GDC-0068 (Ipatasertib, RG-7440)

Catalog No.: A11246

Akt Inhibitor

GDC-0068 (Ipatasertib, RG-7440)

GDC-0068 (Ipatasertib, RG-7440) Chemical Structure

CAS NO. 1001264-89-6

GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays

Availability: In stock

Package Price Qty
5 mg

Regular Price: $80.00

Special Price $72.00

10 mg

Regular Price: $120.00

Special Price $108.00

25 mg

Regular Price: $240.00

Special Price $216.00

10mM * 1mL in DMSO

Regular Price: $95.00

Special Price $85.50

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays
Targets
Akt1 (Cell-free assay) Akt3 (Cell-free assay) Akt2 (Cell-free assay)
5 nM8 nM18 nM
In vitro DMSO 92 mg/mL (200.87 mM)
Water <1 mg/mL (<1 mM)
Ethanol 92 mg/mL (200.87 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.83 mL 109.17 mL 218.34 mL
0.5 mM 4.37 mL 21.83 mL 43.67 mL
1 mM 2.18 mL 10.92 mL 21.83 mL
5 mM 0.44 mL 2.18 mL 4.37 mL

*The above data is based on the productmolecular weight 458. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11246
Actions Inhibitor
M. Wt 458
Formula C24H32ClN5O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1001264-89-6
Synonyms GDC0068, RG7440
SMILES C[[email protected]@H]1C[[email protected]](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[[email protected]](CNC(C)C)C4=CC=C(C=C4)Cl)O

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