FK-506 (Tacrolimus)

Catalog No.: A10389

mTOR inhibitor

FK-506 (Tacrolimus)

FK-506 (Tacrolimus) Chemical Structure

CAS NO. 104987-11-3

FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.

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50 mg

Regular Price: $55.00

Special Price $44.00

100 mg

Regular Price: $100.00

Special Price $80.00

500 mg

Regular Price: $250.00

Special Price $200.00

10mM * 1mL in DMSO

Regular Price: $68.00

Special Price $54.40

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  • Ogawa Y, .et al. Inhibition of astrocytic adenosine receptor A2A attenuates microglial activation in a mouse model of Sandhoff disease, Neurobiol Dis, 2018, Oct;118:142-154 PMID: 30026035
  • Yuko Okamoto, .et al. In vivo drug delivery efficiency of albumin-encapsulated liposomes as hydrophobic drug carriers, J Drug Deliv Sci Technol, 2018, 47: 62-66

Biological Activity

FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.
Targets
FKBP12 (T cells)
In vitro (25°C) DMSO 81 mg/mL (100.74 mM)
Water Insoluble
Ethanol 71 mg/mL (88.31 mM)
In vivo 5% DMSO+corn oil 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.44 mL 62.19 mL 124.38 mL
0.5 mM 2.49 mL 12.44 mL 24.88 mL
1 mM 1.24 mL 6.22 mL 12.44 mL
5 mM 0.25 mL 1.24 mL 2.49 mL

*The above data is based on the productmolecular weight 804. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10389
Actions Inhibitor
CAS No. 104987-11-3
Formula C44H69NO12
M. Wt 804
Purity >98%
Synonyms FK506, Fujimycin, Prograf , Tacrolimus
SMILES C[[email protected]@H]1C[[email protected]@H]([[email protected]@H]2[[email protected]](C[[email protected]]([[email protected]@](O2)(C(=O)C(=O)N3CCCC[[email protected]]3C(=O)O[[email protected]@H]([[email protected]@H]([[email protected]](CC(=O)[[email protected]@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)O)/C)O)C)OC)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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