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Fig. 1 · Structure
Cat. No.
A21628
CAS No.
103745-39-7
Formula
C14H17N3O2S
Mol. Weight
291.37

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Fasudil

Cat. No. A21628 CAS 103745-39-7

ROCK inhibitor

Fasudil (HA-1077; AT877), is a nonspecific ROCK inhibitor and also has inhibitory effect on protein kinases.

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Biological Activity

Target & Activity

Target Activity Value
p160ROCK Ki 0.33 μM
ROCK2 IC50 0.158 μM
PKA IC50 4.58 μM
PKC IC50 12.30 μM
PKG IC50 1.65 μM

Cellular Effect

Cell Line Activity Value Description Reference
HASMC IC50 1.3 μM Antiproliferative activity against human HASMC cells assessed as inhibition of cell proliferation measured after 24 hrs by MTT assay [PMID: 33569941]
Sf9 IC50 300 nM Inhibition of human recombinant N-terminal his-tagged ROCK1 (3-543) expressed in baculovirus infected Sf9 cells using Biotin-Ahx-AKRRLSSLRA-CONH2 substrate and [gamma-33P]ATP after 90 mins by scintillation proximity assay [PMID: 17018693]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 103745-39-7
Applications ROCK inhibitor
Formula C14H17N3O2S
Molecular Weight 291.37
Synonyms HA-1077; AT877
SMILES
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCCC3)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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