Catalog No.
Product Name
Application
Product Information
Citations
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Non-steroidal Anti-inflammatory Agent
Bermoprofen is an orally active non-steroidal anti-inflammatory agent that primarily exerts its effects through inhibition of prostaglandin synthesis. It demonstrates significant antipyretic activity, effectively reducing fever induced by lipopolysaccharides (LPS) in animal models. Due to its rapid onset and short biological half-life, Bermoprofen is applicable in research focused on inflammatory pathways and fever response mechanisms. -
Nonsteroidal anti-inflammatory drug
(R)-Ketoprofen is an orally active nonsteroidal anti-inflammatory drug (NSAID) with potent analgesic properties. It primarily targets cyclooxygenase enzymes to inhibit prostaglandin synthesis, thereby reducing pain and inflammation. (R)-Ketoprofen has been shown to modulate inflammatory cytokine responses, without significantly enhancing the levels of tumor necrosis factor (TNF) and interleukin-1 (IL-1) induced by lipopolysaccharide (LPS). This compound is widely utilized in research applications focused on pain management and inflammatory disease pathways. -
COX
ASP6537 is a selective inhibitor of recombinant human cyclooxygenase-1 (rhCOX-1), exhibiting an IC50 value of 0.703 nM. Its potent inhibition of COX-1 makes it a valuable tool for studying the role of prostaglandins in cardiovascular disease research. Researchers can utilize ASP6537 to investigate the effects of COX-1 modulation on cardiovascular pathophysiology. -
iNOS/COX-2 Inhibitor
Rehmapicrogenin is a selective inhibitor of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). This compound, derived from the root of Rehmannia glutinosa, demonstrates significant anti-inflammatory properties, making it a valuable tool for research focused on inflammation pathways. Its ability to inhibit pro-inflammatory mediators such as IL-6 further underscores its relevance in studies aimed at understanding and treating inflammatory diseases. -
COX-1/COX-2 Inhibitor
(S)-(+)-Ibuprofen-d3 is a deuterated analog of (S)-(+)-Ibuprofen, targeting the COX-1 and COX-2 enzymes. With IC50 values of 2.1 μM and 1.6 μM, respectively, this compound exhibits significant analgesic, anti-inflammatory, and antipyretic properties. It serves as a valuable tool for studying the pharmacodynamics and mechanisms of nonsteroidal anti-inflammatory drugs (NSAIDs) in various biological research applications. -
COX Inhibitor
Isoxicam is a non-steroidal anti-inflammatory drug (NSAID) that functions as a nonselective inhibitor of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2). Its primary mechanism involves the inhibition of prostaglandin synthesis, making it effective in reducing inflammation and pain. Isoxicam is commonly utilized in research related to arthritis and other inflammatory conditions, providing valuable insights into the role of COX enzymes in various biological processes. -
COX-2 Inhibitor
Cimicoxib is a selective COX-2 inhibitor that effectively penetrates the blood-brain barrier. It displays significant anti-inflammatory, analgesic, and antipyretic properties by inhibiting the production of thromboxane B2 and prostaglandin E2, with an IC50 of 66 nM against human COX-2. Additionally, Cimicoxib targets CYP2D15, exhibiting an IC50 of 1.6 μM in canines and 0.056 μM in felines. This compound is utilized in research involving inflammatory diseases, osteoarthritis, and perioperative pain management in orthopedic and soft tissue surgeries. -
COX Inhibitor
Naproxen glucuronide, a metabolite of naproxen, functions as a non-selective cyclooxygenase (COX) inhibitor. This compound exhibits significant anti-inflammatory, analgesic, and antipyretic activity, making it useful in the study of pain relief and inflammation pathways. Research applications include examining its metabolic pathways, assessing its efficacy in various inflammatory conditions, and exploring its pharmacokinetic properties in biological systems. -
Dual COX/5-LOX Inhibitor
ER-34122 is a dual inhibitor of cyclooxygenase (COX) and 5-lipoxygenase (5-LO). This compound exhibits significant anti-inflammatory activity, making it valuable for research into inflammation-related pathways. ER-34122 is particularly relevant for studies investigating the interplay between COX and 5-LO pathways in various disease models and therapeutic contexts. -
FAP Antagonist
R-75317 is a selective antagonist of platelet-activating factor (PAF). It has demonstrated the ability to prevent the decline in creatinine clearance in a rat model of antibody-induced glomerulonephritis, delay the onset of proteinuria, and ameliorate glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. This compound may serve as a valuable tool in the investigation of glomerulonephritis and related renal pathologies. -
