 105628-07-7

Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Chengyu Xiang, .et al. Fasudil Ameliorates Osteoporosis Following Myocardial Infarction by Regulating Cardiac Calcitonin Secretion, J Cardiovasc Transl Res, 2022, May 12 PMID: 35551627
  • Yeonmi Lee, .et al. Haploidy in somatic cells is induced by mature oocytes in mice, Commun Biol, 2022, Jan 25;5(1):95 PMID: 35079104
  • Jiwan Choi, .et al. Efficient hepatic differentiation and regeneration potential under xeno-free conditions using mass-producible amnion-derived mesenchymal stem cells, Stem Cell Res Ther, 2021, Nov 12;12(1):569
  • Jee Myung Yang, .et al. Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats, Exp Mol Med, 2021, Apr;53(4):631-642 PMID: 33828232
  • Jooyoung Lee, .et al. Hepatogenic Potential and Liver Regeneration Effect of Human Liver-derived Mesenchymal-Like Stem Cells, Cells, 2020, Jun; 9(6): 1521 PMID: 32580448
  • Kumar M, .et al. Fasudil hydrochloride ameliorates memory deficits in rat model of streptozotocin-induced Alzheimer's disease: Involvement of PI3-kinase, eNOS and NFκB, Behav Brain Res, 2018, Oct 1;351:4-16 PMID: 29807069
  • Wei J, .et al. Inhibition of RHO Kinase by Fasudil Attenuates Ischemic Lung Injury After Cardiac Arrest in Rats, Shock, 2018, Dec;50(6):706-713 PMID: 29283979
  • Hofni A, .et al. Fasudil ameliorates endothelial dysfunction in streptozotocin-induced diabetic rats: a possible role of Rho kinase, Naunyn Schmiedebergs Arch Pharmacol, 2017, Aug;390(8):801-811 PMID: 28493050

Biological Activity

Fasudil HCl is a cyclic nucleotide-dependent protein kinase inhibitor and Rho-associated kinase inhibitor (IC50 = 10.7 μM).
ROCK2 (Cell-free assay) PKA (Cell-free assay) PKG (Cell-free assay) PKC (Cell-free assay) MLCK (Cell-free assay)
330 nM(Ki)1.6 μM(Ki)1.6 μM(Ki)3.3 μM(Ki)36 μM(Ki)
In vitro (25°C) DMSO 5 mg/mL (15.25 mM)
Water 60 mg/mL (183.02 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30.51 mL 152.53 mL 305.06 mL
0.5 mM 6.1 mL 30.51 mL 61.01 mL
1 mM 3.05 mL 15.25 mL 30.51 mL
5 mM 0.61 mL 3.05 mL 6.1 mL

*The above data is based on the productmolecular weight 327.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10381
Actions Inhibitor
CAS No. 105628-07-7
Formula C14H17N3O2S.HCl
M. Wt 327.8
Purity >98%
Synonyms AT-877

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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