Catalog No.
Product Name
Application
Product Information
Citations
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Bacterial Inhibitor
Citrinin is a mycotoxin known for its role as a bacterial inhibitor. It exhibits a range of biological activities, including the regulation of immune cell populations, induction of apoptosis and autophagy in immune cells, and modulation of toll-like receptor expression and cytokine production. Citrinin also induces oxidative stress, leading to apoptosis in oocytes, while low doses demonstrate neuroprotective effects against glutamate-induced excitotoxicity in rat cortical neurons. This compound's diverse mechanisms make it a valuable reagent for research in immunology, neurobiology, and antibacterial applications. -
Anti-bacterial Agent
Pinosylvin is a stilbenoid toxin derived from the heartwood of Pinus species, exhibiting significant anti-bacterial activity. As a resveratrol analogue, it has been shown to induce apoptosis and autophagy in leukemia cells, making it a valuable agent for research in cancer therapy and infectious disease studies. Its unique properties position Pinosylvin as a promising candidate for further exploration in the development of anti-microbial and anti-cancer compounds. -
Antibacterial Agent
5-Fluoroindole is a fluorinated indole derivative that serves as an antibacterial agent. It has been shown to induce reactive oxygen species (ROS) accumulation and initiate apoptosis in bacterial cells. 5-Fluoroindole effectively inhibits the growth of pan-susceptible Mycobacterium tuberculosis H37Rv strains and demonstrates significant bactericidal activity against Pseudomonas syringae pv. actinidiae, with an EC50 of 15.34 µg/mL. This compound is valuable for research focused on tuberculosis and bacterial infections in kiwifruit. Additionally, its fluorinated structure makes it suitable for protein labeling applications. -
Bacterial/Fungal Inhibitor, Preservative Agent
Methylisothiazolinone is a potent bacterial and fungal inhibitor with significant applications as a preservative agent. It activates matrix metalloproteinases (MMPs) in human bronchial epithelial cells, leading to apoptosis and an inflammatory response. Additionally, this compound is linked to the exacerbation of atopic dermatitis in mice through the disruption of Th2/Th17-related immune responses. Furthermore, Methylisothiazolinone has been shown to induce mitochondrial damage in the endothelium of rat cerebral blood vessels, highlighting its potential impact on vascular health. -
Bacterial Inhibitor
Oligomycin B is an antibiotic derived from marine Streptomyces, primarily acting as an inhibitor of ATP synthase in eukaryotic cells. Its mechanism of action leads to a decrease in ATP production, resulting in cellular stress and the induction of apoptosis. Oligomycin B is widely utilized in research focused on mitochondrial function, energy metabolism, and apoptosis-related studies. -
Bacterial Inhibitor
Lactoferrin (17-41) acetate is a peptide derived from residues 17-41 of bovine lactoferrin, primarily functioning as a bacterial inhibitor. It exhibits potent antimicrobial activity against various microorganisms, including Gram-positive and Gram-negative bacteria, viruses, protozoa, and fungi. In addition to its antimicrobial properties, Lactoferrin (17-41) acetate also demonstrates antitumor activities, making it a valuable reagent in studies related to infection control and cancer research. -
Antibacterial Agent/Growth-promoting Agent
Quindoxin is an antibacterial agent that acts by disrupting bacterial cell function. It demonstrates significant growth-promoting activity, particularly in livestock, and has been shown to exhibit dose-dependent mutagenicity against Salmonella typhimurium strains TA98 and TA100. Additionally, Quindoxin is associated with potential DNA damage, highlighting its relevance in studies related to genotoxicity and carcinogenicity. -
Bacterial Transcription Inhibitor
GKL003 is a bacterial transcription inhibitor that targets the interaction interface of RNA polymerase (RNAP) and the sigma factor, with a Ki value of 5.79 nM. By specifically binding to the RNAP β' clamp helix region at the σA factor binding site, GKL003 disrupts the formation of the RNAP holoenzyme and inhibits bacterial transcription initiation complexes. This compound effectively inhibits the growth of both Gram-positive and Gram-negative bacterial strains, including those that are drug-resistant, making it a valuable tool for research applications in microbiology and antibiotic resistance studies. -
