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Immunology & Inflammation

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Items 1-50 of 1427

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  1. A15801
    Entrectinib

    TRK, ROS1, ALK inhibitor

    Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity.
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  2. A12258
    HPGDS inhibitor 1

    HPGDS inhibitor

    HPGDS inhibitor 1 is a novel and selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.
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  3. A13343
    Zinc Protoporphyrin

    HO-1 inhibitor

    Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is a competitive heme oxygenase-1 (HO-1) inhibitor, markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2.
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  4. A14433
    GKT137831

    NOX1/4 inhibitor

    GKT137831 is a first in class inhibitor targeting NOX1 and NOX4 enzymes.
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  5. A12043
    (-)-Epicatechin

    COX-1 inhibitor

    (-)-Epicatechin is a natural product from green tea. (-)Epicatechin is an inhibitor of Cox-1
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  6. A11768
    Radicicol

    Hsp90/SRC/COX-2 Inhibitor

    Radicicol is a potent inhibitor of Hsp90, SRC, and Cox-2
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  7. A15381
    NFAT Inhibitor

    NFAT inhibitor

    NFAT Inhibitor, selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT).
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  8. A10461
    Ibuprofen (Advil)

    COX-1 inhibitor

    Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) targeting COX-1 with an IC50 of 13 μM.
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  9. A18591
    GB1107

    Gal-3 inhibitor

    GB1107 is a potent, selective, orally active inhibitor of Galectin-3 (Gal-3) with a Kd of 37 nM for human Galectin-3. GB1107 reduces human and mouse lung adenocarcinoma growth and blocks metastasis in the syngeneic model.
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  10. A19399
    CADD522

    RUNX2-DNA binding inhibitor

    CADD522 is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM. CADD522 exhibits antitumor activity.
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  11. A10030
    Acetaminophen

    COX inhibitor

    Acetaminophen (paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic drug. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor.
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  12. A11989
    Apocynin (Acetovanillone)

    NADPH-oxidase inhibitor

    Apocynin is a NADPH oxidase inhibitor
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  13. A17172
    ML-385

    NRF2 inhibitor

    ML-385 is an inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2) with IC50 value of 1.9 μM.
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  14. A15163
    MK-0591 (Quiflapon)

    FLAP inhibitor

    MK-0591 is a selective and specific 5-Lipoxygenase-activating protein (FLAP) inhibitor with an IC50 value of 1.6 nM in a FLAP binding assay.
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  15. A12383
    Reparixin

    CXCL8/CXCR1/2 Inhibitor

    Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM).
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  16. A10371
    Etodolac (AY-24236)

    COX inhibitor

    Etodolac (AY-24236) is a non-steroidal anti-inflammatory compound that is a non-selective inhibitor of COX (IC50=53.5 nM).
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  17. A17160
    TLR2-IN-C29

    TLR Inhibitor

    TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling.
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  18. A18704
    Asymmetric dimethylarginine

    NOS inhibitor

    Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase (NOS), and functions as a marker of endothelial dysfunction in a number of pathological states.
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  19. A10474
    Indomethacin (Indocid, Indocin)

    COX inhibitor

    Indomethacin is a nonselective COX1 and COX2 inhibitor with IC50 of 0.1 μg/mL and 5 μg/mL, respectively. Indomethacin(Indocid, Indocin) is a non-steroidal anti-inflammatory compound commonly used to reduce fever, pain, stiffness, and swelling.
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  20. A21984
    Sulforaphane

    HDAC inhibitor

    Sulforaphane activates Nrf2 and inhibits high glucose-induced progression of pancreatic cancer via AMPK dependent signaling. Sulforaphane has shown anti-cancer and anti-inflammatory activities.
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  21. A10782
    Rapamycin (Sirolimus)

    mTOR Inhibitors

    Rapamycin (Sirolimus) prevents activation of T cells and B-cells by inhibiting their response to interleukin-2 (IL-2).
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  22. A10749
    Pravadoline (WIN 48098)

    COX inhibitor

    Pravadoline (WIN 48,098) is antiinflammatory and prostaglandin synthesis inhibitor, acting through inhibition of the enzyme cyclooxygenase (COX).
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  23. A13171
    NOD-IN-1

    NOD-like receptors inhibitor

    NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC50 of 5.74 μM and 6.45 μM, respectively.
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  24. A11697
    Licofelone

    COX/LOX inhibitor

    Licofelone is a dual COX/LOX inhibitor, being considered as a treatment for osteoarthritis. It may reduce the gastrointestinal toxicity associated with other non-steroidal anti-inflammatory drugs, which only inhibit COX (cyclooxygenase). Licofelone is the first drug to inhibit both.
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  25. A13478
    MCC950 sodium

    NLRP3 inhibitor

    MCC950 sodium is a potent NLRP3 inflammasome inhibitor that inhibits IL-1beta production with IC50 value of 7.5 nm.
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  26. A15205
    Paradol

