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$0.00 - Tan YJ, .et al. Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer, Future Med Chem, 2018, Sep 1;10(17):2039-2057 PMID: 30066578
Biological Activity
FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
Targets
| Notch | ||||
| 2.3 μM(EC50) |
| In vitro | DMSO | 80 mg/mL (182.43 mM) | |
| Water | Insoluble | ||
| Ethanol | 7 mg/mL (15.96 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.8 mL | 114.02 mL | 228.04 mL |
| 0.5 mM | 4.56 mL | 22.8 mL | 45.61 mL |
| 1 mM | 2.28 mL | 11.4 mL | 22.8 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
*The above data is based on the productmolecular weight 438.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13815 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 313967-18-9 |
| Formula | C25H30N2O5 |
| M. Wt | 438.52 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | FLI06,FLI 06 |
| SMILES | CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC4CCCCC4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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