Catalog No.: A15899
γ-secretase inhibitor
L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
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L-685458 1mg
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L-685458 2mg
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L-685458 5mg
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Biological Activity
Discription L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
Target Value
Product Information
Catalog Num A15899
Formula C39H52N4O6
Molecular Weight 672.85
CAS Number 292632-98-5
SMILES O=C(OC(C)(C)C)N[C@H]([C@H](O)C[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC2=CC=CC=C2)C(N)=O)=O)=O)CC3=CC=CC=C3
Synonyms L685458, L 685458, L685,458

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

In vitro DMSO 86 mg/mL (127.81 mM)
Water Insoluble
Ethanol Warmed: 5 mg/mL (7.43 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.86 mL 74.31 mL 148.62 mL
0.5 mM 2.97 mL 14.86 mL 29.72 mL
1 mM 1.49 mL 7.43 mL 14.86 mL
5 mM 0.3 mL 1.49 mL 2.97 mL
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