LY294002

Catalog No.: A10547
PI3K Inhibitor
LY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor.
Grouped product items
Size Price Stock Qty
5mg
$25.00
In stock
10mg
$40.00
In stock
25mg
$60.00
In stock
50mg
$65.00
In stock
100mg
$85.00
In stock
200mg
$120.00
In stock
500mg
$250.00
In stock
10mM * 1mL in DMSO
$45.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

Loading distributor info...

Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Adooq's LY294002 has been cited by 11 publications
  • Yinhua Ni, .et al. , J Agric Food Chem, 2024, Jul 31;72(30):16708-16725 PMID: 39016108
  • Yinhua Ni, .et al. , J Nutr Biochem, 2024, Mar:125:109569 PMID: 38185346
  • Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418
  • Nahla E. El-Ashmawy, .et al. , Clin Phytosci, 2022, 8: 20
  • Ming-Chun Hung, .et al. , Cell Biosci, 2022, 12: 122 PMID: 35918763
  • Chien-Feng Li, .et al. , Cell Oncol (Dordr), 2021, Aug 2 PMID: 34339014
  • Hiroharu Sakai, .et al. , Exp Ther Med, 2021, March 5 PMID: 33747195
  • Cheng Zhou, .et al. , Cell Death Dis, 2021, Mar 3;12(3):231 PMID: 33658491
  • Daniel Limonta, .et al. , J Infect Dis, 2019, 2019 PMID: 30799482
  • Lv H, .et al. , J Cell Physiol, 2018, Oct 26 PMID: 30362547
  • Hui Liang, .et al. , Sci Rep, 2017, 7: 40361 PMID: 28098170
Biological Activity
DescriptionLY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor.
Targets
TargetValue
Cell Research
Cell LineTypeValueDescriptionReferences
Product Information
Catalog NumA10547
FormulaC19H17NO3
Molecular Weight307.3
CAS Number154447-36-6
SMILESC1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO31 mg/mL (100.86 mM)
WaterInsoluble
Ethanol18 mg/mL (58.56 mM)
In vivo5% DMSO+ 40%PEG 300+5% Tween 80+50%ddH2O2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM32.54 mL162.71 mL325.41 mL
0.5 mM6.51 mL32.54 mL65.08 mL
1 mM3.25 mL16.27 mL32.54 mL
5 mM0.65 mL3.25 mL6.51 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

    Concentration

    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

    V1

    C2

    V2

Frequently Asked Questions
What is the mechanism of action of LY294002?
LY294002 inhibits PI3K by competing with ATP at the catalytic site of the p110 subunit. This prevents the phosphorylation of phosphatidylinositol 4,5-bisphosphate (PIP2) into phosphatidylinositol 3,4,5-trisphosphate (PIP3), thereby blocking AKT pathway activation.
What is the IC50 of LY294002?
The reported IC50 value of LY294002 against PI3K is approximately 1–10 μM, depending on assay conditions and isoform specificity.
What is LY294002 used for?
LY294002 is commonly used in cell biology and cancer research to study PI3K/AKT signaling, apoptosis, autophagy, and cell cycle regulation.
How does LY294002 compare to Wortmannin?
Compared to Wortmannin, LY294002 is a reversible PI3K inhibitor with lower potency but greater chemical stability and ease of handling in laboratory applications.