Neprilysin

Racecadotril is a potent enkephalinase inhibitor which exhibits selective antisecretory activity.

AHU-377 is an inhibitor of neprilysin with IC50 value of 5nM.

LHW090-A7 is an inhibitor of neutral endopeptidase (NEP), an enzyme responsible for the metabolic inactivation of enkephalins.

LCZ696 is an orally bioavailable, dual-acting angiotensin receptor-neprilysin inhibitor (ARNi) for hypertension and heart failure.

Phosphoramidon Disodium Salt is a metalloendopeptidase inhibitor.

Candoxatril is a neutral endopeptidase (NEP) inhibitor.

Sacubitrilat is an active neprilysin (NEP) inhibitor.

Sch-42495 racemate is the racemate of Sch-42495. Sch-42495 is a novel neutral metalloendopeptidase (NEP) inhibitor. Sch-42495 is the orally active ethylester prodrug of SCH 42354.

Opiorphin, an opioid peptide, is a potent enkephalin-inactivating zinc ectopeptidases in human inhibitor. Opiorphin inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-endopeptidase, hNEP (EC 3.4.24.11) with an IC50 value of 11 μM, and human ecto-aminopeptidase, hAP-N (EC 3.4.11.2). Opiorphin displays potent analgesic activity by activating endogenous opioid-dependent transmission.