Catalog No.: A15899

γ-secretase inhibitor


L-685458 Chemical Structure

CAS NO. 292632-98-5

L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.

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Biological Activity

L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
17 nM(Ki)
In vitro DMSO 86 mg/mL (127.81 mM)
Water Insoluble
Ethanol Warmed: 5 mg/mL (7.43 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.86 mL 74.31 mL 148.62 mL
0.5 mM 2.97 mL 14.86 mL 29.72 mL
1 mM 1.49 mL 7.43 mL 14.86 mL
5 mM 0.3 mL 1.49 mL 2.97 mL

*The above data is based on the productmolecular weight 672.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15899
Actions Inhibitor
CAS No. 292632-98-5
Formula C39H52N4O6
M. Wt 672.85
Purity >98%
Synonyms L685458, L 685458, L685,458
SMILES O=C(OC(C)(C)C)N[[email protected]]([[email protected]](O)C[[email protected]@H](CC1=CC=CC=C1)C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CC2=CC=CC=C2)C(N)=O)=O)=O)CC3=CC=CC=C3

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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