Shop By
Catalog No.
Product Name
Application
Product Information
Citations
-
ACAT Inhibitor
Phenylpyropene A is a potent inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), exhibiting an IC50 of 0.8 μM. This fungal metabolite has shown significant biological activity in modulating cholesterol esterification. Its application is particularly relevant in research focused on cholesterol metabolism and related disorders. -
ACAT Inhibitor
Terpendole I is a fungal indoloditerpene that functions as an acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor, exhibiting an IC50 value of 145 µM. This compound demonstrates significant biological activity in modulating cholesterol metabolism, making it a valuable tool for studying lipid regulation and related metabolic disorders. Terpendole I can be utilized in research focused on atherogenesis, cholesterol homeostasis, and the therapeutic exploration of cardiovascular diseases. -
Acyltransferase Inhibitor
Amidepsine D is an acyltransferase inhibitor derived from the fungal metabolite isolated from the culture broth of Humicola sp. FO-2942. It specifically inhibits diacylglycerol acyltransferases (DGAT), playing a crucial role in lipid metabolism regulation. This compound is valuable for research applications focused on examining lipid biosynthesis pathways and exploring potential therapeutic targets in metabolic disorders. -
ACAT Inhibitor
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), derived from the mycelial cake of Gibberella lateritium IFO 7188. This compound exhibits significant biological activity by inhibiting the growth of various human cancer cell lines, as well as displaying antibacterial effects against gram-positive bacteria and antifungal activity against Candida albicans. Lateritin is a valuable tool for research in cancer therapeutics and the study of lipid metabolism. -
ACAT Inhibitor
Glisoprenin A is an inhibitor of acyl-CoA: cholesterol acyltransferase (ACAT), targeting cholesterol metabolism. It has demonstrated significant activity in inhibiting the formation of appressorium on hydrophobic surfaces in the fungal pathogen Magnaporthe grisea. This compound is valuable for research into fungal plant pathogens and cholesterol metabolism dynamics. -
ACAT Inhibitor
Glisoprenin D is an ACAT inhibitor that selectively targets cholesterol acyltransferase, thereby influencing lipid metabolism. It has been shown to inhibit the formation of appressorium on the hydrophobic surfaces of Magnaporthe grisea, making it a valuable tool for studying fungal pathogenesis and plant-fungal interactions. This compound has potential applications in both basic and applied research within mycology and plant sciences. -
ACAT Inhibitor
Glisoprenin C is a selective inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), which plays a crucial role in cholesterol metabolism. By inhibiting ACAT, Glisoprenin C effectively disrupts cholesterol esterification, impacting the pathogenicity of organisms such as Magnaporthe grisea by preventing appressorium formation on hydrophobic surfaces. This compound is valuable in studying cholesterol-related pathways and evaluating potential therapeutic strategies against fungal pathogens. -
ACAT Inhibitor
Glisoprenin E is an ACAT inhibitor that effectively inhibits cholesterol acyltransferase activity. This compound has demonstrated biological activity by preventing the formation of appressorium on hydrophobic surfaces in the phytopathogen Magnaporthe grisea. Its applications are significant in studying fungal pathogenicity and the role of lipid metabolism in plant-fungal interactions. -
Mitotic kinesin Inhibitor
Mitotic kinesin-IN-1 hydrochloride is a potent inhibitor of mitotic kinesin, specifically designed to disrupt the process of mitosis. This compound effectively impairs cell proliferation and has applications in cancer research, as well as investigations into cardiac hypertrophy, immune and inflammatory disorders, and fungal infections. Its ability to hinder mitotic activity makes it a valuable tool for studying various cellular processes and pathways related to these conditions. -
CYP51 Inhibitor
CYP51-IN-21 is a potent inhibitor of cytochrome P450 51 (CYP51), demonstrating significant antifungal activity against various pathogenic fungi, including drug-resistant strains. By targeting CYP51, CYP51-IN-21 disrupts the biosynthesis of essential sterols, impairing fungal growth and viability. Additionally, CYP51-IN-21 effectively inhibits the formation of fungal biofilms, making it a valuable candidate for research in antifungal therapeutics and biofilm-related studies. -
Squalene Synthase Inhibitor
