Imatinib Mesylate

Catalog No.: A10468

Bcr-Abl inhibitor

Imatinib Mesylate

Imatinib Mesylate Chemical Structure

CAS NO. 220127-57-1

Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.

Availability: In stock

Package Price Qty
100 mg

Regular Price: $60.00

Special Price $48.00

200 mg

Regular Price: $100.00

Special Price $80.00

500 mg

Regular Price: $160.00

Special Price $128.00

10mM * 1mL in DMSO
$63.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Details

Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.
Targets
PDGFR (Cell-free assay) c-Kit (M-07e cells) v-Abl (Cell-free assay)
100 nM100 nM600 nM
In vitro (25°C) DMSO 118 mg/mL (200.09 mM)
Water 118 mg/mL (200.09 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo Saline 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.96 mL 84.79 mL 169.58 mL
0.5 mM 3.39 mL 16.96 mL 33.92 mL
1 mM 1.7 mL 8.48 mL 16.96 mL
5 mM 0.34 mL 1.7 mL 3.39 mL

*The above data is based on the productmolecular weight 589.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Technical Details

Catalog Num A10468
Actions Inhibitor
M. Wt 589.7
Formula C29H31N7O.CH4SO3
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 220127-57-1
Synonyms Gleevec, Glivec, CGP-57148B, STI-571
SMILES CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O

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