Filipin complex is a potent polyene macrolide antifungal antibiotic that primarily targets membrane cholesterol. By inserting into cellular membranes, it sequesters cholesterol, thereby inhibiting the entry of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The complex comprises approximately 75.8% Filipin III, 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I, making it a valuable tool in antifungal research and viral entry studies. Its characteristic fluorescence spectrum (Ex/Em = 380/430 nm) further enhances its utility in biological applications.
Filipin complex is a potent polyene macrolide antifungal antibiotic that primarily targets membrane cholesterol. By inserting into cellular membranes, it sequesters cholesterol, thereby inhibiting the entry of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV). The complex comprises approximately 75.8% Filipin III, 10.8% Filipin IV, 9.1% Filipin II, and 1.2% Filipin I, making it a valuable tool in antifungal research and viral entry studies. Its characteristic fluorescence spectrum (Ex/Em = 380/430 nm) further enhances its utility in biological applications.
Product Information
Catalog Num
A33159
Formula
C105H174O30
Molecular Weight
1916.517
CAS Number
11078-21-0
SMILES
CCCCC[C@@H]([R1])[C@]1([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@H](O)/C(C)=C/C=C/C=C/C=C/C=C/[C@H]([R2])[C@@H](C)OC1=O.[Filipin I :R1=H,R2=H 1% Filipin II :R1=H,R2=OH 9% Filipin III :R1=(R)-OH,R2=OH 76% Filipin IV :R1=(S)-OH,R2=OH 11%]
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