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FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.
Targets
| FKBP12 (T cells) | ||||
| In vitro | DMSO | 94 mg/mL (116.91 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 83 mg/mL (103.23 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 12.44 mL | 62.19 mL | 124.38 mL |
| 0.5 mM | 2.49 mL | 12.44 mL | 24.88 mL |
| 1 mM | 1.24 mL | 6.22 mL | 12.44 mL |
| 5 mM | 0.25 mL | 1.24 mL | 2.49 mL |
*The above data is based on the productmolecular weight 804. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Technical Details
| Catalog Num | A10389 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 804 |
| Formula | C44H69NO12 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 104987-11-3 |
| Synonyms | FK506, Fujimycin, Prograf , Tacrolimus |
| SMILES | C[[email protected]@H]1C[[email protected]@H]([[email protected]@H]2[[email protected]](C[[email protected]]([[email protected]@](O2)(C(=O)C(=O)N3CCCC[[email protected]]3C(=O)O[[email protected]@H]([[email protected]@H]([[email protected]](CC(=O)[[email protected]@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)O)/C)O)C)OC)OC |
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