ITF5924 is a potent and highly selective inhibitor of HDAC6, exhibiting an IC50 of 7.7 nM. This compound demonstrates over 104-fold selectivity for HDAC6 compared to other HDAC subtypes. The unique difluoromethyl-1,3,4-oxadiazole (DFMO) moiety allows ITF5924 to function as a slow-binding substrate analog, undergoing an enzyme-catalyzed ring-opening reaction that forms a stable and long-lasting enzyme-inhibitor complex. ITF5924 is valuable for studies exploring the role of HDAC6 in various cellular processes and disease states, making it an essential tool for epigenetic research.
ITF5924 is a potent and highly selective inhibitor of HDAC6, exhibiting an IC50 of 7.7 nM. This compound demonstrates over 104-fold selectivity for HDAC6 compared to other HDAC subtypes. The unique difluoromethyl-1,3,4-oxadiazole (DFMO) moiety allows ITF5924 to function as a slow-binding substrate analog, undergoing an enzyme-catalyzed ring-opening reaction that forms a stable and long-lasting enzyme-inhibitor complex. ITF5924 is valuable for studies exploring the role of HDAC6 in various cellular processes and disease states, making it an essential tool for epigenetic research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
