FLI-06

Catalog No.: A13815

Gamma-secretase inhibitor

FLI-06

FLI-06 Chemical Structure

CAS NO. 313967-18-9

FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.

Availability: In stock

Package Price Qty
10 mg
$120.00
25 mg
$225.00
50 mg
$400.00
100 mg
$700.00
10mM * 1mL in DMSO
$130.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Tan YJ, .et al. Anticancer activities of a benzimidazole compound through sirtuin inhibition in colorectal cancer, Future Med Chem, 2018, Sep 1;10(17):2039-2057 PMID: 30066578

Biological Activity

FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
Targets
Notch
2.3 μM(EC50)
In vitro DMSO 80 mg/mL (182.43 mM)
Water Insoluble
Ethanol 7 mg/mL (15.96 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.8 mL 114.02 mL 228.04 mL
0.5 mM 4.56 mL 22.8 mL 45.61 mL
1 mM 2.28 mL 11.4 mL 22.8 mL
5 mM 0.46 mL 2.28 mL 4.56 mL

*The above data is based on the productmolecular weight 438.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13815
Actions Inhibitor
CAS No. 313967-18-9
Formula C25H30N2O5
M. Wt 438.52
Solubility DMSO
Purity >98%
Synonyms FLI06,FLI 06
SMILES CC1=C(C(C2=C(N1)CC(CC2=O)(C)C)C3=CC=C(C=C3)[N+](=O)[O-])C(=O)OC4CCCCC4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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