Lopinavir (ABT-378)

Catalog No.: A10537

HIV Protease inhibitor

Lopinavir (ABT-378)

Lopinavir (ABT-378) Chemical Structure

CAS NO. 192725-17-0

Lopinavir is an inhibitor of the HIV protease.

Availability: In stock

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10 mg
100 mg
200 mg
10mM * 1mL in DMSO
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Biological Activity

Lopinavir is an inhibitor of the HIV protease.
HIV protease (Cell-free assay)
1.3 pM(Ki)
In vitro (25°C) DMSO 116 mg/mL (184.48 mM)
Water Insoluble
Ethanol 116 mg/mL (184.48 mM)
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 15.9 mL 79.52 mL 159.03 mL
0.5 mM 3.18 mL 15.9 mL 31.81 mL
1 mM 1.59 mL 7.95 mL 15.9 mL
5 mM 0.32 mL 1.59 mL 3.18 mL

*The above data is based on the productmolecular weight 628.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10537
Actions Inhibitor
CAS No. 192725-17-0
Formula C37H48N4O5
M. Wt 628.8
Purity >98%
Synonyms ABT-378
SMILES CC1=C(C(=CC=C1)C)OCC(=O)N[[email protected]@H](CC2=CC=CC=C2)[[email protected]](C[[email protected]](CC3=CC=CC=C3)NC(=O)[[email protected]](C(C)C)N4CCCNC4=O)O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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