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- Sayuri Nitta, .et al. Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients, Scientific Reports, 2019, 9: 5722 PMID: 30952914
- Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467
- Sayuri Nitta, .et al. Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents, Sci Rep, 2016, 6: 34652 PMID: 27703205
Biological Activity
Ledipasvir is an inhibitor of the hepatitis C virus HCV NS5A protein
Targets
| HCV | ||||
| In vitro | DMSO | 93 mg/mL (104.61 mM) | |
| Water | Insoluble | ||
| Ethanol | 93 mg/mL (104.61 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 11.25 mL | 56.24 mL | 112.49 mL |
| 0.5 mM | 2.25 mL | 11.25 mL | 22.5 mL |
| 1 mM | 1.12 mL | 5.62 mL | 11.25 mL |
| 5 mM | 0.22 mL | 1.12 mL | 2.25 mL |
*The above data is based on the productmolecular weight 889. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13155 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1256388-51-8 |
| Formula | C49H54F2N8O6 |
| M. Wt | 889 |
| Purity | >98% |
| Synonyms | GS5885, GS-5885 |
| SMILES | CC(C)[[email protected]@H](C(=O)N1CC2(CC2)C[[email protected]]1C3=NC=C(N3)C4=CC5=C(C=C4)C6=C(C5(F)F)C=C(C=C6)C7=CC8=C(C=C7)N=C(N8)[[email protected]@H]9[[email protected]]1CC[[email protected]](C1)N9C(=O)[[email protected]](C(C)C)NC(=O)OC)NC(=O)OC |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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