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GDC-0068 (Ipatasertib, RG-7440)

GDC-0068 (Ipatasertib, RG-7440)

Name: GDC-0068 (Ipatasertib, RG-7440)
SKU: A11246

Catalog No.: A11246

Akt Inhibitor

GDC-0068 (Ipatasertib, RG-7440) Chemical Structure

CAS NO. 1001264-89-6

GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays

Availability: In stock

Package	Price	Qty
5 mg	Regular Price: $80.00 Special Price $72.00
10 mg	Regular Price: $120.00 Special Price $108.00
25 mg	Regular Price: $240.00 Special Price $216.00
10mM * 1mL in DMSO	Regular Price: $95.00 Special Price $85.50

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Biological Activity

GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays

Targets

Akt1 (Cell-free assay)	Akt3 (Cell-free assay)	Akt2 (Cell-free assay)
5 nM	8 nM	18 nM

Solubility *

In vitro	DMSO	92 mg/mL (200.87 mM)
	Water	<1 mg/mL (<1 mM)
	Ethanol	92 mg/mL (200.87 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.83 mL	109.17 mL	218.34 mL
0.5 mM	4.37 mL	21.83 mL	43.67 mL
1 mM	2.18 mL	10.92 mL	21.83 mL
5 mM	0.44 mL	2.18 mL	4.37 mL

*The above data is based on the productmolecular weight 458. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Chemical Properties

Catalog Num	A11246
Actions	Inhibitor
M. Wt	458
Formula	C24H32ClN5O2
Solubility	DMSO
Purity	>98%
Storage	at -20°C 3 years Powder
CAS No.	1001264-89-6
Synonyms	GDC0068, RG7440
SMILES	C[[email protected]@H]1C[[email protected]](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[[email protected]](CNC(C)C)C4=CC=C(C=C4)Cl)O