Antibacterial Agent
Ostruthin is a natural coumarin compound that exerts antibacterial and antimycobacterial activities. It effectively inhibits the growth of mycobacteria and Staphylococcus aureus, making it valuable in studies of bacterial pathogenesis. Additionally, ostruthin suppresses vascular smooth muscle cell proliferation and de novo DNA synthesis, positioning it as a pertinent tool for research related to mycobacterial infections and cardiovascular as well as cerebrovascular diseases. -
Bacterial Inhibitor
Mequindox is an antimicrobial agent that functions as a bacterial inhibitor by selectively targeting and inhibiting DNA synthesis. This compound demonstrates significant genotoxic and carcinogenic effects in murine models, making it a valuable tool for studying bacterial resistance mechanisms and the potential impacts of antimicrobial agents on genetic material. Its applications extend to research on the safety and efficacy of antimicrobial treatments in various biological systems. -
Bacterial Inhibitor
Silver sulfadiazine is a sulfonamide antibiotic that functions as a bacterial inhibitor through dual mechanisms. The sulfa moiety inhibits bacterial folate absorption, thereby disrupting essential DNA synthesis. Additionally, silver ions released from silver sulfadiazine bind to and disrupt DNA structures, preventing bacterial DNA replication. This compound is widely used in research applications focusing on bacterial growth inhibition and antimicrobial studies. -
Antibacterial Agent
Amicoumacin B is an antibacterial agent produced by the actinomycete strain 04-5195T, primarily targeting bacterial quorum sensing mechanisms. It demonstrates significant inhibitory activity against Chromobacterium violaceum, with a minimum inhibitory concentration (MIC) of 250 µg/mL. Additionally, Amicoumacin B upregulates the expression of bone morphogenetic protein 2 (BMP-2) while simultaneously inhibiting the expression of essential quorum sensing operons vioA, vioB, vioD, and vioE, and enhancing vioC expression. These properties make Amicoumacin B a valuable tool in microbiological research and the study of bacterial communication. -
Bacterial Inhibitor
Fenvalerate is a highly effective bacterial inhibitor, primarily functioning as a protein phosphatase 2B (calcineurin) inhibitor, with an IC50 of 2-4 nM for PP2B-Aα. As a pyrethroid ester, it exhibits significant insecticidal and acaricidal properties. This compound is utilized in various research applications to study protein phosphatase signaling pathways and to explore potential therapeutic targets in bacterial infections. -
Antibacterial Peptide
Golotimod hydrochloride is an immunomodulating peptide that targets antibacterial pathways. This compound enhances the efficacy of antituberculosis therapy by promoting thymic and splenic cell proliferation and improving macrophage functionality. Additionally, Golotimod hydrochloride inhibits STAT3 signaling, thereby modulating the severity and duration of oral mucositis in animal models subjected to radiation or combined treatments. Furthermore, it shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2). -
Antibacterial Peptide
Golotimod TFA is an immunomodulating peptide primarily known for its antibacterial properties. This compound enhances the efficacy of antituberculosis therapy and promotes thymic and splenic cell proliferation while improving macrophage function. It inhibits STAT3 signaling, demonstrating potential in mitigating the duration and severity of oral mucositis in irradiated animal models. Additionally, Golotimod TFA shows promise as a therapeutic agent for recurrent genital herpes simplex virus type 2 (HSV-2). -
Anti-inflammatory/antibacterial Agent
Plumericin is an anti-inflammatory and antibacterial agent that primarily targets key signaling pathways involved in inflammation and cellular stress response. It has been shown to reduce apoptosis, activate Nrf-2, and inhibit both NF-κB and AhR activation, while also blocking STAT3 signaling. Plumericin exhibits inhibitory effects on Mycobacterium tuberculosis growth, making it a valuable compound for studying chronic kidney disease, vascular diseases, inflammatory bowel diseases, peritonitis, and tuberculosis. -
Antibacterial Agent
