Lolamicin is an orally effective antibiotic that specifically targets the Gram-negative bacterial lipoprotein transport system, particularly the LolCDE complex. By competitively binding to lipoprotein binding sites, it inhibits the transmembrane transport of outer membrane lipoproteins, compromising the integrity of the bacterial outer membrane and resulting in cell death. Lolamicin demonstrates significant bactericidal and antibacterial activity against multidrug-resistant Enterobacteriaceae pathogens, including Escherichia coli and Klebsiella pneumoniae. This reagent is valuable for studying infections such as acute pneumonia and sepsis caused by Gram-negative bacteria.
Lolamicin is an orally effective antibiotic that specifically targets the Gram-negative bacterial lipoprotein transport system, particularly the LolCDE complex. By competitively binding to lipoprotein binding sites, it inhibits the transmembrane transport of outer membrane lipoproteins, compromising the integrity of the bacterial outer membrane and resulting in cell death. Lolamicin demonstrates significant bactericidal and antibacterial activity against multidrug-resistant Enterobacteriaceae pathogens, including Escherichia coli and Klebsiella pneumoniae. This reagent is valuable for studying infections such as acute pneumonia and sepsis caused by Gram-negative bacteria.
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