LY294002

Catalog No.: A10547

PI3K Inhibitor

LY294002

LY294002 Chemical Structure

CAS NO. 154447-36-6

LY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor.

Availability: In stock

Package Price Qty
10 mg
$50.00
25 mg
$60.00
50 mg
$70.00
200 mg
$130.00
10mM * 1mL in DMSO
$50.00
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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Daniel Limonta, .et al. Fibroblast growth factor 2 enhances Zika virus infection in human fetal brain, J Infect Dis, 2019, 2019 PMID: 30799482
  • Lv H, .et al. CXCL8 gene silencing promotes neuroglial cells activation while inhibiting neuroinflammation through the PI3K/Akt/NF-κB-signaling pathway in mice with ischemic stroke, J Cell Physiol, 2018, Oct 26 PMID: 30362547
  • Hui Liang, .et al. Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells, Sci Rep, 2017, 7: 40361 PMID: 28098170

Biological Activity

LY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor.
Targets
p110α (Cell-free assay) p110δ (Cell-free assay) p110β (Cell-free assay)
0.5 μM0.57 μM0.97 μM
In vitro (25°C) DMSO 36 mg/mL (117.13 mM)
Water <1 mg/mL (<1 mM)
Ethanol 21 mg/mL (68.32 mM)
In vivo 1% DMSO/30% polyethylene glycol/1% Tween 80 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 32.54 mL 162.71 mL 325.41 mL
0.5 mM 6.51 mL 32.54 mL 65.08 mL
1 mM 3.25 mL 16.27 mL 32.54 mL
5 mM 0.65 mL 3.25 mL 6.51 mL

*The above data is based on the productmolecular weight 307.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10547
Actions Inhibitor
M. Wt 307.3
Formula C19H17NO3
Solubility DMSO>36mg/mL Water<1mg/mL Ethanol>21mg/mL
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 154447-36-6
SMILES C1COCCN1C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4

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