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γ-secretase inhibitor

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Catalog No. A15899

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
L-685458 1mg A15899-1
L-685458 2mg A15899-2
L-685458 5mg A15899-5

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.


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Chemical Information

Catalog Num A15899
Actions Inhibitor
M. Wt 672.85
Formula C39H52N4O6
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 292632-98-5
Synonyms L685458, L 685458, L685,458
SMILES O=C(OC(C)(C)C)N[[email protected]]([[email protected]](O)C[[email protected]@H](CC1=CC=CC=C1)C(N[[email protected]@H](CC(C)C)C(N[[email protected]@H](CC2=CC=CC=C2)C(N)=O)=O)=O)CC3=CC=CC=C3

Biological Activity

L-685458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM.
17 nM(Ki)

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.86 mL 74.31 mL 148.62mL
0.5 mM 2.97 mL 14.86 mL 29.72 mL
1 mM 1.49 mL 7.43 mL 14.86 mL
5 mM 0.3 mL 1.49 mL 2.97 mL

*The above data is based on the productmolecular weight 672.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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