Squalestatin 3 is a potent squalene synthase inhibitor, demonstrating an IC50 of 6 nM. This secondary metabolite, isolated from the fungus Phoma, plays a critical role in regulating the biosynthesis of sterols and terpenes. It is valuable for research applications focused on cholesterol biosynthesis, antifungal research, and the exploration of lipid metabolism pathways. -
Acinar Morphogenesis Inhibitor
Fusarisetin A is a pentacyclic fungal metabolite that functions as an acinar morphogenesis inhibitor. This compound disrupts the normal formation and development of acinar structures in cells, making it a valuable tool for investigating the mechanisms of acinar morphogenesis. Its unique biological activity supports research in developmental biology and tissue engineering. -
α-glucosidase Inhibitor
CM-10-18 is a potent inhibitor of α-glucosidases I and II, demonstrating significant activity in vitro and in animal models. This compound also exhibits antiviral properties by inhibiting dengue virus (DENV) infection in cultured human cells, while effectively reducing peak viremia in mice. CM-10-18 is valuable for research applications related to glycosidase inhibition and viral pathogenesis. -
Mitochondrial Inhibitor
Fusaramin is a mitochondrial inhibitor that demonstrates potent activity against plant pathogenic fungi. It disrupts mitochondrial function, leading to the impairment of fungal growth and viability. This compound is valuable for research applications focused on plant disease management and the study of mitochondrial biology in pathogenic organisms. -
SDH Inhibitor
Inpyrfluxam is a potent inhibitor of succinate dehydrogenase (SDH), specifically targeting the ubiquinone binding pocket of the mitochondrial SDH complex subunits ViSDHB, ViSDHC, and ViSDHD. This inhibition disrupts cellular respiration, demonstrating efficacy in inhibiting conidial germination and mycelial growth of Venturia inaequalis in vitro. Inpyrfluxam is valuable for research studies focused on apple scab and related fungal pathogens. -
HIV-1 Integrase Inhibitor
GSK-1264 is an HIV-1 integrase inhibitor that targets the catalytic core and C-terminal domains of the HIV-1 integrase enzyme. By promoting the formation of an open polymer structure of integrase dimers, GSK-1264 disrupts the late stages of HIV replication and interferes with viral particle assembly. This compound is valuable for research focused on HIV infection and understanding integrase-mediated processes in the viral life cycle. -
HIV-1 Integrase Inhibitor
HIV-1 Integrase Inhibitor 8 is a selective inhibitor targeting the HIV-1 integrase enzyme. It demonstrates potent activity against viral replication by disrupting the integration of viral DNA into the host genome, which is essential for the HIV life cycle. This compound is primarily utilized in research focused on antiretroviral therapy and the development of HIV treatments, contributing to the understanding of integrase inhibition mechanisms. -
HIV-1Integrase Inhibitor
GSK3839919A is a potent allosteric inhibitor of HIV-1 integrase, targeting the enzyme responsible for the integration of viral DNA into the host genome. This compound exhibits significant antiviral activity against HIV-1, making it a valuable tool for research applications focused on the development of novel antiretroviral therapies and the study of HIV replication mechanisms. Its unique mechanism of action may provide insights into resistance pathways and inform drug design strategies. -
HIV Integrase Inhibitor
His-Cys-Lys-Phe-Trp-Trp is an HIV integrase inhibitor, exhibiting an IC50 of 2 μM. This compound impedes the integrase enzyme's function, thereby preventing viral DNA integration into the host genome. His-Cys-Lys-Phe-Trp-Trp is valuable for research focused on HIV pathogenesis and the development of antiretroviral therapies. -
HIV-1 integrase Inhibitor
(S)-BI-1001 is a potent HIV-1 integrase inhibitor, demonstrating significant antiviral activity. It exhibits an IC50 value of 28 nM, an EC50 of 450 nM, and a Kd of 4.7 μM, indicating its efficacy in disrupting viral replication processes. This compound is valuable for research applications focused on HIV-1 pathogenesis and therapeutic development. -
HIV-1 Integrase Inhibitor
HIV-1 Integrase Inhibitor 7 is a potent inhibitor of HIV-1 integrase, exhibiting an IC50 value of 33.3 nM. This compound effectively interferes with the integration of viral DNA into the host genome, making it essential for studies focused on HIV-1 replication and treatment strategies. It serves as a valuable tool in research applications aimed at understanding HIV-1 biology and developing therapeutic interventions against HIV. -
