Catalog No.
Product Name
Application
Product Information
Citations
- Prostaglandin F2α is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
- Michel R Corboz, .et al. , Prostaglandins Other Lipid Mediat, 2020, Oct 1;152:106486 PMID: 33011365
- Loxoprofen is a non-steroidal anti-inflammatory drug.
- Takashi Azuma, .et al. , SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
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COX inhibitor
Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels. - 21-Deacetoxy Deflazacort is an intermediate of Deflazacort, a systematic corticosteroid.
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anti-inflammatory
Amodiaquine hydrochloride is a 4-aminoquinoquinoline compound with anti-inflammatory properties. -
anti-inflammatory (NSAID) agent
Ibuprofen piconol is a non-steroidal, anti-inflammatory (NSAID) agent for the topical relief of primary thermal burns and sunburns. - Benzydamine Hcl is a locally-acting nonsteroidal anti-inflammatory drug with local anaesthetic and analgesic properties; selectively binds to prostaglandin synthetase and has notable in vitro antibacterial activity.
- Anti-Inflammatory Peptide 1, belongs to the group of synthetic oligopeptides corresponding to a region of high amino-acid sequence similarity between uteroglobin and lipocortin I.
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Immunomodulator
Aceneuramic acid is an immunomodulator potentially for treatment of hereditary inclusion body myopathy (HIBM). -
Antioxidant/Anti-inflammatory Agent
S-Allylmercaptocysteine is an organic sulfur compound that acts as both an antioxidant and anti-inflammatory agent. This compound exhibits significant efficacy in various pulmonary diseases by reducing oxidative stress and inflammation. S-Allylmercaptocysteine also demonstrates potential anti-cancer activity by inducing apoptosis in cancer cells via the TGF-β signaling pathway, while modulating NF-κB activity and up-regulating Nrf2 to enhance its therapeutic effects. -
Anti-inflammatory Agent
Sodium taurodeoxycholate hydrate is an anionic detergent derived from bile salts, primarily acting as an anti-inflammatory agent. Its key biological activity includes facilitating the isolation of membrane proteins, particularly those associated with the inner mitochondrial membrane. Additionally, sodium taurodeoxycholate hydrate exhibits neuroprotective properties, making it useful in various research applications related to inflammation and neurobiology. -
Anti-Inflammatory Agent
Cannflavin A is a natural flavonoid extracted from Cannabis sativa L., primarily functioning as an anti-inflammatory agent. It exhibits significant anti-cancer and neuroprotective properties, inhibiting Aβ1-42 aggregation and demonstrating activity against kynurenine-3-monooxygenase with an IC50 of 29.4 μM. Cannflavin A promotes apoptosis through caspase-3 cleavage and effectively reduces inflammation by targeting pro-inflammatory enzymes such as prostaglandin E2 and cytochrome c oxidases I and II in PC12 cell line studies. This compound is valuable for research related to inflammatory diseases and neurodegenerative disorders. -
Anti-inflammatory Agent
Aloesone is a phenolic compound that serves as an anti-inflammatory agent. It effectively inhibits the production of reactive oxygen species (ROS), the release of nitric oxide (NO), M1 polarization, and apoptosis in LPS-stimulated RAW264.7 cells. This compound exhibits notable anti-inflammatory and antioxidant properties, making it a valuable tool for research in inflammation and oxidative stress. -
Anti-inflammatory Agent
[D-Leu-4]-OB3 is an anti-inflammatory agent that selectively inhibits the expression of pro-inflammatory, proliferative, and metastatic genes while downregulating PD-L1 expression. Additionally, it promotes the expression of pro-apoptotic genes, contributing to its potential in cancer research. This compound is valuable for studies focused on inflammatory responses and cancer progression. -
Anti-inflammatory Agent
