Loratadine-d4-1 is a deuterium-labeled derivative of Loratadine, a selective inverse agonist of peripheral H1-histamine receptors. With an IC50 value exceeding 32 μM, Loratadine exhibits significant biological activity, including anti-dengue virus (DENV) effects and the inhibition of immunologic release of inflammatory mediators. This stable isotope reagent is valuable for mechanistic studies, pharmacokinetic evaluations, and research applications in allergy and inflammatory response investigations.
Loratadine-d4-1 is a deuterium-labeled derivative of Loratadine, a selective inverse agonist of peripheral H1-histamine receptors. With an IC50 value exceeding 32 μM, Loratadine exhibits significant biological activity, including anti-dengue virus (DENV) effects and the inhibition of immunologic release of inflammatory mediators. This stable isotope reagent is valuable for mechanistic studies, pharmacokinetic evaluations, and research applications in allergy and inflammatory response investigations.
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