    COX-1 Inhibitor

    Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta); Paradol has been found to have antioxidative and antitumor promoting effects
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  27. A10389
    FK-506 (Tacrolimus)

    mTOR inhibitor

    FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.
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  28. A17555
    Ciprofloxacin hydrochloride hydrate

    Topoisomerase IV inhibitor

    Ciprofloxacin Hydrochloride is a broad-spectrum antimicrobial carboxyfluoroquinoline, interfering with the bacterial DNA gyrase, inhibiting the DNA synthesis, and preventing bacterial cell growth.
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  29. A18905
    Iptacopan (LNP023)

    Factor B inhibitor

    LNP023 is a highly potent factor B (FB) inhibitor with an IC50 value of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human FB (KD=7.9 nM).
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  30. A12434
    (S)-(+)-Flurbiprofen

    COX inhibitor

    (S)-(+)-Flurbiprofen is a non-selective Cox-1 and Cox-2 inhibitor.
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  31. A11686
    Flunixin meglumine

    COX inhibitor

    Flunixin Meglumin is a potent inhibitor of the enzyme cyclooxygenase (COX) used as analgesic agent with anti-inflammatory and antipyretic activity.
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  32. A12520
    Meclofenamate Sodium

    COX inhibitor

    Meclofenamate Sodium is a dual COX-1/COX-2 inhibitor with IC50 of 40 nM and 50 nM.
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  33. A12548
    VGX-1027

    TLR4 Inhibitor

    VGX-1027 displays immunomodulatory and anti-inflammatory activities by inhibiting toll-like receptor 4 (TLR4) signaling.
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  34. A12561
    Nrf2-IN-1

    Nrf2 inhibitor

    Nrf2-IN-1 (Compound 4f) is an inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2), acts as a promising agent in acute myeloid leukemia (AML) therapy.
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  35. A12596
    MSX-122

    CXCR4 Inhibitor

    MSX-122 is an orally bioavailable inhibitor of CXCR4 (IC50 = ~10 nM) with potential antineoplastic and antiviral activities. CXCR4 inhibitor MSX-122 binds to the chemokine receptor CXCR4, preventing the binding of stromal derived factor-1 (SDF-1) to the CXCR4 receptor and receptor activation, which may result in decreased tumor cell proliferation and migration.
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  36. A12710
    Gw274150

    iNOS Inhibitor

    GW274150 is a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury.
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  37. A12879
    Tepoxalin

    COX/5-LOX inhibitor

    Tepoxalin is a dual cyclooxygenase/5-lipoxygenase inhibitor of arachidonic acid metabolism with potent anti-inflammatory activity and a favorable gastrointestinal profile
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  38. A12928
    MI 2

    MALT1 inhibitor

    MI 2 binds directly to MALT1 and suppresses activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) in vitro and in vivo.
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  39. A12986
    Ac-Gly-BoroPro

    FAP inhibitor

    Ac-Gly-BoroPro is a selective FAP inhibitor with a Ki of 23 nM.
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  40. A13023
    SC 560

    COX-1 inhibitor

    SC 560 is a COX-1 selective inhibitor, which can be used as a pharmacological tool to study the role of COX-1-derived PGs in inflammation and pain.
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  41. A13027
    L-NIO dihydrochloride

    NOS inhibitor

    L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor.
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  42. A13032
    AT 56

    L-PGDS inhibitor

    AT-56 is am orally active inhibitor of lipocalin-type prostaglandin D synthase (L-PGDS) (Ki = 75 μM, IC50 = 95 μM).
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  43. A13052
    Naproxen etemesil

    COX-1 and COX-2 inhibitor

    Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay.
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  44. A13116
    NS-398

    COX-2 inhibitor?€?

    NS-398 is a non-steroidal an-inflammatory agent with analgesic and antipyretic effects, and selectively inhibits prostaglandin G/H synthase 2/cyclooxygenase 2 (COX-2) activity, with an IC50 of 3.8 μM, and has no effect on COX-1 at 100 μM.
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  45. A13129
    BMS-1166

    PD-1/PD-L1 interaction inhibitor

    BMS-1166 is a potent PD-1/PD-L1 interaction inhibitor with an IC50 of 1.4 nM. BMS-1166 antagonizes the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
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  46. A13147
    MD2-IN-1

    MD2 inhibitor

    MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 ?μM for the recombinant human MD2 (rhMD2).
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  47. A13244
    Bromfenac sodium

    COX-2 inhibitor

    Bromfenac sodium is a topically selective cyclooxygenase (COX)-2 inhibitor
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  48. A13332
    FK 3311

    COX-2 Inhibitor

    FK3311 is a cell-permeable and orally available sulfonanilide that acts as a selective COX-2 inhibitor and NSAID.
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  49. A13333
    Flufenamic acid

    COX inhibitor

    Flufenamic acid is a nonsteroidal anti-inflammatory drug (NSAID). Inhibits calcium-activated chloride channels (CaCCs). Also increases currents through TRPC6 channels and inhibits currents through TRPC3 and TRPC7 channels.
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  50. A13340
    Tenidap

    COX-1 inhibitor

    Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 ?M and 1.2 ?M for COX-1 and COX-2, respectively.
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