Catalog No.
Product Name
Application
Product Information
Citations
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FREP1 Inhibitor
P-orlandin is a specific inhibitor of FREP1, a protein that mediates the binding of Plasmodium gametocytes and ookinetes. This fungal metabolite demonstrates potent activity in blocking Plasmodium falciparum infections in mosquito vectors, making it a valuable tool for research in malaria transmission and vector control studies. Its unique mode of action offers insights into potential strategies for disrupting the lifecycle of malaria parasites. -
Antimalarial Drug
Chevalone C is a meroterpenoid fungal metabolite that exhibits potent antimalarial activity, demonstrating an IC50 value of 25.00 μg/mL. In addition to its antimalarial properties, Chevalone C displays anti-proliferative effects against various cancer cell lines, including colon HCT116, liver HepG2, and melanoma A375. This compound is useful for research applications in the study of malaria and cancer therapeutics. -
Antifungal Agent
Antibacterial agent 230 is an antifungal agent targeting fluconazole-resistant fungi. It exhibits a minimal inhibitory concentration (MIC) ranging from 2.0 to 16.0 μg/mL, demonstrating significant efficacy against resistant strains. This compound is suitable for research applications focused on fungal resistance mechanisms and the development of new antifungal therapies. -
Polyketide
Reveromycin C is a polyketide compound originally derived from Streptomyces, exhibiting significant antifungal activity against Candida albicans, with minimum inhibitory concentrations of 2.0 μg/mL at pH 3 and above 500 μg/mL at pH 7.4. It inhibits EGF-induced mitogenic activity in Balb/MK mouse epidermal cells and effectively reverses the morphology of sarcoma-virus-transformed NRK rat kidney cells with an EC50 of 1.58 μg/mL. Additionally, Reveromycin C suppresses the proliferation of KB cells and K562 human chronic myelogenous leukemia cells, both with an IC50 of 2.0 μg/mL, making it a valuable tool for cancer research and antifungal studies. -
Antiviral Agent
γ-Carboline is a bioactive compound primarily functioning as an antiviral agent. It exhibits significant antiviral activity against Bovine Viral Diarrhea Virus (BVDV) with an EC50 of 2.0 μM. Additionally, derivatives of γ-Carboline have demonstrated antibacterial, antifungal, and antitumor properties, making it a valuable tool for various research applications in virology and broader therapeutic studies. -
Quorum Sensing Inhibitor
Aculene D is a quorum sensing inhibitor derived from fungal metabolites that targets the signaling mechanisms in bacteria. It effectively reduces violacein production in Chromobacterium violaceum CV026 cultures induced by N-hexanoyl-L-homoserine lactone (C6-HSL) at sub-inhibitory concentrations. This compound is valuable for research exploring bacterial communication and the modulation of biofilm formation, with potential applications in combating antibiotic resistance and developing new antimicrobial strategies. -
Streptomycin Biosynthesis Inducer
A-Factor is a potent inducer of streptomycin biosynthesis in the inactive mutant strain of Streptomyces griseus. Additionally, A-Factor promotes spore formation during the conidial development of Magnaporthe oryzae. This reagent is valuable for researchers studying antibiotic production and fungal development processes. -
Antibiofilm Agent
Antibiofilm agent-14 is a potent antibiofilm agent targeting fungal biofilm formation. It exhibits notable antifungal activity against Candida albicans strain SC5314, demonstrating a minimum inhibitory concentration (MIC) of 50 μM. This compound is valuable for research applications focusing on biofilm-related infections and strategies to combat fungal resistance. -
Antifungal Agents
Bensuldazic acid is a lipophilic 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivative functioning as an antifungal agent. It exhibits significant antifungal activity, making it a valuable compound for research in fungal infections. Bensuldazic acid can also serve as a prodrug model, facilitating studies in drug development and fungal pathogenesis. -
Antimicrobial Agent
9,12,13-Trihydroxy-10-octadecenoic acid acts primarily as an antimicrobial agent. This compound exhibits significant antibacterial and antifungal properties, making it valuable for various biological research applications. It is particularly useful in studies focused on infection control and the development of novel antimicrobial therapies. -