mPGES-1 Inhibitor
Crisdesalazine is a selective inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). It demonstrates significant biological activity as a free radical scavenger, effectively neutralizing reactive oxygen species (ROS) such as hydrogen peroxide, thereby providing neuroprotective benefits against apoptosis and axonal damage. By inhibiting PGE2 production, Crisdesalazine also modulates inflammatory responses and facilitates the conversion of macrophages from the pro-inflammatory M1 to the anti-inflammatory M2 phenotype. This compound is particularly valuable for research focused on neuroprotection in conditions such as multiple sclerosis and spinal cord injury. -
NO/PGE2 Inhibitor
Epibetulinic acid is an inhibitor of nitric oxide (NO) and prostaglandin E2 (PGE2) production. It demonstrates significant anti-inflammatory activity, exhibiting IC50 values of 0.7 μM for NO and 0.6 μM for PGE2 in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin. This compound is valuable for research applications focused on inflammation and immune response modulation. -
Anti-inflammatory Agent
trans-Isoferulic acid, an aromatic acid and potent anti-inflammatory agent, is derived from the roots of Clematis florida var. plena. It effectively inhibits the production of nitric oxide (NO) and prostaglandin E2 (PGE2) by inducing Nrf2-dependent heme oxygenase-1 (HO-1). This compound is valuable for research applications focused on inflammation pathways and the modulation of oxidative stress. -
PGE2 Antagonist
SC-19220 is a competitive antagonist of the prostaglandin E2 receptor, demonstrating significant effects on bladder physiology. Research indicates that SC-19220 enhances bladder capacity while decreasing voiding efficiency in urethane-anesthetized rats during slow transvesical filling. Additionally, SC-19220 has been shown to restore the balance of granulocyte and monocyte production in bone marrow following burn sepsis, making it a valuable tool for investigations related to inflammatory responses and urinary tract function. -
5-LO/PGE2 Inhibitor
Canniprene is a potent inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase/microsomal prostaglandin E2 synthase (PGE2), with IC50 values of 0.4 μM and 10 μM, respectively. Derived from Cannabis sativa, Canniprene modifies the biosynthesis of inflammatory eicosanoids and prostaglandins, making it a valuable tool for researching inflammation and related pathways. Its unique mechanism of action positions Canniprene as a potential candidate for studying inflammatory diseases and therapeutic interventions targeting lipid mediators. -
PGE2 Inhibitor
Saikogenin D is an effective PGE2 inhibitor isolated from Bupleurum chinense. This compound exhibits significant anti-inflammatory properties by activating epoxygenases, leading to the conversion of arachidonic acid into epoxyeicosanoids and dihydroxyeicosatrienoic acids, which subsequently suppress PGE2 production. Saikogenin D also induces an increase in intracellular calcium levels ([Ca2+]i) through the release of Ca2+ from intracellular stores, making it a valuable tool for studying inflammatory pathways. -
COX-2 Inhibitor
Apricoxib is a selective inhibitor of cyclooxygenase-2 (COX-2), demonstrating a potent inhibitory effect on PGE2 production with an IC50 of 1.5 nM. This compound exhibits notable biological activities, including anticancer, analgesic, and anti-inflammatory properties. Apricoxib is a valuable tool for research applications focused on inflammation, pain management, and cancer therapeutics. -
PGE1 Analogue
SC 34301, an orally active PGE1 analogue, exhibits potent anti-inflammatory properties. It has been shown to significantly reduce bacterial translocation and enhance survival rates in burned mouse models. This compound is valuable for research applications focusing on inflammation, tissue repair, and the physiological effects of prostaglandin analogues. -
PGE2 Analog
Prostaglandin E2 Ethanolamide (PGE2-EA) is a biologically active analog of Prostaglandin E2, chiefly targeting the modulation of inflammatory responses. It is formed enzymatically through the COX-2-mediated oxygenation of endocannabinoids. PGE2-EA demonstrates the ability to influence the production of the pro-inflammatory cytokine TNF-α in human blood and monocytic cells, making it a valuable tool for research in inflammation and immunology. -
PGE2 Inhibitor
