Catalog No.
Product Name
Application
Product Information
Citations
-
Stable Isotope
4-Methyl-2-(1-piperidinyl)-quinoline-d10 is a deuterated analogue of ML204, functioning as a selective inhibitor of the TRPC4 and TRPC5 ion channels. This compound exhibits a significant 19-fold selectivity over TRPC6 and has minimal impact on other TRP channels, as well as voltage-gated sodium, potassium, and calcium channels. It is a valuable tool for investigating TRPC channel functions and their roles in various biological processes. -
Stable Isotope
(-)-Menthol-d4 is a deuterium-labeled derivative of (-)-Menthol, a significant constituent of peppermint oil. It acts as an agonist for the transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, leading to an increase in intracellular calcium levels. This compound is utilized in research to explore its biological activity, particularly its potential antitumor effects and mechanisms of action involving sensory signaling pathways. -
Isotope-Labeled Compounds
Verapamil-d7 is a deuterium-labeled derivative of Verapamil, a calcium channel blocker and a potent inhibitor of the P-glycoprotein (P-gp) transporter. This isotope-labeled compound is utilized in pharmacokinetic studies and metabolic research, providing insights into drug interactions and transport mechanisms. Its applications extend to investigating conditions such as hypertension, cardiac arrhythmias, and angina, making it a valuable tool in cardiovascular research. -
Stable Isotope
Ethosuximide-d5 is a stable isotopically labeled form of Ethosuximide, an established anti-epileptic agent. This compound acts primarily as a blocker of low voltage activated T-type calcium channels, contributing to its therapeutic effects. Ethosuximide-d5 is valuable for research applications involving neurodegenerative disease models and mechanisms of epilepsy, enabling precise metabolic studies and tracking within biological systems. -
Stable Isotope
Diltiazem-(acetoxy-d3) hydrochloride is a deuterium-labeled derivative of Diltiazem hydrochloride, a calcium channel antagonist. As a stable isotope compound, it serves as a valuable tool for pharmacokinetic studies and metabolic research, allowing for precise tracking of Diltiazem's biological fate. This reagent can facilitate investigations into calcium signaling pathways and cardiovascular pharmacology. -
Stable Isotope
Levamlodipine-d4 is the deuterium-labeled form of Levamlodipine, a selective dihydropyridine calcium channel blocker. This compound exhibits significant vasodilatory activity and is commonly utilized in the management of hypertension and angina. As a stable isotope, Levamlodipine-d4 is a valuable tool for pharmacokinetic studies and related research applications. -
Stable Isotope
Menthol-d2 is a deuterated derivative of menthol, serving as a stable isotope. It acts as an analgesic and modulates the TRPM8 ion channel, which is responsible for sensing cold temperatures. By regulating TRPM8, Menthol-d2 exerts analgesic and anti-irritation effects. Additionally, it stimulates cold receptors, inducing a cooling sensation through the inhibition of Ca++ currents in neuronal cell membranes, making it valuable for research in pain relief and sensory modulation. -
Stable Isotope
Amlodipine-1,1,2,2-d4 maleate is a deuterium-labeled derivative of Amlodipine, a dihydropyridine calcium channel blocker. Its primary mechanism involves the inhibition of voltage-dependent L-type calcium channels, which reduces calcium influx. This reagent is valuable for studies related to hypertension and cancer research, offering insights into calcium signaling pathways and their implications in various pathological conditions. -
Stable Isotope
Diltiazem-d5 hydrochloride is a deuterated isotopic form of Diltiazem, a calcium channel blocker that inhibits L-type calcium channels. Its primary mechanism involves modulation of calcium ion influx, leading to reduced myocardial contractility and vasodilation. This stable isotope is valuable for pharmacokinetic studies, metabolic pathway analysis, and isotopic labeling techniques in chemical research and drug development. -
Stable Isotope
Farnesyl pyrophosphate-d6 is a deuterium-labeled stable isotope derivative of farnesyl pyrophosphate, an important metabolic intermediate in the mevalonate pathway. It acts as an agonist for TRP channel TRPM2, facilitating calcium influx and promoting cell death. Farnesyl pyrophosphate plays a crucial role in cholesterol and ubiquinone synthesis, as well as in protein farnesylation and geranylgeranyl pyrophosphate synthesis. This reagent is utilized in research exploring cerebral ischemia, neurodegenerative diseases, pancreatic cancer, inflammation, and autoimmune disorders. -
Stable Isotope