Antifungal Agents
Bensuldazic acid sodium is a sodium salt of a 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine-2-thione (THTT) derivative known for its lipophilic properties. It exhibits significant antifungal activity, functioning effectively as a prodrug model in various studies. This compound is utilized in research focused on antifungal agents and can aid in the development of novel therapeutic strategies against fungal infections. -
GlcN-6-P Synthase Inhibiotor
FMDP is a selective inhibitor of GlcN-6-P Synthase, demonstrating significant anti-candidal activity. Additionally, when covalently linked to polyethylene glycol in nanoparticle form, FMDP exhibits strong anticancer properties. This compound serves as a valuable tool in research applications focused on fungal infections and cancer therapeutics. -
AgrA Quorum-sensing Inhibitor
Apicidin D2 is a specific inhibitor of the accessory gene regulator A (AgrA), which plays a pivotal role in bacterial quorum sensing. This fungal metabolite demonstrates notable anti-virulence properties by effectively suppressing AgrA activation in Staphylococcus aureus, including methicillin-resistant strains (MRSA), without exhibiting biocidal effects. Apicidin D2 is a valuable reagent for research focused on understanding MRSA infections and developing strategies to combat quorum-sensing related pathogenicity. -
Anticancer Agent
Previridicatumtoxin is a fungal metabolite known for its antibacterial and anticancer properties. Derived from the organism P. aethiopicum, this compound demonstrates significant biological activity against cancer cells and has potential applications in cancer research and studies related to infections. Its unique mechanism of action makes it a valuable tool for exploring therapeutic strategies in oncology and microbiology. -
triazole fungicide
Ipconazole is a triazole fungicide that primarily targets the biosynthesis of ergosterol, a key component of fungal cell membranes. It exhibits potent antifungal activity, making it effective in the control of various fungal pathogens that affect rice seed and other crops. This reagent is valuable for research applications focused on plant protection strategies and the study of fungal resistance mechanisms. -
Antifungal Agent
Ayapin is a phytoalexin primarily derived from sunflower, functioning as a potent antifungal agent. It effectively inhibits the growth of Sclerotinia sclerotiorum, exhibiting an IC50 value of 0.16 mM for 50% inhibition. Ayapin is valuable for research applications focused on the mechanisms of antifungal resistance and strategies to combat sclerotinia infections. -
Anti-mycotic Agent
Tioxaprofen is an effective anti-mycotic agent that targets Trichophyton mentagrophytes and T. rubrum. Its primary mechanism of action involves acting as a potent uncoupling agent of mitochondrial respiration, disrupting the energy production in fungal cells. This compound is valuable for research focused on fungal infections and mitochondrial function, providing insights into potential therapeutic avenues. -
Antimicrobial Agent
Antimicrobial agent-30 is an effective antimicrobial agent that targets various bacterial and fungal strains. It demonstrates minimum inhibitory concentration (MIC) values ranging from 18.7 to 21.0 µg/mL against Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Pseudomonas aeruginosa, Aspergillus niger, and Aspergillus fumigatus. This compound is suitable for research applications involving antimicrobial susceptibility testing and the development of new antimicrobial therapies. -
Anthraquinone
Rheoemodin is an anthraquinone compound with notable antibacterial properties. Isolated from Cordyceps morakotii BCC 56811, it demonstrates significant antibacterial activity against Acinetobacter baumannii, with a minimum inhibitory concentration of 12.5 μg/mL. Additionally, Rheoemodin exhibits weak to moderate activity against mycobacterial and fungal pathogens, as well as anticancer effects in breast cancer and small cell lung cancer models. Its diverse biological activities make Rheoemodin a valuable tool for research in microbiology and cancer therapeutics. -
Aldehyde Compound