(+)-Oxypeucedanin methanolate is a potent inhibitor of prostaglandin E2 (PGE2) synthesis. This natural compound exhibits significant anti-inflammatory properties, making it a valuable reagent in studies focused on inflammation and pain modulation. Research applications include investigating the pathways of prostaglandin synthesis and exploring potential therapeutic interventions for inflammatory diseases. -
PGE2 Enantiomer
ent-Prostaglandin E2 (ent-PGE2) is an enantiomer of Prostaglandin E2 that serves as a poor substrate for 15-hydroxyprostaglandin dehydrogenase. This differential substrate activity can be leveraged in various biochemical studies to investigate the enzymatic pathways and regulatory mechanisms involving prostaglandins. Research applications include studying the physiological effects of PGE2 and the role of its enantiomers in inflammatory processes and cell signaling pathways. -
PGE1/PGE2 Metabolite
Tetranor-Prostaglandin E1 is a metabolite of Prostaglandin E1, resulting from β-oxidation processes. This compound serves as a crucial biomarker in studies related to prostaglandin metabolism and pathways. It is commonly utilized in research involving inflammatory responses and various physiological processes mediated by prostaglandins. -
PGE2 Precursor
Prostaglandin E2 isopropyl ester serves as a precursor for Prostaglandin E2 (PGE2). This compound is instrumental in various biological processes, including inflammation and modulation of immune responses. Researchers commonly utilize it in studies focused on prostaglandin synthesis and signaling pathways related to pain, edema, and cellular growth. Its role in mediating physiological functions makes it a valuable reagent for elucidating mechanisms in both basic and applied biomedical research. -
Nonsteroidal Anti-Inflammatory Agent
Amtolmetin guacil is a nonsteroidal anti-inflammatory agent that primarily targets cyclooxygenase (COX) to inhibit prostaglandin synthesis. It exhibits significant pain-relieving effects and has the added ability to stimulate capsaicin receptors in the gastrointestinal wall, promoting the release of gastroprotective nitric oxide (NO). This compound is particularly relevant for research focused on knee osteoarthritis and its associated inflammatory processes. -
PGE2 Antagonist
SC-42867 is a potent PGE2 antagonist, specifically designed to inhibit prostaglandin E2 signaling pathways. This compound is metabolized in the liver through mechanisms such as oxidative N-dealkylation and aromatic hydroxylation. SC-42867 is highly relevant for studies focused on metabolic conditions, allowing researchers to explore the biochemical implications of PGE2 modulation in various physiological processes. -
PGE2 Analogue
FCE 20700 is an orally active analogue of prostaglandin E2 (PGE2) that primarily targets gastric mucosal integrity. It demonstrates the ability to prevent gastric mucosal damage and inhibit both gastric acid and pepsin secretion. This compound is valuable for research into gastrointestinal ulcers and related disorders, providing insights into therapeutic strategies for gastrointestinal protection. -
NO/PGE2 Inhibitor
Salviifoside A is a phenolic glycoside that acts as an inhibitor of nitric oxide (NO) and prostaglandin E2 (PGE2) production. Isolated from the leaves of Alangium salviifolium, Salviifoside A effectively suppresses LPS-induced nitric oxide and prostaglandin E2 production in macrophages while maintaining cell viability. This compound is valuable for research focused on inflammatory responses and the modulation of macrophage activation. -
PGE2 Metabolite
13,14-Dihydro-15-keto-tetranor prostaglandin E2 is a novel metabolite of Prostaglandin E2, functioning primarily as a bioactive mediator in various physiological processes. As a key derivative, it is involved in studies exploring the metabolic pathways of prostaglandins and their implications in inflammation and other biological responses. This compound has significant applications in research focused on prostaglandin signaling and its role in disease mechanisms. -
PGE2 Analog
8-Iso-16-cyclohexyl-tetranor prostaglandin E2 is a PGE2 analog that exhibits potent biological activity by modulating various physiological processes. It engages the prostaglandin receptors, influencing pathways related to inflammation, pain, and vascular regulation. This compound is valuable for research applications focused on the roles of prostaglandins in disease models, as well as studies investigating receptor-targeted therapies. -
Anti-Inflammatory Agent
Diftalone, an anti-inflammatory agent, primarily targets inflammatory pathways to modulate immune responses. This compound is utilized in research investigating inflammatory diseases, including rheumatoid arthritis, and offers valuable insights into potential therapeutic approaches for managing such conditions. Its efficacy in reducing inflammation makes it a pivotal tool in the study of chronic inflammatory disorders. -