HIV-1 Integrase Inhibitor
HIV-1 Integrase Inhibitor 11 is a potent inhibitor of HIV-1 integrase, demonstrating an IC50 of 125 μM. This compound effectively disrupts the integration of viral DNA into the host genome, thereby hindering the replication process of HIV-1. It is suitable for research applications aimed at developing antiretroviral therapies and studying the mechanisms of HIV integration and resistance. -
HIV-1 IN/RT RNase H Inhibitor
2-Hydroxyisoquinoline-1,3(2H,4H)-dione is an inhibitor of HIV-1 integrase (IN) and reverse transcriptase (RT) ribonuclease H (RNase H), demonstrating IC50 values of 6.32 µM and 5.9 µM, respectively. This compound serves as a valuable tool for studying HIV-1 replication and provides insights into the inhibition mechanisms of viral enzymes. Its biological activity and specificity make it useful for research applications focused on antiviral drug development and understanding HIV-1 pathogenesis. -
HIV Integrase Inhibitor
L-870812 is an HIV integrase inhibitor that targets the strand transfer mechanism of HIV-1 integration. This compound effectively blocks both cell-free and cell-associated HIV-1 infections, demonstrating activity against subtype C and CRFO2_AG primary isolates. L-870812 is suitable for research applications involving replication-deficient HIV-1 Ba-L (env) pseudovirus, facilitating studies aimed at understanding HIV biology and developing therapeutic strategies. -
NF-κB Inhibitor, GPx Inhibitor, HIV Replication Inhibitor
α-MSH (11-13) acetate is a selective melanocortin-1 receptor ligand that functions as an inhibitor of NF-κB, GPx activity, and HIV replication. It induces an acute elevation of intracellular calcium levels under certain costimulation or pathway inhibition conditions. This compound effectively suppresses TNF-α-induced NF-κB activation, inhibits colony formation of Staphylococcus aureus and Candida albicans, and demonstrates potential in the study of infections related to these pathogens, as well as in traumatic brain injury, corneal epithelial wounds, and inflammatory bowel disease research. -
Melanin Biosynthesis Inhibitor
Scytalol A is a selective inhibitor of dihydroxynaphthalene melanin biosynthesis in Lachnellula sp. A32-89, effectively disrupting melanin production without affecting the growth of the organism. This compound is valuable for research investigating melanin biosynthesis pathways and can be utilized in studies focused on fungal pigmentation and its applications in various biotechnological fields. -
Acyltransferase Inhibitor
Amidepsine A is an acyltransferase inhibitor derived from the fungal metabolite of Humicola sp. FO-2942. This compound specifically inhibits the activity of diacylglycerol acyltransferases (DGAT), which play a crucial role in lipid metabolism. Its biological activity makes Amidepsine A a valuable reagent for research applications focused on lipid biosynthesis and metabolic regulation. -
Succinate Dehydrogenase Inhibitor
Flubeneteram is an inhibitor of succinate dehydrogenase, exhibiting an IC50 value of 0.0484 μM. This compound effectively disrupts the activity of succinate dehydrogenase, contributing to its biological activity. Flubeneteram has demonstrated protective effects against fungal pathogens such as Rhizoctonia solani and Sphaerotheca fuliginea in preclinical studies. It is a valuable reagent for research focused on fungal infection mechanisms and potential therapeutic strategies. -
HCV Inhibitor
Roseoside is a potent inhibitor targeting the HCV NS5A/B replicase, demonstrating an IC50 of 20 μM. This compound effectively interferes with HCV RNA replication in vitro and exhibits antibacterial properties against both Gram-positive and Gram-negative bacteria, as well as antifungal activity against Candida albicans. Roseoside serves as a valuable research tool for investigating bacterial infections, candidiasis, and Hepatitis A and C virus mechanisms, while demonstrating no cytotoxic effects in human systems. -
Bacterial Inhibitor
Ethionamide is a second-line anti-tuberculosis agent that acts primarily by inhibiting the synthesis of mycolic acids in Mycobacterium tuberculosis. This compound demonstrates significant antibacterial activity and is effective when administered orally. Ethionamide is utilized in research applications focused on tuberculosis treatment resistance mechanisms and the development of novel therapeutics against mycobacterial infections. -
Bacterial Inhibitor