Phellandral is an aldehyde compound primarily sourced from Eucalyptus camaldulensis and Thymus seravschanicus. This compound demonstrates potent antifungal activity, particularly against the plant pathogen Aspergillus flavus. Additionally, phellandral contributes to the antibacterial properties of eucalyptus essential oil, making it valuable for research in phytopathology and natural product development. -
Anticandidal Agent
Anticandidal agent-1 is a potent broad-spectrum agent targeting Candida species, exhibiting significant anticandidal activity against Candida albicans and Candida glabrata, with MIC50 values of 8.65 and 13.51 μg/mL, respectively. This compound effectively inhibits biofilm formation by disrupting hyphal elongation and filamentation, making it a valuable tool for studying candidiasis and developing antifungal treatments. Its mechanism of action positions it as a crucial reagent for research in fungal pathogenesis and infection control. -
Microbial Metabolite
Benanomicin A is a microbial metabolite derived from Actinomycetes, known for its antifungal properties. It demonstrates significant inhibitory effects on HIV-1 viral infection in MT-4 cells. This compound is useful in research applications targeting fungal infections and viral replication mechanisms. -
Antibiofilm Agent
1,3-β-Glucanase targets the β-1,3-glucan component of the biofilm matrix in Candida albicans. By degrading this polysaccharide, it effectively disrupts the biofilm structure, thereby enhancing the efficacy of antimicrobial treatments. This enzyme is utilized as an antibiofilm agent in various research applications focused on fungal infections and biofilm-related challenges. -
Antimicrobial Agent
Lapyrium chloride is a broad-spectrum antimicrobial agent that targets a variety of microorganisms. It exhibits potent antiseptic and disinfectant properties, making it suitable for use in both clinical and laboratory settings. This reagent is ideal for applications involving the control of bacterial and fungal contamination. -
Dihydroisocoumarin Derivative
Aspergillumarin B is a dihydroisocoumarin derivative isolated from the endophytic fungus Aspergillus sp. It exhibits weak antibacterial activity against Staphylococcus aureus and Bacillus subtilis. This compound is of interest in biological research for its potential applications in studying antibacterial mechanisms and fungal metabolites. -
DHPS Inhibitor
Dihydropteroate synthase-IN-1 is a potent inhibitor of dihydropteroate synthase (DHPS), primarily targeting the folate biosynthesis pathway. This compound exhibits significant antimicrobial and antifungal properties, making it valuable for research in microbial resistance and pathogenicity studies. Additionally, Dihydropteroate synthase-IN-1 has implications in diagnostics as a potential radio imaging agent, advancing the exploration of therapeutic interventions. -
MabA (FabG1) Inhibitor
FabG1-IN-1 is a selective inhibitor of MabA (FabG1), exhibiting an IC50 of 38 µM. This compound effectively impedes the enzymatic activity of FabG1, playing a crucial role in fatty acid biosynthesis. FabG1-IN-1 is applicable in research focusing on metabolic pathways and the development of antifungal therapies targeting lipid synthesis. -
Antimicrobial Agent
Sulochrin is an antimicrobial agent derived from the metabolite produced by Aspergillus terreus var. aureus. This compound exhibits significant antimicrobial activity, making it valuable in the study of microbial interactions and the development of antifungal treatments. Sulochrin is useful for research applications involving infection models, as well as in exploring the biochemical pathways related to antimicrobial resistance. -
Asperlicin
Asperlicin D is an metabolite derived from the Aspergillus alliaceus strain (ATCC 20656), primarily involved in the regulation of fungal biosynthesis. It exhibits antifungal and antibacterial activities through inhibition of various biological pathways. Due to its potential therapeutic properties, Asperlicin D is of interest in studies related to natural product chemistry and antimicrobial drug development. -
DGK Inhibitor
Cochlioquinone A is a potent diacylglycerol kinase (DGK) inhibitor, exhibiting ATP-competitive properties with a Ki value of 3.1 μM. Isolated from the fungal species Drechslera sacchari, Cochlioquinone A serves as a valuable tool for studying DGK's role in cellular signaling pathways. Its inhibitory effects on DGK activity make it pertinent for research in lipid signaling and related biological processes. -
