Imatinib Mesylate

Catalog No.: A10468

Bcr-Abl inhibitor

Imatinib Mesylate

Imatinib Mesylate Chemical Structure

CAS NO. 220127-57-1

Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.

Availability: In stock

Package Price Qty
100 mg
$60.00
200 mg
$70.00
500 mg
$80.00
10mM * 1mL in DMSO
$50.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Genevra Kuziel, .et al. Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells, Cancers (Basel), 2020, Jul 28;12(8):E2083 PMID: 32731354

Biological Activity

Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.
Targets
PDGFR (Cell-free assay) c-Kit (M-07e cells) v-Abl (Cell-free assay)
100 nM100 nM600 nM
In vitro DMSO 101 mg/mL (171.26 mM)
Water 101 mg/mL (171.26 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.96 mL 84.79 mL 169.58 mL
0.5 mM 3.39 mL 16.96 mL 33.92 mL
1 mM 1.7 mL 8.48 mL 16.96 mL
5 mM 0.34 mL 1.7 mL 3.39 mL

*The above data is based on the productmolecular weight 589.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10468
Actions Inhibitor
CAS No. 220127-57-1
Formula C29H31N7O.CH4SO3
M. Wt 589.7
Purity >98%
Synonyms Gleevec, Glivec, CGP-57148B, STI-571
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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