Ipatasertib dihydrochloride

Catalog No.: A21734

pan-Akt inhibitor

Ipatasertib dihydrochloride

Ipatasertib dihydrochloride Chemical Structure

CAS NO. 1396257-94-5

Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA.

Availability: In stock

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2 mg

Regular Price: $45.00

Special Price $36.00

5 mg

Regular Price: $90.00

Special Price $72.00

10 mg

Regular Price: $175.00

Special Price $140.00

50 mg

Regular Price: $515.00

Special Price $412.00

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Biological Activity

Ipatasertib dihydrochloride (GDC-0068 dihydrochloride) is a highly selective pan-Akt inhibitor targeting Akt1/2/3 with IC50 of 5/18/8 nM, 620-fold selectivity over PKA.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.84 mL 94.18 mL 188.35 mL
0.5 mM 3.77 mL 18.84 mL 37.67 mL
1 mM 1.88 mL 9.42 mL 18.84 mL
5 mM 0.38 mL 1.88 mL 3.77 mL

*The above data is based on the productmolecular weight 530.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21734
Actions Inhibitor
CAS No. 1396257-94-5
Formula C24H34Cl3N5O2
M. Wt 530.92
Purity >98%
Synonyms GDC-0068 (dihydrochloride), GDC0068, GDC0068; RG-7440 dihydrochloride, RG7440, RG 7440
SMILES ClC1=CC=C([[email protected]@H](CNC(C)C)C(N2CCN(C3=C([[email protected]](C)C[[email protected]]4O)C4=NC=N3)CC2)=O)C=C1.[H]Cl.[H]Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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