Fleroxacin is a broad-spectrum fluoroquinolone antibiotic that targets bacterial DNA gyrase and topoisomerase IV, inhibiting bacterial DNA replication and transcription. This compound exhibits potent antibacterial activity against a wide range of gram-negative and some gram-positive bacteria. Fleroxacin is suitable for research applications focused on the elucidation of bacterial resistance mechanisms and the development of novel antimicrobial therapies. -
Bacterial Inhibitor
Nitrofurazone is a nitro-aromatic antibacterial compound primarily targeting bacterial DNA and RNA synthesis. It exhibits broad-spectrum activity against both Gram-positive and Gram-negative bacteria, making it suitable for a variety of microbiological research applications. Nitrofurazone is often utilized in studies assessing antimicrobial resistance and the efficacy of antibiotic treatments. -
Bacterial Inhibitor
Teicoplanin is a glycopeptide antibiotic primarily targeting Gram-positive bacteria, demonstrating potent activity against methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus aureus. In addition to its antibacterial properties, teicoplanin exhibits antiviral effects against HIV-1, SARS-CoV-1, and SARS-CoV-2. This versatile compound is utilized in research related to bacterial resistance and viral infections, making it a valuable tool for studying antimicrobial efficacy and therapeutic interventions. -
Bacterial Inhibitor
Tobramycin is a broad-spectrum aminoglycoside antibiotic that primarily targets bacterial protein synthesis by binding to the 30S ribosomal subunit. It exhibits significant antibacterial activity against a variety of Gram-negative and some Gram-positive bacteria. Tobramycin is particularly effective in research applications focused on infections caused by Pseudomonas aeruginosa, including studies related to pneumonia. Its efficacy makes it a valuable reagent in microbial pathogenesis and antibiotic resistance research. -
Bacterial Inhibitor
Ampicillin sodium is a broad-spectrum beta-lactam antibiotic that targets bacterial cell wall synthesis. It is effective against a wide range of gram-positive and gram-negative bacteria, making it a valuable reagent for microbiological research. Ampicillin sodium is commonly used in cell culture and for selecting genetically modified organisms, as well as in the study of bacterial resistance mechanisms. Its ability to inhibit bacterial growth supports investigations into antibiotic efficacy and microbial interactions. -
Bacterial Inhibitor
Cefoperazone is a semisynthetic cephalosporin that functions as a bacterial inhibitor by interfering with cell wall synthesis. It exhibits a broad spectrum of antibacterial activity against both Gram-positive and Gram-negative bacteria. This reagent is commonly employed in microbiological research to study bacterial infections and assess the efficacy of antimicrobial agents. -
Bacterial Inhibitor
Erdosteine functions as a bacterial inhibitor by inhibiting lipopolysaccharide (LPS)-induced activation of NF-κB. This compound exhibits muco-modulatory, anti-bacterial, anti-inflammatory, and antioxidant properties. Erdosteine is primarily utilized in research applications focused on respiratory disorders and inflammation, supporting the study of therapeutic interventions in these areas. -
Bacterial Inhibitor
Erianin is a bacterial inhibitor that exhibits potent anticancer properties by inhibiting indoleamine 2,3-dioxygenase (IDO). This activity contributes to its ability to suppress tumor angiogenesis, making it a valuable compound in cancer research. Erianin's dual role as an antipyretic and analgesic further broadens its potential applications in therapeutic studies. -
HIV Inhibitor
Sennoside A is an anthraquinone glycoside derived from the senna plant (Cassia angustifolia) that exhibits inhibitory activity against HIV-1. This compound demonstrates an IC50 value of 3.8 μM in preventing HIV-1 replication and effectively inhibits HIV-1 reverse transcriptase-related DNA polymerase and ribonuclease H, with IC50 values of 1.9 μM and 5.3 μM, respectively. Sennoside A serves as a valuable tool in antiviral research, particularly in studies of HIV-1 replication mechanisms and potential therapeutic interventions. -
Bacterial Inhibitor
Allicin (diallyl thiosulfinate) is a potent bacterial inhibitor derived from garlic extracts, primarily responsible for the antimicrobial properties of garlic. It demonstrates significant antimicrobial activity against a wide range of microorganisms, including antibiotic-resistant strains, making it a valuable reagent for research in microbiology and pharmacology. Allicin is commonly utilized in studies investigating natural antibacterial compounds and their mechanisms of action. -
Bacterial Inhibitor
