H8-A5 is a specific inhibitor of human histone deacetylase 8 (HDAC8) that employs a zinc-binding group (ZBG) within its pharmacophore design to enhance its selectivity. With IC50 values ranging from 1.8 to 1.9 μM, H8-A5 demonstrates potent antiproliferative activity in MDA-MB-231 breast cancer cells, making it a valuable tool for cancer research. Molecular docking and dynamics studies indicate strong binding affinity to HDAC8, suggesting its potential for therapeutic development in targeting HDAC-mediated pathways in oncology.
H8-A5 is a specific inhibitor of human histone deacetylase 8 (HDAC8) that employs a zinc-binding group (ZBG) within its pharmacophore design to enhance its selectivity. With IC50 values ranging from 1.8 to 1.9 μM, H8-A5 demonstrates potent antiproliferative activity in MDA-MB-231 breast cancer cells, making it a valuable tool for cancer research. Molecular docking and dynamics studies indicate strong binding affinity to HDAC8, suggesting its potential for therapeutic development in targeting HDAC-mediated pathways in oncology.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
