GDC-0068 (Ipatasertib, RG-7440)

Catalog No.: A11246
Akt Inhibitor
GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays
Grouped product items
Product Name Price Stock Qty
GDC-0068 5mg
$65.00
In stock
GDC-0068 10mg
$90.00
In stock
GDC-0068 25mg
$150.00
In stock
GDC-0068 10mM * 1mL in DMSO
$60.00
In stock

Important Notice: For research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Biological Activity
Discription GDC-0068 is a selective, ATP-competitive, pan-Akt inhibitor that targets Akt1, 2, and 3 with IC50 values of 5, 18, and 8 nM, respectively in cell-free assays
Targets
Target Value
Chemical Information
Catalog Num A11246
Formula C24H32ClN5O2
Molecular Weight 458
CAS Number 1001264-89-6
SMILES C[C@@H]1C[C@H](C2=C1C(=NC=N2)N3CCN(CC3)C(=O)[C@H](CNC(C)C)C4=CC=C(C=C4)Cl)O
Synonyms GDC0068, RG7440
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro DMSO 91 mg/mL (198.69 mM)
Water Insoluble
Ethanol 91 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.83 mL 109.17 mL 218.34 mL
0.5 mM 4.37 mL 21.83 mL 43.67 mL
1 mM 2.18 mL 10.92 mL 21.83 mL
5 mM 0.44 mL 2.18 mL 4.37 mL
Useful Calculator

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Please check COA/MSDS for correct molecular weight.

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