Diltiazem-d4 is a deuterated form of Diltiazem, which acts as a selective L-type calcium channel blocker. It exhibits significant antihypertensive and antiarrhythmic properties, making it useful in the study of cardiac arrhythmias, hypertension, and angina pectoris. This stable isotope is ideal for research applications requiring isotopic tracing and elucidation of pharmacokinetic pathways involved in calcium channel modulation. -
Stable Isotope
Ranolazine-d8 is a deuterated form of Ranolazine, which primarily targets the late phase of inward sodium current (INa) and potassium current (IKr) with IC50 values of 6 μM and 12 μM, respectively. This compound functions as an anti-anginal agent, alleviating symptoms without influencing heart rate or blood pressure. Additionally, Ranolazine acts as a partial fatty acid oxidation inhibitor, making it valuable for research related to cardiac ischemia and metabolic modulation in heart diseases. -
Stable Isotope
Verapamil-d3 is a deuterium-labeled form of Verapamil, a calcium channel blocker that serves as a potent, orally active first-generation inhibitor of P-glycoprotein (P-gp) and CYP3A4. This stable isotope variant is utilized in pharmacokinetic studies and metabolic research, aiding in the investigation of cardiovascular diseases such as hypertension, arrhythmias, and angina. Verapamil-d3's unique properties make it an invaluable tool for studying drug interactions and bioavailability in various biological systems. -
Stable Isotope
1-Octanol-d2-1 is a deuterated form of 1-Octanol, serving as a stable isotope for various research applications. As a saturated fatty alcohol, 1-Octanol acts as an inhibitor of T-type calcium channels with an IC50 value of 4 μM for native T-currents, making it valuable for studies in neurobiology and pharmacology. Additionally, its characteristics as a biofuel with diesel-like properties position it for investigation in energy research and sustainable technologies. -
Stable Isotope
Norverapamil-d6 hydrochloride is a stable isotope-labeled version of Norverapamil, an N-demethylated metabolite of Verapamil. This compound acts as a blocker of L-type calcium channels and inhibits P-glycoprotein (P-gp) function. It is primarily utilized in pharmacokinetic studies, drug metabolism research, and for tracing metabolic pathways in biological systems. -
Stable Isotope
Diltiazem-d6 hydrochloride is a deuterium-labeled derivative of Diltiazem, functioning as a calcium antagonist that inhibits Ca2+ influx. This stable isotope is primarily utilized in research applications involving pharmacokinetics, metabolic studies, and the optimization of drug formulations. Its deuterated form enhances analytical sensitivity and specificity in various biochemical analyses. -
Stable Isotope
Teludipine-d6 is a deuterium-labeled analog of Teludipine hydrochloride, a potent lipophilic calcium channel blocker. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the metabolic pathways of Teludipine without altering its pharmacological properties. It is well-suited for investigations requiring precise quantification of drug concentrations in biological systems. -
Stable Isotope
O-Desmethyl carvedilol-d5 is a deuterium-labeled derivative of O-Desmethylcarvedilol, a potent active metabolite of the non-selective β-adrenergic receptor antagonist Carvedilol. This compound exhibits inhibitory effects on store-overload-induced calcium release in HEK293 cells expressing the RyR2 R4496C mutation, with an IC50 of 7.62 μM. Additionally, O-Desmethyl carvedilol-d5 contributes to cardiovascular research by attenuating heart rate increases and stabilizing diastolic blood pressure in response to Isoproterenol in conscious rabbit models, demonstrating ED50 values of 32 and 5 μg/kg, respectively. -
Stable Isotope
Taurolithocholic Acid-d5 sodium is a deuterium-labeled derivative of Taurolithocholic acid, serving as a stable isotope for analytical studies. This compound exhibits potent cholestatic activity and functions as a significant Ca2+ agonist, making it valuable for research in liver function and bile acid metabolism. Taurolithocholic Acid-d5 sodium can be utilized in pharmacokinetic studies and tracer experiments to elucidate the biological pathways of bile acids and their physiological effects. -
Stable Isotope
DSPC-d9 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d9) is a deuterium-labeled form of DSPC, a cylindrical-shaped phospholipid. This reagent is primarily utilized in the preparation of liposomes and serves as a critical component in lipid nanoparticle (LNP) formulations. Its stable isotope labeling enables enhanced tracking and characterization of lipid interactions and dynamics in biological research and drug delivery applications. -
Stable Isotope