(±)-Trolline, also known as (±)-Oleracein E, is an isoquinoline alkaloid with notable antibacterial properties against respiratory pathogens. Additionally, it demonstrates antiviral activity against influenza viruses A and B. (±)-Trolline is also a potent inducer of hepatic stellate cell apoptosis, making it a valuable tool for studying liver fibrosis and associated liver disorders. -
Antibacterial Growth Promoter
Nitrovin is an antibacterial growth promoter that targets thioredoxin reductase 1 (TrxR1). It acts by inducing reactive oxygen species (ROS)-mediated non-apoptotic and apoptotic-like cell death. Nitrovin exhibits anticancer activity, demonstrating IC50 values ranging from 1.31 to 6.60 μM in various tumor and normal cell lines, making it a valuable tool for research in cancer and antibacterial studies. -
Antibacterial Agent
Antibacterial Agent 292 is a 3-pyrazolylindole derivative targeting bacterial pathogens. This compound exhibits potent inhibitory activity against Xanthomonas oryzae pv oryzae (Xoo) and Xanthomonas axonopodis pv citri (Xac), with EC50 values of 2.54 and 3.49 μg/mL, respectively. It suppresses biofilm formation, bacterial motility, and extracellular polysaccharide production while inducing morphological changes and promoting ROS accumulation, leading to bacterial apoptosis. Additionally, it down-regulates genes associated with the type VI secretion system (T6SS), making it a valuable tool for research on rice bacterial blight and citrus canker. -
Bacterial
(-)-Isoledene primarily functions as an antibacterial agent, exhibiting significant antibacterial and anti-inflammatory activities. This natural organic compound has been investigated for its role in the synthesis of various compound intermediates, highlighting its potential applications in compound development and pharmaceutical research. Its diverse biological activity positions it as a valuable reagent for studies related to bacterial infections and inflammation. -
Bacterial Inhibitor
(Z)-Methyl tetradec-9-enoate functions as a bacterial inhibitor, primarily exerting its cytotoxic effects in human prostate cancer LNCaP cells through the induction of apoptosis and necrosis. Isolated from S. repens fruit extract, this compound also demonstrates antifungal activity, effectively inhibiting the germination of Candida albicans with a minimum inhibitory concentration (MIC) of 9 μM in vivo. Its applications extend to studies in both cancer research and microbiology, making it a valuable reagent for understanding cellular processes and developing therapeutic strategies. -
Bacterial Metabolite Xie
Collismycin A is a bacterial metabolite targeting multiple cellular pathways, originally isolated from Streptomyces. Exhibiting antibacterial, antiproliferative, and neuroprotective properties, it demonstrates activity against various bacteria and fungi (MICs ranging from 6.25 to 100 μg/mL). Notably, Collismycin A inhibits the proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells, with IC50 values of 0.3, 0.6, and 0.3 μM, respectively, while demonstrating minimal impact on MDA-MB-231 breast cancer cells (IC50 > 100 μM). Furthermore, it forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, where the presence of iron ions can attenuate its antiproliferative effects in HeLa cells, and it exhibits protective effects against neuronal cell death in zebrafish larvae models. -
Antibacterial Agent/eEF2K Inhibitor
Cefatrizine is a broad-spectrum cephalosporin antibiotic that primarily targets bacterial infections while also acting as an eEF2K inhibitor. This compound exhibits anti-proliferative activity in human breast cancer cells, inducing endoplasmic reticulum stress and subsequent cell death. Cefatrizine is a valuable reagent for research applications in understanding mechanisms of cancer therapy and exploring antibacterial efficacy. -
Antibacterial Agent
Chlorhexidine acetate hydrate is a cationic antimicrobial agent that targets microbial cell membranes. By non-specifically binding to cell membrane phospholipids, it disrupts membrane integrity, leading to leakage of cellular contents and bacterial cell death. This compound exhibits broad-spectrum bactericidal activity against both Gram-positive and Gram-negative bacteria. Its ability to interfere with membrane permeability and induce protein precipitation makes it valuable for research applications focused on microbial growth inhibition and mechanisms of cell death. -
Antitumor/ Antibacterial Agent
