G194-0712 is a selective activator of histone deacetylase 5 (HDAC5), exhibiting an EC50 of 7.96 μM and a Kd of 2.53 μM. This compound promotes ACTN4-K417 deacetylation and enhances nuclear import while upregulating CSTA expression. G194-0712 has demonstrated efficacy in accelerating wound closure in chronic wound models, particularly in reducing wound area and epithelial gaps. Its applications extend to the study of chronic skin wounds, including diabetic, ischemic, and radiation injury-related wounds.
G194-0712 is a selective activator of histone deacetylase 5 (HDAC5), exhibiting an EC50 of 7.96 μM and a Kd of 2.53 μM. This compound promotes ACTN4-K417 deacetylation and enhances nuclear import while upregulating CSTA expression. G194-0712 has demonstrated efficacy in accelerating wound closure in chronic wound models, particularly in reducing wound area and epithelial gaps. Its applications extend to the study of chronic skin wounds, including diabetic, ischemic, and radiation injury-related wounds.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
