FK-506 (Tacrolimus)

Catalog No.: A10389

mTOR inhibitor

FK-506 (Tacrolimus) Chemical Structure

CAS NO. 104987-11-3

FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.

Availability: In stock

Package Price Qty
50 mg
$55.00
100 mg
$100.00
500 mg
$250.00
10mM * 1mL in DMSO
$68.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.
Targets
FKBP12 (T cells)
In vitro DMSO 94 mg/mL (116.91 mM)
Water <1 mg/mL (<1 mM)
Ethanol 83 mg/mL (103.23 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 12.44 mL 62.19 mL 124.38 mL
0.5 mM 2.49 mL 12.44 mL 24.88 mL
1 mM 1.24 mL 6.22 mL 12.44 mL
5 mM 0.25 mL 1.24 mL 2.49 mL

*The above data is based on the productmolecular weight 804. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10389
Actions Inhibitor
M. Wt 804
Formula C44H69NO12
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 104987-11-3
Synonyms FK506, Fujimycin, Prograf , Tacrolimus
SMILES C[[email protected]@H]1C[[email protected]@H]([[email protected]@H]2[[email protected]](C[[email protected]]([[email protected]@](O2)(C(=O)C(=O)N3CCCC[[email protected]]3C(=O)O[[email protected]@H]([[email protected]@H]([[email protected]](CC(=O)[[email protected]@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[[email protected]@H]4CC[[email protected]]([[email protected]@H](C4)OC)O)/C)O)C)OC)OC

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