LCZ696 (Valsartan)

Catalog No.: A14206

angiotensin receptor-neprilysin inhibitor

LCZ696 (Valsartan)

LCZ696 (Valsartan) Chemical Structure

CAS NO. 936623-90-4

LCZ696 is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure.

Availability: In stock

Package Price Qty
5 mg
$65.00
10 mg
$90.00
25 mg
$180.00
10mM * 1mL in DMSO
$100.00
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Biological Activity

LCZ696 is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure.
Targets
RAAS
In vitro DMSO Warmed: 26 mg/mL (28.38 mM)
Water Warmed: 88 mg/mL (96.07 mM)
Ethanol Warmed: 8 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 10.92 mL 54.59 mL 109.17 mL
0.5 mM 2.18 mL 10.92 mL 21.83 mL
1 mM 1.09 mL 5.46 mL 10.92 mL
5 mM 0.22 mL 1.09 mL 2.18 mL

*The above data is based on the productmolecular weight 915.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A14206
Actions Inhibitor
CAS No. 936623-90-4
Formula C24H29N5O3.C24H29NO5.5/2H2O.3Na
M. Wt 915.98
Purity >98%
Synonyms LCZ 696, LCZ-696
SMILES CCCCC(=O)N(CC1=CC=C(C=C1)C2=CC=CC=C2C3=NNN=N3)[[email protected]@H](C(C)C)C(=O)O.CCOC(=O)[[email protected]](C)C[[email protected]@H](CC1=CC=C(C=C1)C2=CC=CC=C2)NC(=O)CCC(=O)O.O.O.O.[Na+].[Na+].[Na+]
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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