PGE1 Analog
15-Methylprostaglandin E1 is an analog of prostaglandin E1 (PGE1) that primarily targets prostaglandin receptors to elicit cardiovascular effects. It demonstrates a positive chronotropic effect, leading to increased heart rate and enhanced levels of nicardipine. This compound is widely utilized in studies related to circulatory system regulation and pharmacological investigations into heart rate modulation. -
Antiinflammatory Agent
4-Oxoetodolac, a metabolite of Etodolac, acts as an orally bioavailable anti-inflammatory agent. It effectively inhibits prostaglandin production in cultured chondrocyte cells, contributing to its anti-inflammatory properties. Additionally, 4-Oxoetodolac demonstrates moderate anti-inflammatory activity in a rat adjuvant edema model. This compound is useful for research focused on inflammation and related biological processes. -
PGE2 Analog
(15S)-15-Methylprostaglandin E2 is a synthetic analog of prostaglandin E2 that primarily targets the PGE2 receptor. This compound exhibits significant biological activity by promoting cytoprotection in gastrointestinal cells and may inhibit gastrointestinal bleeding. Its applications in research include studies on inflammation, gastrointestinal health, and the pharmacological roles of prostaglandins in various biological processes. -
PGE2 Inducer
5S(6R)-EET is a metabolite derived from arachidonic acid that acts as a potent inducer of prostaglandin E2 (PGE2) synthesis. This compound enhances intracellular calcium levels and inhibits sodium absorption, contributing to membrane depolarization. Its biological activity makes it a valuable tool for research focused on the regulatory roles of prostaglandins in various physiological processes. -
PGE2 Analog
16-Phenoxy tetranor Prostaglandin E2 is an analog of prostaglandin E2 (PGE2) that serves as a potent modulator of various biological processes. This compound exhibits significant biological activity by influencing the prostaglandin pathway, making it valuable for studying inflammatory responses and reproductive biology. Additionally, its role as a minor metabolite of sulprostone in human plasma provides insights into pharmacokinetics and metabolic pathways relevant to drug development and therapeutic applications. -
COX-2/PGE2 Inducer
Rebamipide-d4 is a deuterium-labeled derivative of Rebamipide, primarily targeting cyclooxygenase-2 (COX-2). This compound induces COX-2 expression and elevates prostaglandin E2 (PGE2) levels, thereby enhancing gastric mucosal defense mechanisms in a COX-2-dependent manner. Rebamipide-d4 is utilized in various research applications focused on gastric protection and the modulation of inflammatory responses. -
PGE2 Inducer
5R(6S)-EET is a metabolite derived from arachidonic acid that functions as a PGE2 inducer. It activates the synthesis of endogenous prostaglandin E2, leading to inhibition of sodium absorption, an increase in intracellular calcium levels, and enhanced depolarization of transmembrane voltage. This compound displays stereoselectivity, exhibiting differential activity compared to its stereoisomer, 5S(6R)-EET. Its biological effects make it a valuable tool for研究 applications focusing on prostaglandin signaling and related pathways. -
PGE1 Prodrug
Ecraprost is a prodrug of prostaglandin E1, designed to enhance the bioavailability of PGE1 in therapeutic applications. It effectively inhibits platelet adhesion and macrophage infiltration, as well as the expression of proliferating cell nuclear antigen in injured arterial walls. Ecraprost is utilized in research related to cardiovascular health and vascular injury repair. -
KRASG12C Inhibitor
KRASG12C IN-12 is a selective inhibitor of the KRASG12C mutant. This compound effectively forms a ternary complex with intracellular cyclophilin A (CYPA) and the activated KRASG12C, inhibiting its downstream signaling pathways. It has significant potential for research applications related to cancer biology, particularly in studies targeting KRAS-driven tumorigenesis. -
Anti-inflammatory agent
Pinolenic acid is a polyunsaturated fatty acid derived from the seed oils of Pinus orientalis and Pinus pinaster, primarily recognized for its anti-inflammatory properties. It has demonstrated significant lipid-lowering activities, making it valuable in research related to metabolic disorders and inflammation-related conditions. This compound serves as an important tool for exploring therapeutic interventions aimed at managing inflammatory responses and improving lipid profiles. -
