HDAC8-IN-12 is a selective inhibitor of histone deacetylase 8 (HDAC8) with an IC50 of 0.12 nM. This non-hydroxamic acid compound demonstrates significant anti-tumor activity, particularly in breast cancer models, by activating T cells and skewing the macrophage population towards M1 while reducing M2 macrophages. In an orthotopic mouse model of breast cancer, HDAC8-IN-12 at a dose of 50 mg/kg exhibits notable tumor suppressive effects, making it a valuable tool for research in cancer immunotherapy and epigenetic regulation.
HDAC8-IN-12 is a selective inhibitor of histone deacetylase 8 (HDAC8) with an IC50 of 0.12 nM. This non-hydroxamic acid compound demonstrates significant anti-tumor activity, particularly in breast cancer models, by activating T cells and skewing the macrophage population towards M1 while reducing M2 macrophages. In an orthotopic mouse model of breast cancer, HDAC8-IN-12 at a dose of 50 mg/kg exhibits notable tumor suppressive effects, making it a valuable tool for research in cancer immunotherapy and epigenetic regulation.
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