Aflatoxin B1 Metabolite
Aflatoxicol is a primary metabolite of aflatoxin B1, generated by the fungal species Rhizopus. This compound exhibits mutagenic and carcinogenic properties, making it a critical subject of study in toxicology and cancer research. Aflatoxicol serves as an important reagent for analyzing the metabolic pathways and biological effects of aflatoxin exposure. Its use can aid in evaluating the risks associated with mycotoxin contamination in food and agricultural products. -
Emodin Metabolite
2-Hydroxyemodin, an active metabolite of emodin, primarily targets hepatic microsomes. This anthraquinone, derived from fungal metabolites and found in rhubarb, exhibits mutagenic activity in Salmonella typhimurium TA1537 without the need for an activation system. It is utilized in research to investigate metabolic pathways and genetic stability. -
ACAT Inhibitor
Phenylpyropene A is a potent inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), exhibiting an IC50 of 0.8 μM. This fungal metabolite has shown significant biological activity in modulating cholesterol esterification. Its application is particularly relevant in research focused on cholesterol metabolism and related disorders. -
ACAT Inhibitor
Terpendole I is a fungal indoloditerpene that functions as an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, exhibiting an IC50 value of 145 µM. This compound demonstrates significant biological activity in modulating cholesterol metabolism, making it a valuable tool for studying lipid regulation and related metabolic disorders. Terpendole I can be utilized in research focused on atherogenesis, cholesterol homeostasis, and the therapeutic exploration of cardiovascular diseases. -
Acyltransferase Inhibitor
Amidepsine D is an acyltransferase inhibitor derived from the fungal metabolite isolated from the culture broth of Humicola sp. FO-2942. It specifically inhibits diacylglycerol acyltransferases (DGAT), playing a crucial role in lipid metabolism regulation. This compound is valuable for research applications focused on examining lipid biosynthesis pathways and exploring potential therapeutic targets in metabolic disorders. -
ACAT Inhibitor
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), derived from the mycelial cake of Gibberella lateritium IFO 7188. This compound exhibits significant biological activity by inhibiting the growth of various human cancer cell lines, as well as displaying antibacterial effects against gram-positive bacteria and antifungal activity against Candida albicans. Lateritin is a valuable tool for research in cancer therapeutics and the study of lipid metabolism. -
ACAT Inhibitor
Glisoprenin A is an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), targeting cholesterol metabolism. It has demonstrated significant activity in inhibiting the formation of appressorium on hydrophobic surfaces in the fungal pathogen Magnaporthe grisea. This compound is valuable for research into fungal plant pathogens and cholesterol metabolism dynamics. -
ACAT Inhibitor
Glisoprenin D is an ACAT inhibitor that selectively targets cholesterol acyltransferase, thereby influencing lipid metabolism. It has been shown to inhibit the formation of appressorium on the hydrophobic surfaces of Magnaporthe grisea, making it a valuable tool for studying fungal pathogenesis and plant-fungal interactions. This compound has potential applications in both basic and applied research within mycology and plant sciences. -
ACAT Inhibitor
Glisoprenin C is a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), which plays a crucial role in cholesterol metabolism. By inhibiting ACAT, Glisoprenin C effectively disrupts cholesterol esterification, impacting the pathogenicity of organisms such as Magnaporthe grisea by preventing appressorium formation on hydrophobic surfaces. This compound is valuable in studying cholesterol-related pathways and evaluating potential therapeutic strategies against fungal pathogens. -
ACAT Inhibitor
Glisoprenin E is an ACAT inhibitor that effectively inhibits cholesterol acyltransferase activity. This compound has demonstrated biological activity by preventing the formation of appressorium on hydrophobic surfaces in the phytopathogen Magnaporthe grisea. Its applications are significant in studying fungal pathogenicity and the role of lipid metabolism in plant-fungal interactions. -
Mitotic kinesin Inhibitor
