Total item
Cart Subtotal
$0.00 Customer Appreciation Sale.
15% off with promo code "APPRECIATION2023" on check out or purchase order
- Inge Govaerts, .et al. PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia, J Hematol Oncol, 2021, 14: 97 PMID: 34167562
- Genevra Kuziel, .et al. Stromal CCL2 Signaling Promotes Mammary Tumor Fibrosis through Recruitment of Myeloid-Lineage Cells, Cancers (Basel), 2020, Jul 28;12(8):E2083 PMID: 32731354
Biological Activity
Imatinib mesylate, a selective tyrosine kinase inhibitor, induced a sustained objective response in treating gastrointestinal stromal tumors with the inhibition of the KIT signal-transduction pathway.
Targets
| PDGFR (Cell-free assay) | c-Kit (M-07e cells) | v-Abl (Cell-free assay) | ||
| 100 nM | 100 nM | 600 nM |
| In vitro | DMSO | 101 mg/mL (171.26 mM) | |
| Water | 101 mg/mL (171.26 mM) | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.96 mL | 84.79 mL | 169.58 mL |
| 0.5 mM | 3.39 mL | 16.96 mL | 33.92 mL |
| 1 mM | 1.7 mL | 8.48 mL | 16.96 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.39 mL |
*The above data is based on the productmolecular weight 589.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10468 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 220127-57-1 |
| Formula | C29H31N7O.CH4SO3 |
| M. Wt | 589.7 |
| Purity | >98% |
| Synonyms | Gleevec, Glivec, CGP-57148B, STI-571 |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC=CC(=N4)C5=CN=CC=C5.CS(=O)(=O)O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
Product Tags
Product Questions
Product Questions
No Questions
Keywords:buy Imatinib Mesylate | Imatinib Mesylate Supplier | purchase | cost | manufacturer | order | distributor | buy 220127-57-1| 220127-57-1 Supplier | purchase 220127-57-1 | 220127-57-1 cost | 220127-57-1 manufacturer | order 220127-57-1 | 220127-57-1 distributor
Adooq Quality Guarantee
We promise all products perform as described.