DSPC-d13, a deuterated form of 1,2-Distearoyl-sn-glycero-3-phosphorylcholine, serves as a stable isotope for various biological studies. This cylindrical-shaped lipid is integral for the synthesis of liposomes and functions as a key component in lipid nanoparticle (LNP) systems. Its unique labeling with deuterium facilitates advanced research applications in drug delivery and lipid metabolism studies, enabling enhanced tracking and analysis in complex biological environments. -
Stable Isotope
DSPC-d79 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d79) is a deuterium-labeled analog of DSPC, a cylindrical-shaped phospholipid. This compound is crucial for the synthesis of liposomes and serves as a key lipid component in lipid nanoparticle (LNP) formulations. DSPC-d79 can be utilized in studies involving drug delivery systems, membrane biology, and biophysical characterization of lipid structures, enabling enhanced tracking and analysis in various biomedical research applications. -
Stable Isotope
1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol-d70 sodium is a deuterium-labeled form of 1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol. This stable isotope serves as a vital component in the formulation of liposomes, enhancing the precision of drug delivery systems. Its application extends to various biochemical and biological research, facilitating the study of lipid dynamics and membrane interactions in a wide range of experimental settings. -
Stable Isotope
1-Palmitoyl-2-oleoyl-sn-glycero-3-PC-13C16 is a stable isotope-labeled phospholipid, specifically 13C enriched 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC). It serves as a crucial component in the synthesis of liposomes and is utilized for in-depth investigations of lipid bilayer properties and behavior. This reagent supports research in membrane biology and lipid metabolism, aiding in the study of cellular processes and membrane interactions. -
Stable Isotope
DSPC-d74 (1,2-Distearoyl-sn-glycero-3-phosphorylcholine-d74) is a deuterium-labeled derivative of DSPC, a cylindrical-shaped phospholipid. This reagent plays a crucial role in the synthesis of liposomes and is a key component of lipid nanoparticle (LNP) formulations. DSPC-d74 can be utilized in various biological studies, including membrane biology and drug delivery research, due to its unique isotopic labeling which allows for enhanced tracking and analysis in mass spectrometry applications. -
Stable Isotope
Glyceryl monostearate-d5 is a deuterium-labeled version of glyceryl monostearate, a lipidic monoglyceride consisting of a single fatty tail. This stable isotope serves as a valuable tracer in metabolic studies and lipid research, aiding in the synthesis of nanoliposomes for drug delivery applications. Glyceryl monostearate-d5 can be utilized to investigate lipid metabolism and cellular interactions, providing insights into drug formulation and delivery mechanisms. -
Stable Isotope
Atreleuton-d4 is a deuterium-labeled derivative of Atreleuton, which acts as a stable isotope. This compound is primarily utilized in pharmacokinetic studies and metabolic research to improve the understanding of drug absorption, distribution, metabolism, and excretion (ADME) processes. It serves as a valuable tool for scientists investigating the biological activity of Atreleuton in various therapeutic applications. -
Stable Isotope
Lomitapide-d4 is a deuterium-labeled derivative of Lomitapide, a potent inhibitor of microsomal triglyceride transfer protein (MTP). With an IC50 value of 8 nM, Lomitapide effectively disrupts the transport of triglycerides, making it an important tool for studying lipid metabolism and related disorders. This stable isotope variant is valuable for research applications that require the tracing of molecular pathways involving MTP modulation. -
Isotope-Labeled Compounds
Finerenone-d3 is a deuterium-labeled form of finerenone, a selective, orally active nonsteroidal mineralocorticoid receptor (MR) antagonist with an IC50 of 18 nM. This compound exhibits remarkable selectivity against glucocorticoid, androgen, and progesterone receptors, with over 500-fold selectivity. Finerenone-d3 is valuable for studying cardiorenal diseases, including type 2 diabetes mellitus and chronic kidney disease, enabling detailed metabolic and pharmacokinetic investigations in research settings. -
Stable Isotope
Ethylmalonic acid-d3 is a stable isotope-labeled form of ethylmalonic acid. This short-chain organic dicarboxylic acid plays a significant role in inducing mitochondrial permeability transition in conjunction with calcium ions, inhibiting mitochondrial creatine kinase, and disrupting mitochondrial energy metabolism. Ethylmalonic acid-d3 is utilized in the research of short-chain acyl-CoA dehydrogenase deficiency and other genetic metabolic disorders associated with ethylmalonic acid accumulation. -