Epanorin is a secondary metabolite derived from the Acarospora lichenic species, primarily targeting tumor cells and bacterial pathogens. It exhibits potent antitumor activity by inhibiting cancer cell proliferation, reducing reactive oxygen species (ROS) production, and inducing cell cycle arrest in the G0/G1 phase. Additionally, Epanorin demonstrates antibacterial properties, making it valuable for research applications focused on cancer treatment and bacterial infections, including studies on breast cancer and Streptococcus pneumoniae infections. -
Antibacterial Agent
Deoxymikanolide is an orally active antibacterial agent that primarily targets catalase (CAT), peroxidase (POD), and superoxide dismutase (SOD) activities. It enhances glycan and phosphorus metabolism, increases electrical conductivity, and elevates levels of intrabacterial reactive oxygen species (ROS) and malondialdehyde (MDA). These actions result in cell shrinkage, cytoplasmic damage, and disruption in Ralstonia solanacearum. Additionally, Deoxymikanolide demonstrates efficacy in inhibiting acetic acid-induced writhing in mice, making it a valuable tool for research on bacterial wilt. -
Antibacterial Peptide
KSL-W is a multifunctional antibacterial peptide primarily targeting immune regulation. It exhibits significant chemotactic effects on neutrophils and promotes F-actin polymerization through the Gαi protein signaling pathway. Additionally, KSL-W effectively inhibits the production of reactive oxygen species (ROS) in neutrophils. This peptide is valuable for research focused on infection control and the regulation of inflammatory processes. -
Antibacterial Agent
Aloe vera, a natural herbal extract, exhibits significant antibacterial activity. It is recognized for its anti-inflammatory and antioxidant properties, making it a valuable candidate for research applications in areas such as tumor biology, diabetes, bone disorders, and cardiovascular health. Its diverse biological effects support its potential use as a therapeutic agent in various biomedical studies. -
Antibacterial Agent
ROS inducer 9 is an antibacterial agent that functions by inhibiting glutathione (GSH) activity and elevating reactive oxygen species (ROS) levels. With a minimum inhibitory concentration (MIC) of 0.25 μg/mL against E. coli, it demonstrates potent antibacterial properties. Additionally, ROS inducer 9 exhibits low toxicity to erythrocytes and RAW 264.7 cells, making it suitable for various biological research applications in exploring oxidative stress responses in bacterial infections. -
Anti-bacterial Agent
Anti-MRSA agent 36 is an antibacterial compound that exhibits potent activity against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 1 μg/mL. This agent specifically targets phosphatidylglycerol (PG) in bacterial membranes, leading to compromised membrane integrity, DNA leakage, and increased reactive oxygen species (ROS) production. Characterized by low cytotoxicity and minimal hemolytic effect, Anti-MRSA agent 36 also demonstrates a reduced propensity for inducing drug resistance and good plasma stability, making it suitable for research involving skin abscess and systemic infection models. -
Antibacterial Agent
Antibacterial Agent 308 is an antibacterial compound that selectively targets bacterial membranes by binding to phosphatidylethanolamine, leading to membrane polarization disruption and increased intracellular reactive oxygen species (ROS) levels. This agent exhibits significant anti-biofilm activity against Staphylococcus aureus and demonstrates potent anti-methicillin-resistant Staphylococcus aureus (MRSA) efficacy. Its unique mechanism makes it a valuable tool for research focused on combating bacterial infections and biofilm-related challenges. -
Antibacterial Agent
3,4-Dimethoxychalcone acts as an antibacterial agent by inducing deacetylation of cytoplasmic proteins, thereby promoting autophagy flux. This compound is relevant for research applications focused on disease mechanisms related to cardiac and cancer biology, offering potential pathways for therapeutic intervention. Researchers may explore its effects on cellular processes and its role as a caloric restriction mimetic in various experimental models. -
Antibacterial Agent