Delphinidin-3-sambubioside chloride is a naturally occurring anthocyanin recognized for its anti-inflammatory properties. This compound effectively inhibits the release of inflammatory factors induced by lipopolysaccharides (LPS) and demonstrates the ability to reduce hepatic lipid accumulation in high-fat diet rat models. Delphinidin-3-sambubioside chloride is extracted from Hibiscus sabdariffa L. and serves as a valuable tool for studying inflammation-related biological processes. -
Antiinflammatory Agent
Resolvin D3 (RvD3) is a bioactive mediator derived from docosahexaenoic acid (DHA) with potent anti-inflammatory properties. This compound plays a crucial role in resolving inflammation, making it particularly relevant for research into inflammatory conditions such as arthritis. By modulating immune responses, Resolvin D3 facilitates the resolution of inflammation, providing insights into therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
Fmoc-Leucine, an anti-inflammatory agent, functions primarily as a selective ligand for PPARγ, with a binding affinity (Ki) of 15 μM. It promotes both extracellular Ca2+ influx and intracellular Ca2+ release while exhibiting insulin-sensitizing effects with minimal fatogenic activity. This compound demonstrates unique self-assembly characteristics, forming transient gels, stable gels, or crystals/2D sheets under varying conditions. Fmoc-Leucine is valuable for research related to diabetes, colitis, and bladder cancer. -
Anti-inflammatory Agent
Hexadecanamide is a fatty acid amide that serves as an anti-inflammatory agent, exhibiting protective effects against Staphylococcus aureus and SARA-induced mastitis. It functions by suppressing S. aureus-mediated NF-κB activation and enhancing blood-milk barrier integrity. Additionally, Hexadecanamide activates PPARα and has been shown to improve sperm motility in vitro. This compound is relevant for research applications involving mastitis and asthenozoospermia. -
Anti-Inflammatory/Cancer Agent
Norathyriol is a natural metabolite derived from Mangifera, exhibiting significant anti-inflammatory and anticancer properties. It functions as a noncompetitive inhibitor of α-glucosidase with an IC50 value of 3.12 μM. Additionally, Norathyriol inhibits the peroxisome proliferator-activated receptors (PPARs) α, β, and γ, with IC50s of 92.8 μM, 102.4 μM, and 153.5 μM, respectively. This compound demonstrates a range of biological activities, including antioxidant, antimicrobial, and antibacterial effects, making it valuable for diverse research applications in inflammation and cancer therapeutics. -
Anti-inflammatory
1-O-Hexadecylglycerol serves as an anti-inflammatory agent by upregulating PPAR-γ expression and inhibiting prostaglandin E2 (PGE2) synthesis. This compound demonstrates significant biological activity in reducing inflammation and is suitable for various research applications focused on inflammatory processes. Its efficacy is noted in oral administration, facilitating its potential use in preclinical studies and therapeutic exploration. -
Anti-inflammatory Agent
Adelmidrol is an anti-inflammatory agent that primarily targets peroxisome proliferator-activated receptor gamma (PPARγ). This compound mediates significant reductions in NF-κB translocation and COX-2 expression, contributing to its anti-inflammatory effects. Adelmidrol is utilized in research focused on inflammation pathways and therapeutic potential in various inflammatory conditions. -
Anti-Inflammatory Agent
3-Aminoisobutyric acid is an anti-inflammatory agent that exhibits both anti-inflammatory and antioxidant properties. It enhances the expression of genes associated with brown adipocytes in white adipose tissue and promotes fatty acid β-oxidation in hepatocytes. Additionally, 3-Aminoisobutyric acid mitigates insulin resistance and inflammation triggered by palmitate or a high-fat diet through an AMPK-PPARδ-dependent pathway in murine models. This compound also serves as a catabolic metabolite of thymine and valine within skeletal muscle, making it relevant for metabolic research. -
Anti-Inflammatory Agent
Romazarit, a PPARα agonist, serves as an effective anti-inflammatory agent with demonstrated antirheumatic properties. In studies, Romazarit has been shown to inhibit the development of hindpaw inflammation at a dosage of 30 mg/kg in an adjuvant arthritis model. This compound is of interest for research applications focusing on inflammatory diseases and therapeutic interventions in arthritis. -