Stable Isotope
MPP+-d3 iodide is a deuterium-labeled derivative of MPP+ (iodide), primarily targeting dopaminergic neurons. This compound is known for inducing Parkinson’s disease-like symptoms in animal models by selectively damaging dopaminergic neurons in the substantia nigra, primarily through its action on mitochondrial complex I within the respiratory chain. Additionally, MPP+ iodide serves as a high-affinity substrate for the serotonin transporter (SERT), making it useful for studies examining the neurotoxic mechanisms and transport processes in neurodegenerative disease research. -
Stable Isotope
1-Hexanol-d13 is a deuterium-labeled variant of 1-Hexanol, a primary alcohol known for its application as a surfactant in various industrial processes to improve interfacial properties. This compound is also observed to uncouple mitochondrial respiration through a non-protonophoric mechanism, facilitating studies related to energy metabolism. Its stable isotope labeling makes it a valuable tool for tracer studies in biological research. -
Stable Isotope
1-Hexanol-d11 is a deuterated form of 1-hexanol, a primary alcohol known for its surfactant properties. This stable isotope serves as a valuable tool in studies involving the characterization of interfacial properties in various industrial applications. Additionally, 1-Hexanol is recognized for its ability to uncouple mitochondrial respiration through a non-protonophoric mechanism, making it relevant in metabolic and bioenergetics research. -
Stable Isotope
Ethylmalonic acid-d5 is a deuterated form of ethylmalonic acid, serving as a stable isotope for research applications. This short-chain organic dicarboxylic acid is known to synergistically induce mitochondrial permeability transition in conjunction with Ca2+, inhibit mitochondrial creatine kinase (Mi-CK), and disrupt mitochondrial energy metabolism. Ethylmalonic acid-d5 is valuable in studying disorders such as short-chain acyl-CoA dehydrogenase deficiency (SCADD) and other genetic metabolic diseases associated with the accumulation of ethylmalonic acid. -
Stable Isotope
1-Hexanol-d5 is a deuterated form of 1-Hexanol, a primary alcohol recognized for its role as a surfactant in industrial applications, enhancing interfacial properties. This compound is known to uncouple mitochondrial respiration through a non-protonophoric mechanism, making it useful in studies related to cellular energy metabolism and mitochondrial function. The stable isotope labeling facilitates precise tracing in biochemical research and analytical applications. -
Stable Isotope
1-Hexanol-d2 is a deuterated form of 1-Hexanol, serving as a stable isotope for various analytical applications. As a primary alcohol and surfactant, it is utilized in industrial processes to improve interfacial properties. Additionally, 1-Hexanol has been shown to uncouple mitochondrial respiration through a non-protonophoric mechanism, making it valuable for research in bioenergetics and metabolic regulation. -
Stable Isotope
1-Hexanol-d3 is a stable isotope-labeled form of 1-Hexanol, which is a primary alcohol and surfactant. This compound has significant applications in industrial processes to improve interfacial properties. Additionally, 1-Hexanol-d3 is known to uncouple mitochondrial respiration through a non-protonophoric mechanism, making it valuable in metabolic studies and respiratory function research. -
Stable Isotope
o-Phenanthroline-d8 is a deuterium-labeled derivative of o-Phenanthroline, a potent metal chelator. This compound effectively prevents the induction of chromosomal aberrations in streptozotocin-treated cells and forms a red chelate with Fe2+, exhibiting a maximum absorption at 510 nm. Additionally, o-Phenanthroline functions as an inhibitor of matrix metalloproteinases (MMPs), making it valuable in various research applications related to cancer biology and oxidative stress studies. -
Stable Isotope
Hydralazine-d4 hydrochloride is a deuterated form of Hydralazine hydrochloride, known for its action as a direct-acting vasodilator. It primarily targets vascular smooth muscle, leading to relaxation and a reduction in blood pressure, making it valuable in antihypertensive research. This stable isotope is particularly useful for pharmacokinetic studies and metabolic profiling in drug development and cardiovascular research applications. -
Stable Isotope
Butibufen-d5 is a deuterated analog of Butibufen, a non-steroidal compound known for its analgesic and antipyretic effects. This stable isotope can be utilized in pharmacokinetic studies and metabolic research to trace the compound's behavior in biological systems. It is particularly valuable in inflammation research, providing insights into the mechanisms of action and efficacy of non-steroidal anti-inflammatory drugs. -