TGR5 Agonist
Cholic acid 7-sulfate is a selective agonist for the TGR5 receptor with an EC50 of 0.17 μM. This compound enhances GLP-1 secretion in enteroendocrine L cells, leading to improved glucose tolerance through TGR5 activation. Additionally, as an endogenous ligand for MHC class I-related protein (MR1), it supports the survival of mucosal-associated invariant T (MAIT) cells and influences their development and function by modulating homeostatic gene expression. Cholic acid 7-sulfate is valuable in studies related to diabetes and MAIT cell-mediated immune regulation. -
Stable Isotope
Cholic acid 7-sulfate-d4 is a deuterium-labeled derivative of cholic acid 7-sulfate, a selective agonist for the TGR5 receptor with an EC50 of 0.17 μM. This compound plays a crucial role in stimulating GLP-1 secretion and enhancing glucose tolerance through its action on enteroendocrine L cells. Additionally, cholic acid 7-sulfate-d4 serves as an endogenous ligand for MHC class I-related protein (MR1), influencing the development and function of mucosal-associated invariant T cells (MAIT). It is primarily utilized in research focused on diabetes and immune regulation related to MAIT cells. -
Anti-inflammatory Agent
EA-230 is a synthetic oligopeptide derived from beta-human chorionic gonadotropin (beta-hCG) lysates, serving as an anti-inflammatory agent. It exhibits significant anti-inflammatory properties, making it valuable for research focused on sepsis and related inflammatory conditions. EA-230 is useful in elucidating the mechanisms of inflammation and developing potential therapeutic strategies. -
Antiinflammatory Agent
Ibuprofen alcohol is a nonsteroidal anti-inflammatory agent (NSAID) that primarily functions by inhibiting cyclooxygenase enzymes, leading to a decrease in the synthesis of prostaglandins. It exhibits potent anti-inflammatory activity, making it useful in studies related to pain management and inflammation. This compound serves as a valuable tool in understanding the biochemical pathways involved in inflammatory responses. -
Anti-inflammatory Agent
Salnacedin is an anti-inflammatory agent that exhibits keratolytic activity. It has demonstrated efficacy in reducing inflammation, making it suitable for the study of conditions such as seborrhoeic dermatitis and acne. Researchers can utilize Salnacedin to investigate its therapeutic potential and underlying mechanisms in dermatological disorders. -
PGE1 Metabolite
13,14-Dihydro-15-keto-PGE1 is a metabolite of prostaglandin E1 (PGE1) that exhibits inhibitory effects on platelet aggregation. It has been shown to inhibit ADP-induced aggregation in human isolated platelet-rich plasma with an IC50 value of 14.8 μg/mL. This compound is useful in research applications focusing on thrombotic disorders and the role of prostaglandins in platelet function. -
Etoricoxib Metabolite
Etoricoxib N1'-oxide is a metabolite of Etoricoxib that serves as an important biochemical marker in pharmacological studies. This compound is notable for its lack of inhibition on both COX-1 and COX-2 enzymes, making it a valuable tool for researchers investigating the metabolic pathways and safety profiles of COX inhibitors. Its characterization can aid in understanding the pharmacodynamics and pharmacokinetics of Etoricoxib in clinical settings. -
Anti-inflammatory/Antioxidant
1-(4-Methoxyphenyl)-1-propanol is an orally active derivative of anethole, primarily exhibiting anti-inflammatory and antioxidant properties. It demonstrates significant antioxidant activity and has been shown to possess anti-inflammatory effects alongside moderate gastric protective activity in mouse models. This compound is useful for studying gastric ulcers and related gastrointestinal conditions in research applications. -
Anti-inflammatory Agent
Phochinenin K is a 9,10-dihydrophenanthrene derivative that demonstrates significant anti-inflammatory activity. Isolated from the rhizomes of Bletilla formosana, this compound is suitable for research applications focused on understanding the mechanisms of inflammatory diseases and developing therapeutic strategies. Its unique properties make it a valuable reagent for studying inflammation-related pathways. -
Antiinflammatory Agent
Aristololactam IIIa functions as an anti-inflammatory agent by effectively inhibiting superoxide anion generation and elastase release, demonstrating IC50 values of 0.12 and 0.20 μg/mL, respectively. This compound is valuable in research applications focused on oxidative stress and inflammatory responses, making it suitable for studying various inflammatory diseases.