BWC0977 is an antibacterial agent that primarily targets bacterial DNA replication by inhibiting DNA gyrase and topoisomerase IV. This compound demonstrates potent activity with a minimum inhibitory concentration (MIC90) ranging from 0.03 to 2 µg/mL against multi-drug resistant Gram-negative bacteria. BWC0977 is suitable for research applications involving the study of bacterial resistance mechanisms and the development of new antimicrobial strategies. -
Antibacterial Agent
BWC0977 formic is an antibacterial agent that targets bacterial DNA replication by inhibiting DNA gyrase and topoisomerase IV. It demonstrates significant antibacterial activity, with a minimum inhibitory concentration (MIC90) ranging from 0.03 to 2 µg/mL against multi-drug resistant Gram-negative bacteria. This compound is valuable for research applications focused on combating antibiotic resistance and exploring therapeutic strategies for resistant infections. -
Antibacterial Agent
Antibacterial Agent 89 is a potent antibacterial compound that targets bacterial transcription processes. It exhibits significant anti-clostridial activity by inhibiting the release of cytotoxins and disrupting the β’CH-σ interaction. This compound is useful for research applications focused on bacterial pathogenesis and the development of novel antibacterial strategies. -
Bacterial DNA Gyrase/Topo IV Inhibitor
GC-072 is a selective inhibitor of bacterial DNA gyrase and Topoisomerase IV, demonstrating potent antibacterial activity. This 4-oxoquinolizine antibiotic exhibits efficacy against a wide range of bacterial strains, including Gram-positive, Gram-negative, and multidrug-resistant organisms. Importantly, GC-072 does not interfere with human topoisomerases I and II, making it a suitable candidate for studying bacterial infections. Its bactericidal action against Burkholderia pseudomallei is significant, as it supports dose-dependent survival rates in mice during lethal inhalational models, highlighting its potential in melioidosis research. -
Bacterial DNA Gyrase B Inhibitor
DNA Gyrase-IN-3 is a specific inhibitor of bacterial DNA gyrase B, exhibiting IC50 values ranging from 5.41 to 15.64 µM against E. coli DNA gyrase. This compound demonstrates significant anti-tubercular and antibacterial activity, making it a valuable tool for microbial research. Its mechanism of action is relevant in studies aimed at developing new antibacterial agents targeting bacterial DNA replication and transcription processes. -
Bacterial Inhibitor
CI-990 (PD-131112) is a selective inhibitor of bacterial DNA gyrase, targeting key enzymes involved in DNA replication and repair. It exhibits potent antibacterial activity and is especially relevant for studying Enterococcal infections, including endocarditis and sepsis. This compound can serve as a valuable tool in microbiological research to understand bacterial resistance mechanisms and develop therapeutic strategies. -
Bacterial Transcription Inhibitor
CUHK242 is a selective bacterial transcription inhibitor that effectively disrupts RNA synthesis within bacterial cells. It demonstrates a minimum inhibitory concentration (MIC) of 2 μg/mL against the B. subtilis reporter strain BS2019 and exhibits antimicrobial activity against Staphylococcus aureus. This compound is useful for research applications focused on understanding bacterial gene expression and studying the mechanisms of antibiotic resistance. -
Anti-Bacterial Agent
(Rac)-Besifloxacin hydrochloride is a fourth-generation fluoroquinolone antibiotic that acts as a potent inhibitor of DNA gyrase and topoisomerase IV. This compound exhibits broad-spectrum antibacterial activity against both Gram-negative and Gram-positive aerobic and anaerobic bacteria, making it valuable in combating drug resistance. Additionally, (Rac)-Besifloxacin hydrochloride possesses anti-inflammatory properties, and it is relevant in the study of bacterial conjunctivitis. -
Bacterial DNA Gyrase B Inhibitor
DNA Gyrase-IN-2 is a potent inhibitor of bacterial DNA gyrase B, demonstrating IC50 values of 3.29-10.49 µM for Escherichia coli and 4.41-5.61 µM for Mycobacterium tuberculosis. This compound exhibits significant anti-tubercular and antibacterial activity, making it valuable for research focused on bacterial replication and antibiotic development. Its specific targeting of DNA gyrase B positions it as a promising candidate for further investigation in treating bacterial infections. -
Antibacterial Agent