Anti-inflammatory Agent
(3R,5R)-3,5-Dihydroxy-1,7-bis(3,4-dihydroxyphenyl)heptane 3-O-β-D-glucopyranoside functions as an anti-inflammatory agent. This diarylheptanol glycoside, derived from Tacca plantaginea, effectively inhibits TNF-α-induced NF-κB transcriptional activity with an IC50 of 9.4 μM. Additionally, it activates PPAR transcriptional activity (EC50 = 9.9 μM) and exhibits a specific activating effect on PPAR β(δ) with an EC50 of 23.1 μM. Non-toxic to cells at tested concentrations, this compound is suitable for research on inflammatory conditions. -
Anti-inflammatory Agent
3-Demethylcolchicine is an anti-inflammatory agent known for its potent tubulin-binding activity. This colchicine metabolite effectively inhibits carrageenan-induced edema in rat paw models, making it valuable for research into inflammatory responses. Additionally, the presence of a hydroxyl group on its carbocyclic ring enhances its ability to scavenge free radicals, contributing to its therapeutic potential. 3-Demethylcolchicine serves as a key reagent in studies focused on inflammation and oxidative stress. -
Anti-inflammatory compound
U-83836E is an anti-inflammatory compound that exhibits both anti-inflammatory and antioxidant activities. It effectively reduces lung inflammation by inhibiting oxidative stress and the production of reactive oxygen species (ROS). This compound is valuable for research applications focused on asthma and lung inflammation in various animal models. -
Anti-inflammatory Agent
Kumujian A (1-Ethoxycarbonyl-β-carboline) is an anti-inflammatory agent that effectively inhibits superoxide anion generation with an IC50 of 4.87 μg/mL and elastase release with an IC50 of 6.29 μg/mL. This compound is valuable for research applications focused on understanding inflammation pathways and developing potential therapeutic strategies for inflammatory diseases. -
Nonsteroidal Anti-inflammatory Agent
Feprazone is a nonsteroidal anti-inflammatory agent that targets cyclooxygenase-2 (COX-2), exhibiting significant analgesic and antipyretic properties. This compound has been shown to mitigate oxidative stress induced by free fatty acids by reducing mitochondrial reactive oxygen species (ROS) production. Additionally, Feprazone inhibits the expression of matrix metalloproteinases MMP-2 and MMP-9, while suppressing adipogenesis and promoting lipolysis in differentiating 3T3-L1 adipocytes. It is valuable for research applications focused on atherosclerosis and obesity. -
Anti-Inflammatory Compound
Dapsone hydroxylamine (DDS-NOH) is an anti-inflammatory compound that primarily targets catalase (CAT) activity. It inhibits CAT activity and reduces the generation of reactive oxygen species, contributing to its anti-inflammatory properties. Dapsone hydroxylamine is utilized in research applications focused on oxidative stress and inflammation modulation. -
Anti-Neuroinflammatory Agent
LZWL02003 is an anti-neuroinflammatory agent that targets neuroinflammatory pathways. It demonstrates protective effects against MPP+-induced neuronal damage and significantly reduces reactive oxygen species (ROS) levels. Additionally, LZWL02003 enhances cognitive functions such as memory, learning, and physical performance in a Rotenone-induced parkinsonism model in rats. This compound is valuable for research into neurodegenerative diseases and potential therapeutic interventions. -
Anti-inflammatory Agent
3′-Oxolutein is an anti-inflammatory agent and a metabolite of dietary lutein. It effectively reduces glutamate-induced reactive oxygen species (ROS) production and pro-inflammatory cytokine secretion in SH-SY5Y cells. Additionally, 3′-Oxolutein decreases glutamate-induced iron levels while enhancing thiol concentrations. This compound is suitable for research focused on inflammation and oxidative stress responses. -
Anti-inflammatory Agent
