GDC-0068 (Ipatasertib, RG-7440)

Catalog No.: A11246

Akt Inhibitor

GDC-0068 (Ipatasertib, RG-7440)

GDC-0068 (Ipatasertib, RG-7440) Chemical Structure

CAS NO. 1001264-89-6

GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays

Availability: In stock

Package Price Qty
5 mg

Regular Price: $65.00

Special Price $52.00

10 mg

Regular Price: $90.00

Special Price $72.00

25 mg

Regular Price: $150.00

Special Price $120.00

10mM * 1mL in DMSO

Regular Price: $60.00

Special Price $48.00

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Biological Activity

GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays
Targets
Akt1 (Cell-free assay) Akt3 (Cell-free assay) Akt2 (Cell-free assay)
5 nM8 nM18 nM
In vitro DMSO 91 mg/mL (198.69 mM)
Water Insoluble
Ethanol 91 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.83 mL 109.17 mL 218.34 mL
0.5 mM 4.37 mL 21.83 mL 43.67 mL
1 mM 2.18 mL 10.92 mL 21.83 mL
5 mM 0.44 mL 2.18 mL 4.37 mL

*The above data is based on the productmolecular weight 458. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11246
Actions Inhibitor
CAS No. 1001264-89-6
Formula C24H32ClN5O2
M. Wt 458
Solubility DMSO
Purity >98%
Synonyms GDC0068, RG7440
SMILES C[[email protected]@H]1C[[email protected]](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[[email protected]](CNC(C)C)C4=CC=C(C=C4)Cl)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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