S-MGB-234 is an antibacterial agent that functions as a minor groove binder, specifically targeting the causative agents of Animal African Trypanosomiasis (AAT). This compound demonstrates potent in vitro activity against Trypanosoma congolense and Trypanosoma vivax, the primary pathogens responsible for AAT. Notably, S-MGB-234 exhibits a unique resistance profile, lacking cross-resistance with existing diamidine agents and not utilizing the transporters commonly associated with diamidines. -
Antibacterial Agent
Lavofloxacin lactate is an antibacterial agent that primarily targets DNA gyrase and topoisomerase IV, leading to the inhibition of DNA replication and repair in bacteria. This broad-spectrum antimicrobial compound exhibits potent bactericidal activity against a wide range of bacterial species. Researchers can utilize Lavofloxacin lactate to investigate bacterial resistance mechanisms, including the analysis of resistance genes and mutations. -
Antibacterial Agent
A-65282 is an antibacterial agent that inhibits P4 DNA unknotting, exhibiting an IC50 value of 8 µg/mL. This compound induces DNA breakage through the action of calf thymus topoisomerase II, making it a valuable tool for studying DNA replication and repair mechanisms. Its targeted enzymatic disruption highlights its potential in antibacterial research contexts. -
Antibacterial Agent
Anti-MRSA agent 28 is an antibacterial agent specifically designed to target multidrug-resistant (MDR) gram-positive bacterial strains. With minimum inhibitory concentrations (MICs) ranging from 0.06 to 0.125 μg/mL, it effectively inhibits bacterial growth by targeting DNA polymerase IIIC, demonstrating an IC50 of 3.80 μg/mL. This compound exhibits strong antibacterial activity and has anti-inflammatory properties, making it a valuable tool for research applications related to the treatment of gram-positive infections. -
Antibacterial Agent
DV-7751A is a fluoroquinolone antibiotic that primarily inhibits the supercoiling activity of DNA gyrases. This compound demonstrates significant antimicrobial activity against a range of bacterial strains, including Streptococcus pneumoniae, Streptococcus pyogenes, and Peptostreptococcus species. Additionally, DV-7751A exhibits a rapid bactericidal effect against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa, making it a valuable reagent for research in antibacterial therapeutics. -
Insecticide/Antibacterial Agent
Satranidazole is an orally active insecticide and antimicrobial agent that primarily targets DNA through the formation of reduced nitro intermediates. By inducing helix instability and strand breakage, it exhibits notable antitrichomonal activity against organisms such as Trichomonas vaginalis and Trichomonas foetus, as well as antiamoebic effects in rodent models of hepatic and caecal amoebiasis. Additionally, Satranidazole has been shown to inhibit the replication of bacteriophage φX174 DNA. This compound is valuable for research exploring caecal amoebiasis, trichomoniasis, and anaerobic bacterial infections. -
Antibacterial/anti-inflammatory Agent
Sinapaldehyde is a methoxyphenol that primarily functions as a selective COX-2 inhibitor with an IC50 of 47.8 µM. This compound exhibits notable antibacterial and anti-inflammatory properties, demonstrating efficacy against both Gram-positive and Gram-negative bacteria. Additionally, Sinapaldehyde possesses antioxidant activity through its ability to scavenge DPPH free radicals, with an IC50 of 172 μM, making it a valuable reagent for research in inflammation and microbial resistance. -
Antibacterial Agent
1-Tetradecanol is a straight-chain saturated fatty alcohol that serves as an effective antibacterial agent. Isolated from Myristica fragrans, it exhibits notable antibacterial and anti-inflammatory properties, particularly in the context of periodontitis. This compound can be utilized in research applications focusing on antimicrobial activity and the modulation of inflammatory responses. -
Antibacterial Agent
Terminolic acid is a pentacyclic triterpene glycoside that acts as an antibacterial agent. It exhibits significant antibacterial activity against Staphylococcus aureus, Escherichia coli, and Enterococcus faecalis, with minimum inhibitory concentrations (MICs) ranging from 64 to 256 μg/mL. Terminolic acid also demonstrates the ability to inhibit pro-inflammatory cytokines by binding to the receptor active sites of IL-1β and IL-6, contributing to a reduction in IL-8 levels. This compound is utilized in research targeting colon cancer and inflammatory conditions.