WNK Kinase Inhibitor
WNK-IN-11-d3 is a selective and potent inhibitor of WNK kinases, designed for oral administration. This compound plays a crucial role in modulating cardiovascular homeostasis and serves as a valuable tool in studying cardiovascular signaling pathways and related conditions. Its unique mechanism of action makes it a significant reagent for research applications targeting WNK kinase-related processes. -
Stable Isotope
11-Beta-hydroxyandrostenedione-d7 is a deuterium-labeled form of 11-Beta-hydroxyandrostenedione, a steroid primarily produced in the adrenal glands. This compound serves as an inhibitor of the 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes, making it valuable for studies involving steroid metabolism and hormone regulation. Its stable isotope labeling enables precise measurements in biological samples, supporting research on endocrine function and related disorders. -
Stable Isotope
11-Beta-hydroxyandrostenedione-d4 is the deuterium-labeled form of 11-beta-hydroxyandrostenedione, which is a steroid primarily derived from the adrenal gland. This compound acts as an inhibitor of 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes, playing a crucial role in steroid metabolism. It is particularly useful in studies related to adrenal steroidogenesis and hormone regulation, enabling accurate tracking of metabolic pathways in various biological research applications. -
Stable Isotope
Alpha-Estradiol-d2 is a deuterium-labeled variant of Alpha-Estradiol, exhibiting stable isotope properties. As a weak estrogen and a 5α-reductase inhibitor, it is primarily utilized in the study of androgenic alopecia and related treatments. This reagent is valuable for research applications involving hormone metabolism, endocrine signaling, and the exploration of therapeutic strategies targeting hair loss. -
Stable Isotope
Finasteride-d9 is a deuterium-labeled derivative of Finasteride, a potent competitive inhibitor of 5α-reductase, exhibiting an IC50 of 4.2 nM for the type II isoform. This compound demonstrates significantly greater affinity for type II 5α-reductase, being approximately 100 times more selective than for type I. Finasteride-d9 is valuable in research applications focused on benign prostatic hyperplasia (BPH) and androgenic alopecia, facilitating studies on the pharmacokinetics and metabolism of its parent compound. -
Stable Isotope
Terbuthylazine-d5 is a deuterium-labeled derivative of terbuthylazine, functioning primarily as an inhibitor of acetolactate synthase (ALS). As a selective herbicide, it exhibits significant biological activity in disrupting the growth of certain plants by interfering with the synthesis of branched-chain amino acids. This stable isotope compound is valuable for research applications in agronomy and environmental studies, particularly in the analysis of herbicide metabolism and distribution in biological systems. -
Stable Isotope
Nicosulfuron-d6 is a deuterium-labeled analog of Nicosulfuron, a selective herbicide from the sulfonylurea class. This compound exhibits inhibition of the acetolactate synthase (ALS) enzyme, which plays a crucial role in amino acid biosynthesis. Nicosulfuron-d6 is primarily utilized in research applications demanding stable isotopic labeling, facilitating the study of herbicide mechanisms and their interactions in agricultural settings. -
Stable Isotope
Terbuthylazine-d9 is a deuterium-labeled derivative of Terbuthylazine, functioning primarily as an inhibitor of acetolactate synthase (ALS). This stable isotope is utilized in biochemical research to study the mechanisms of herbicide action and plant physiology. Its specific activity as a selective herbicide makes it valuable for investigating herbicide resistance and environmental fate in agricultural studies. -
Stable Isotope
2-Furoic acid-d3 is a deuterated stable isotope of 2-Furoic acid, an organic compound with the formula C5H4O3. This compound is recognized for its hypolipidemic effects, effectively reducing serum cholesterol and triglyceride levels in animal models. It is used in metabolic studies and tracer experiments to understand lipid metabolism and related biological pathways. -
Stable Isotope
L-Palmitoylcarnitine-d3 hydrochloride is the deuterium-labeled form of L-Palmitoylcarnitine hydrochloride, which serves as a stable isotope in research applications. This long-chain acylcarnitine plays a crucial role in fatty acid metabolism and is known to accumulate in the sarcolemma, disrupting membrane lipid composition during ischemic conditions. Additionally, L-Palmitoylcarnitine hydrochloride inhibits KATP channel activity via interaction with the Kir6.2 subunit, providing valuable insights for studies on cardiac health and metabolic disorders.
