Merulidial is an antibiotic and cytotoxic agent characterized by its sesquiterpene dialdehyde structure. It effectively inhibits the germination of spores and hyphal growth in the wood-rotting basidiomycete Heterobasidion annosum and the saprophytic mold Cladosporium cucumerinum. Additionally, Merulidial demonstrates antibacterial and algicidal properties, along with the ability to inhibit DNA synthesis in ECA cells. Notably, it exhibits potent anticancer activity, with IC50 values of 20 μg/mL for ECA cells and 10 μg/mL for L1210 cells, making it a valuable candidate for further research in cancer and microbial therapeutics.
Merulidial is an antibiotic and cytotoxic agent characterized by its sesquiterpene dialdehyde structure. It effectively inhibits the germination of spores and hyphal growth in the wood-rotting basidiomycete Heterobasidion annosum and the saprophytic mold Cladosporium cucumerinum. Additionally, Merulidial demonstrates antibacterial and algicidal properties, along with the ability to inhibit DNA synthesis in ECA cells. Notably, it exhibits potent anticancer activity, with IC50 values of 20 μg/mL for ECA cells and 10 μg/mL for L1210 cells, making it a valuable candidate for further research in cancer and microbial therapeutics.
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