TOPK

OTS964 is a selective inhibitor of T-cell orientation protein kinase (TOPK), demonstrating a high affinity with an IC50 of 28 nM. Additionally, OTS964 effectively inhibits cyclin-dependent kinase 11 (CDK11), with a binding affinity (Kd) of 40 nM for CDK11B. This compound is utilized in research exploring cancer therapeutic strategies and cell cycle regulation.

TOPK-p38/JNK-IN-1 is an orally active inhibitor targeting the TOPK-p38/JNK signaling pathway, exhibiting an IC50 value of 2.14 µM for nitric oxide production. This compound demonstrates significant anti-inflammatory activity by inhibiting the phosphorylation of downstream proteins while preventing degradation of TOPK. Research applications include studies on inflammatory processes and cellular signaling mechanisms in various disease models.

OTS964 is a potent TOPK inhibitor with an IC50 value of 28 nM.

Cephradine monohydrate (Cefradine monohydrate) is a first generation cephalosporin, which is active against a wide range of Gram positive and Gram-negative bacteria.

OTS514, a thieno[2,3-c]quinolone compound, is a highly potent TOPK inhibitor with an IC50 value of 2.6 nM. The compound can inhibit TOPK kinase activity.

HI-TOPK-032 is a potent and selective TOPK inhibitor. In vitro, HI-TOPK-032 strongly suppressed TOPK kinase activity but had little effect on extracellular signal-regulated kinase 1 (ERK1), c-jun-NH2-kinase 1, or p38 kinase activities.

SKLB-C05 is a highly selective, orally active inhibitor of the T-Lymphokine-Activated Killer Cell-originated Protein Kinase (TOPK), exhibiting an IC50 of 0.5 nM. This compound has demonstrated the ability to induce apoptosis, downregulate c-Myc, and activate p53 while disrupting FAK/Src-mediated migratory signaling. Additionally, SKLB-C05 interferes with cell mitosis and displays significant anticancer activity specifically against TOPK-positive colorectal cancer, making it a valuable tool for cancer research.