Pholidotol C is a stilbene compound that serves as an anti-inflammatory agent by inhibiting nitric oxide (NO) production. It demonstrates significant antioxidant properties, with IC50 values of 28.6 μM for NO production and 21.9 μM for DPPH free radical scavenging. Pholidotol C's mechanisms include the inhibition of NO production in activated macrophages and effective free radical scavenging. This compound is valuable for research in inflammation-related diseases and can be extracted from the dried whole plant of Pholidota chinensis. -
Anti-inflammatory Agent
Anti-inflammatory agent 21 is an orally active compound that targets the inflammatory response through its inhibitory effects on nitric oxide production, demonstrating an IC50 value of 0.76 μM. This agent induces reactive oxygen species accumulation and effectively blocks the NF-κB/MAPK signaling pathway. Research applications include investigating its potential to mitigate cartilage destruction and reduce inflammatory cell infiltration in models of arthritis. -
Inflammatory Biomarker
8-Bromo-2'-deoxyguanosine is a halogenated DNA adduct associated with inflammation, serving as an early biomarker for oxidative tissue damage linked to inflammatory processes. Its formation precedes the generation of other oxidative and nitrative stress products and can be synthesized through the MPO-H2O2-Cl−-Br− system. This compound plays a critical role in detecting early DNA modifications using the monoclonal antibody mAb8B3, suitable for preclinical research. Additionally, its urinary levels are significantly elevated in various inflammatory disease models, making 8-Bromo-2'-deoxyguanosine valuable for investigations into inflammatory diseases, diabetes, hepatocellular carcinoma, and UV-B induced skin injuries. -
Anti-Inflammatory Agent
Vitisin A is a resveratrol tetramer with potent anti-inflammatory properties. It exerts its biological activity by inhibiting LPS-induced nitric oxide (NO) and inducible nitric oxide synthase (iNOS) production through the down-regulation of ERK1/2, p38, and NF-κB signaling pathways. Additionally, Vitisin A demonstrates antioxidative, anticancer, and neuroprotective effects while also inhibiting adipocyte differentiation. This compound is derived from the roots of Vitis vinifera and serves as a valuable reagent for research in inflammation and related diseases. -
Anti-inflammatory Agent
24-O-Acetyllycoclavanol is a triterpenoid compound that functions as an anti-inflammatory agent by selectively targeting the NF-κB and ERK1/2 signaling pathways. Its biological activity includes the inhibition of lipopolysaccharide (LPS)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to decreased production of inflammatory mediators like nitric oxide (NO), IL-1β, and IL-8. This compound is particularly relevant for research applications in the context of inflammatory bowel disease (IBD) and can be isolated from the ethyl acetate extract of Lycopodium clavatum. -
Anti-inflammatory Agent
Anti-inflammatory agent 31 is a derivative of andrographolide that functions primarily by inhibiting NF-κB activation through the upstream blockade of the PI3K/Akt and ERK1/2 MAPK signaling pathways. This compound exhibits notable anti-inflammatory activity, promoting the recovery of intracellular glutathione (GSH) levels. Additionally, anti-inflammatory agent 31 demonstrates a protective effect on liver cells, making it a valuable tool for research applications in inflammation and hepatoprotection. -
Antioxidant/Anti-inflammatory/Anticancer Agent
Licoflavanone, a flavanone with antioxidant, anti-inflammatory, and anticancer properties, is isolated from the leaf extract of Glycyrrhiza glabra. It exerts its anticancer effects by downregulating the mTOR/PI3K/AKT signaling pathway, leading to inhibition of cancer cell proliferation, migration, and invasion. Additionally, Licoflavanone activates pro-apoptotic factors such as Bax and Bad, along with multiple caspase enzymes. Its anti-inflammatory activity involves reducing NF-κB nuclear translocation and decreasing the phosphorylation of p38, JNK, and ERK1/2, ultimately inhibiting pro-inflammatory cytokines, COX-2, and iNOS expression. This compound is utilized in research on nasopharyngeal carcinoma and its underlying mechanisms. -
