Iturin A-2 is a cyclic lipopeptide antibiotic derived from Bacillus subtilis, demonstrating potent inhibitory activity against the plant pathogenic fungus Penicillium expansum with a minimal inhibitory concentration (MIC) of 8 µg/disk. This compound exhibits cytotoxic effects on various cancer cell lines, including MCF-7, BT474, and HeLa, with IC50 values of 66.81, 95.04, and 77.5 µg/mL, respectively. Additionally, Iturin A-2 effectively reduces lesion areas in southern corn leaf blight caused by Bipolaris maydis in greenhouse studies and decreases disease incidence in field studies at higher concentrations. At 12.5 µg/mL, Iturin A-2 inhibits cell division in isolated fertilized starfish eggs without affecting nuclear division.
Iturin A-2 is a cyclic lipopeptide antibiotic derived from Bacillus subtilis, demonstrating potent inhibitory activity against the plant pathogenic fungus Penicillium expansum with a minimal inhibitory concentration (MIC) of 8 µg/disk. This compound exhibits cytotoxic effects on various cancer cell lines, including MCF-7, BT474, and HeLa, with IC50 values of 66.81, 95.04, and 77.5 µg/mL, respectively. Additionally, Iturin A-2 effectively reduces lesion areas in southern corn leaf blight caused by Bipolaris maydis in greenhouse studies and decreases disease incidence in field studies at higher concentrations. At 12.5 µg/mL, Iturin A-2 inhibits cell division in isolated fertilized starfish eggs without affecting nuclear division.
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