Evoxine, also known as Haplophytin B, is a bacterial inhibitor that selectively targets CO2-induced immunosuppression. It demonstrates significant antimicrobial activity, particularly against common pathogens such as Escherichia coli, Bacillus subtilis, and Staphylococcus aureus, as evidenced by its performance in minimum inhibitory concentration (MIC) assays. Evoxine also inhibits the expression of pro-inflammatory cytokines such as interleukin-6 and chemokine CCL2 in human THP-1 macrophages, indicating its potential utility in therapeutic applications and crude drug preparations, particularly in the context of traditional medicine in West Africa. -
Bacterial Inhibitor
3,3'-Di-O-methylellagic acid is a bacterial inhibitor derived from Euphorbia adenochlora. It selectively inhibits the development of acid-fastness in mycobacteria without affecting their growth rates. Additionally, this compound exhibits hepatoprotective properties, likely attributed to its antioxidative effects, making it valuable for research in microbial resistance and liver health. -
HIV Inhibitor
Gomisin G is a lignan derived from Schisandra chinensis that acts as an anti-HIV agent with an EC50 of 0.006 μg/mL. It exhibits anti-liver cancer and anti-inflammatory properties while utilizing an AKT-cyclin D1 dependent mechanism to target triple-negative breast cancer cells by inhibiting phosphorylation rather than promoting apoptosis. Additionally, Gomisin G leads to G1 phase cell cycle arrest and inhibition of AKT phosphorylation. This compound is suitable for research applications focusing on HIV and various cancer types, including breast and liver cancers. -
HIV Protease Inhibitor
Ganoderic acid B is a triterpene derived from the medicinal mushroom Ganoderma lucidum, functioning as an inhibitor of HIV protease. This compound exhibits moderate inhibitory activity against HIV-1 protease, with an IC50 value of 170 μM, making it a potential candidate for research into antiviral therapies. Additionally, ganoderic acid B has demonstrated the ability to inhibit Epstein-Barr virus (EBV) antigen activation and may serve as a telomerase inhibitor, highlighting its broad potential in virology and cancer research applications. -
Bacterial Inhibitor
Methyl Paraben is a bacterial inhibitor primarily used as a preservative in various applications due to its stability and non-volatility. It has been shown to enhance histamine release and modulate cellular immune responses, in addition to blocking sodium channels. Its properties make it valuable for studies exploring microbial inhibition and the mechanisms of ischemia-reperfusion injury. -
Bacterial Inhibitor
Enrofloxacin is a potent bacterial inhibitor belonging to the fluoroquinolone class. It exhibits an MIC90 value of 0.312 μg/mL against Mycoplasma bovis, demonstrating its effectiveness in combating bacterial infections. This compound is widely utilized in research applications focused on antibiotic resistance, microbiology, and the study of bacterial pathogens. -
Bacterial Inhibitor
Florfenicol is a broad-spectrum antibacterial agent that exerts its effects primarily through inhibition of bacterial protein synthesis. This orally active compound demonstrates additional properties, including anti-inflammatory, pro-apoptotic, and immunomodulatory functions. Florfenicol is commonly utilized in research focused on bacterial infections and the modulation of immune responses. -
Bacterial Inhibitor
Furaltadone hydrochloride is an orally active antibacterial agent targeting bacterial infections. It exhibits in vitro inhibitory effects on Staphylococcus and can be utilized in the study of intestinal Salmonella infections. Additionally, Furaltadone demonstrates potential inhibitory effects on allergic reactions, making it a valuable tool for research in microbiology and immunology. -
Bacterial Inhibitor
Penicillin G sodium salt is a β-lactam antibiotic that inhibits bacterial cell wall synthesis by targeting penicillin-binding proteins. It demonstrates broad-spectrum antibacterial activity against various Gram-positive and some Gram-negative organisms. This reagent is commonly used in microbiological studies to evaluate susceptibility patterns and in the development of antibiotic resistance models. -
Bacterial Inhibitor
Piperacillin sodium is a semisynthetic β-lactam antibiotic that targets penicillin-binding proteins, exhibiting potent bactericidal activity against a broad range of Gram-negative bacteria and select Gram-positive strains. This compound is widely utilized in pharmaceutical research to study bacterial infections and antibiotic resistance. Piperacillin sodium is frequently employed in combination with the β-lactamase inhibitor Tazobactam to enhance its efficacy against resistant bacterial strains.