Anti-inflammatory Agent
Centaureidin is an orally active anti-inflammatory agent derived from Bidens pilosa, exhibiting an EC50 of 0.9 μg/mL as an IFN-promoter. This compound activates the Rho signaling pathway, resulting in actin and tubulin disassembly, which leads to dendritic retraction and the formation of stress fibers in melanocytes. Centaureidin demonstrates potent inhibitory effects on tumor cell growth and has been shown to significantly reduce paw edema in murine models, highlighting its potential utility in inflammatory and anticancer research. -
Anti-inflammatory Agent
(7'E,8S)-2',4,8-Trihydroxy-3-methoxy-2,4'-epoxy-8,5'-neolign-7'-en-7-one is an anti-inflammatory agent targeting hepatic stellate cells. With an IC50 of 25.2 μM against TGF-β-induced HSC-T6 cells, this compound is instrumental in studies related to liver fibrosis by inhibiting excessive cell proliferation. Isolated from the dried aerial parts of Penthorum chinense Pursh, it holds potential for research into liver fibrosis-related conditions. -
Anti-inflammatory Agent
Anti-inflammatory Agent 58 is a potent inhibitor of IL-1β, demonstrating an IC50 of 1.08 μM. This compound effectively reduces pro-inflammatory gene expression, limits protein secretion, and inhibits NF-κB phosphorylation. It is suitable for research applications focused on inflammatory pathways and the modulation of immune responses. -
Anti-inflammatory Agent
Pseudoginsenoside RT4 is an orally active tetracyclic triterpenoid with notable anti-inflammatory properties. It effectively reduces the levels of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, while enhancing IL-10 levels. Additionally, Pseudoginsenoside RT4 modulates gut microbiota composition, making it a valuable reagent for research related to ulcerative colitis and other inflammatory conditions. Its multifaceted mechanism of action positions it as a significant tool in the study of anti-inflammatory pathways. -
Anti-inflammatory Agent
Anti-inflammatory agent 59 is a selective inhibitor of interleukin-1 beta (IL-1β) with an IC50 of 2.28 μM. This compound effectively reduces pro-inflammatory gene expression and protein secretion while inhibiting NF-κB phosphorylation. It serves as a valuable tool in the study of inflammatory pathways and may aid in the development of new therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
Acutissimalignan B is a bioactive compound recognized for its role as an anti-inflammatory agent. It effectively reduces the mRNA expression of key inflammatory cytokines, including inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). Additionally, Acutissimalignan B inhibits the phosphorylation of IκBα and the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65, thereby demonstrating potential utility in neuroinflammation research and related disease models. -
Anti-inflammatory Agent
Linderaspirone A is a natural compound derived from the roots of Lindera aggregate that functions as an anti-inflammatory agent. It exhibits significant inhibitory effects on the production of pro-inflammatory mediators, including prostaglandin E2 (PGE2), TNF-α, and IL-6. This compound can be utilized in research applications focused on understanding the mechanisms of inflammation and developing therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Peptide
IIIM1 is an orally active anti-inflammatory peptide that functions by stimulating the proliferation of regulatory T cells and promoting the production of RA1. This molecule effectively ameliorates symptoms associated with experimental autoimmune encephalomyelitis (EAE) by regulating cytokine balance. IIIM1 is a valuable tool for research focused on multiple sclerosis (MS) and its underlying immunological mechanisms. -
Anti-Inflammatory Agent
Dactyllactone A is an isoquinoline alkaloid derived from Dactylicapnos scandens that functions as a potent anti-inflammatory agent. It effectively inhibits the expression of pro-inflammatory cytokines such as IL-1β and prostaglandins, including PGE2. This compound is valuable for research applications focused on inflammatory pathways and the exploration of therapeutic interventions in inflammatory diseases.