Mitotic kinesin-IN-1 hydrochloride is a potent inhibitor of mitotic kinesin, specifically designed to disrupt the process of mitosis. This compound effectively impairs cell proliferation and has applications in cancer research, as well as investigations into cardiac hypertrophy, immune and inflammatory disorders, and fungal infections. Its ability to hinder mitotic activity makes it a valuable tool for studying various cellular processes and pathways related to these conditions. -
Griseofulvin Metabolite
6-O-Demethyl griseofulvin is a significant metabolite of Griseofulvin, primarily acting on fungal cell division by inhibiting microtubule formation. This compound demonstrates antifungal activity, making it valuable in studying the efficacy of antifungal treatments and the metabolic pathways involving Griseofulvin. Its applications extend to research focused on dermatophyte infections and fungal resistance mechanisms. -
Metabolite
BTS44596 (Prochloraz-desimidazole-formylamino) is a key metabolite of the antifungal agent Prochloraz, primarily targeting regulatory monitoring applications. This compound serves as a critical target analyte for assessing Prochloraz residue limits in fruits and vegetables. Additionally, it facilitates simultaneous detection using LC-MS/MS methodology, making it an essential tool for food safety and environmental studies. -
Fungicidal Agent
N,N-Bis(3-aminopropyl)dodecylamine serves as a potent fungicidal agent targeting Aspergillus niger. It exerts its antifungal activity by inducing oxidative stress and modulating the activity of various antioxidant and mitochondrial enzymes in a concentration- and time-dependent manner. Additionally, this compound disrupts fungal organelles and alters mitochondrial morphology, leading to impaired mitochondrial functions. N,N-Bis(3-aminopropyl)dodecylamine is valuable for research into fungicidal mechanisms and the role of oxidative stress in Aspergillus niger. -
Melanin Biosynthesis Inhibitor
Scytalol A is a selective inhibitor of dihydroxynaphthalene melanin biosynthesis in Lachnellula sp. A32-89, effectively disrupting melanin production without affecting the growth of the organism. This compound is valuable for research investigating melanin biosynthesis pathways and can be utilized in studies focused on fungal pigmentation and its applications in various biotechnological fields. -
Drug Derivative
Fluopicolide is a novel drug derivative with a primary mechanism targeting specific protein interactions. It exhibits significant antifungal activity, making it suitable for studying plant pathogen resistance and developing effective agricultural fungicides. Fluopicolide is particularly valuable for research applications focused on crop protection and plant disease management strategies. -
Alternaria Metabolite
4-Hydroxyalternariol is a metabolite derived from the fungus Alternaria. It exhibits significant cytotoxic activity and serves as a potent inhibitor of various cell proliferation pathways. This compound is valuable in research focused on mycotoxin studies, apoptosis, and cancer biology, facilitating investigations into the biological effects of fungal metabolites on human health. -
Metabolite
(Z)-2-Octenoic acid is the Z-isomer of 2-Octenoic acid, a significant metabolite derived from Mucor species. It plays a role in various biochemical pathways and can be utilized in studies exploring fungal metabolism and organic compound synthesis. This compound may aid in the investigation of microbial interactions and the functional roles of metabolites in ecological systems. -
Secondary Metabolite
4-Hydroxyscytalone is a microbial secondary metabolite isolated from the oak fungus Diplodia corticola. This compound exhibits toxicity toward Artemia salina with an LC50 value of 90.6 μg/mL, indicating its potential as a bioactive agent. While it does not demonstrate significant antifungal activity, 4-Hydroxyscytalone may serve as a valuable tool in cancer therapy research, facilitating investigations into novel treatment strategies. -
Squalene Synthase Inhibitor
Squalestatin 3 is a potent squalene synthase inhibitor, demonstrating an IC50 of 6 nM. This secondary metabolite, isolated from the fungus Phoma, plays a critical role in regulating the biosynthesis of sterols and terpenes. It is valuable for research applications focused on cholesterol biosynthesis, antifungal research, and the exploration of lipid metabolism pathways.
