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Catalog No.
Product Name
Application
Product Information
Citations
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fungal inhibitor
Antifungal agent 2 is a broad-spectrum fungal inhibitor which inhibits growth of pertinent species of Candida, Cryptococcus, and Aspergillus at a concentration as low as 0.5 μg/mL. -
fungal Cyp51 inhibitor
Quilseconazole (VT-1129) is a potent, orally active fungal Cyp51 (lanosterol 14-α-demethylase) inhibitor, binds tightly to cryptococcal CYP51, but weakly inhibits humans CYP450 enzymes. -
SDHI Inhibitor
Boscalid is a succinate dehydrogenase inhibitor that exhibits significant antifungal activity. By binding to the ubiquinone-binding site of mitochondrial complex II in fungi, Boscalid disrupts ATP production and aerobic respiration, effectively controlling a range of plant fungal diseases, such as gray mold, sclerotinia rot, and powdery mildew. In addition to its agricultural applications, research indicates that Boscalid induces apoptosis and alters lipid metabolism while causing mitochondrial dysfunction, oxidative stress, and ROS accumulation in zebrafish models. Furthermore, it demonstrates chronic toxicity and impacts foraging behavior in honeybees, alongside exhibiting genotoxic and cytotoxic effects in cellular systems. -
Virus Protease Inhibitor
Anthraquinone acts primarily as a viral protease inhibitor, exhibiting multifaceted biological activities including anticancer, anti-inflammatory, diuretic, anti-arthritic, antifungal, antibacterial, antimalarial, and antioxidant properties. This compound plays a crucial role in plant metabolism by impacting the electron transport chain, thereby inhibiting energy transfer during photosynthesis. Additionally, anthraquinone intercalates into DNA and inhibits topoisomerase II, leading to cell death through apoptosis. This diverse profile supports its applications in various fields of chemical and biological research. -
Fungal Inhibitor
Mancozeb is a potent fungicide that operates primarily by inhibiting fungal growth in a variety of agricultural products, including cereals, vegetables, fruits, and ornamental plants. In addition to its antifungal properties, Mancozeb has been shown to activate the Keap1/Nrf2 signaling pathway, leading to liver damage in mice. It alters cellular metabolism through the upregulation of lactate dehydrogenase and cytochrome c, resulting in induced apoptotic pathways, particularly in ovarian cells. This compound is of significant interest in studies related to reproductive toxicity and cellular metabolism. -
Calcineurin Phosphatase Inhibitor
Dibefurin is a potent inhibitor of calcineurin phosphatase, a critical regulator of calcium-dependent signaling pathways. This fungal metabolite has demonstrated significant biological activity in various cellular processes, making it a valuable tool for studying immune response and neuronal signaling. Its application extends to research focused on autoimmune diseases and neurodegenerative disorders, where calcineurin activity plays a pivotal role. -
IMPase Inhibitor
L-671776 is a non-competitive inhibitor of inositol monophosphatase (IMPase), a critical enzyme in the phosphoinositide signaling pathway. This compound, derived from the fungal strain ATCC 20928B, exhibits significant potential for modulating inositol levels and can be utilized in studies investigating mood disorders, neurodegenerative diseases, and other conditions linked to inositol metabolism. Its application in biochemical research can help elucidate the role of IMPase in cellular signaling processes. -
PTP1B Inhibitor
Deoxyfunicone is a potent inhibitor of protein tyrosine phosphatase 1B (PTP1B), demonstrating an IC50 value of 24.3 µM through direct active site binding. This secondary fungal metabolite exhibits notable anti-inflammatory properties, making it a valuable tool for research into metabolic regulation and the treatment of inflammatory diseases. Its mechanism of action positions it as a significant compound for studies focused on diabetes and obesity-related conditions. -
CYP51 Inhibitor
Antifungal agent 136 is an irreversible inhibitor of fungal lanosterol 14α-demethylase (CYP51). It demonstrates potent antifungal activity against drug-resistant strains of Candida albicans and effectively downregulates IL-6 expression. This compound holds potential for research applications in the fields of fungal infection and inflammatory diseases. -
Fungal Inhibitor
Filipin III is a pentaene macrolide antifungal antibiotic featuring a 28-membered ring, primarily derived from various Streptomyces species including S. filipinensis, S. avermitilis, and S. miharaensis. This compound targets membrane sterols, leading to significant alterations in membrane structure, which disrupts fungal cell integrity. Filipin III is widely utilized in research to study fungal infections and to explore mechanisms of antifungal resistance. -
Actin Polymerization Inhibitor
Latrunculin B is an actin polymerization inhibitor commonly derived from marine algae. It modulates the electrophysiological properties of pulmonary veins and has been shown to reduce stretch-induced arrhythmias. Additionally, Latrunculin B exhibits antifungal and antiprotozoal activities, making it a valuable reagent for research in cell biology and pharmacology. -
Fungal Inhibitor
Phenazine-1-carboxylic acid functions as a potent antifungal agent, targeting fungal pathogens effectively. In addition to its antifungal properties, it demonstrates anticancer activity by promoting apoptosis in cancer cells through the modulation of reactive oxygen species (ROS) generation. Phenazine-1-carboxylic acid also influences cytokine expression, upregulating IL-8 and ICAM-1 while inhibiting RANTES and MCP-1 release, indicating potential immunomodulatory effects. This compound is valuable for research in anti-infection strategies, cancer therapy, and immune response modulation. -
Fungal Inhibitor
Sakuranetin is a cherry flavonoid phytoalexin that acts as a potent fungal inhibitor. It exhibits strong antifungal properties, along with notable anti-inflammatory and antioxidative activities. Additionally, Sakuranetin has demonstrated efficacy in ameliorating LPS-induced acute lung injury, making it a valuable compound for research in inflammation and respiratory disorders. -
Tropone Derivatives; Tyrosinase Inhibitor; Virus Inhibitor; Funga Inhibitor
Tropolone is a seven-membered non-benzenoid aromatic compound recognized for its role as a tyrosinase inhibitor, exhibiting an IC50 value of 0.4 μM. This compound demonstrates significant anti-viral and anti-fungal properties, making it effective in a variety of therapeutic applications. Additionally, Tropolone shows enhanced effects when used in conjunction with nucleos(t)ide analogs. Its potential for research in osteosarcoma emphasizes its importance in the exploration of new treatments. -
Antifungal Antibiotic/Complex III Inhibitor
Myxothiazol is an antifungal antibiotic that acts as an inhibitor of mitochondrial electron transport chain complex III (bc1 complex). It demonstrates potent antifungal activity against various yeasts and fungi, exhibiting effective growth inhibition at concentrations ranging from 0.01 to 3 μg/ml. This compound is valuable for research applications focused on mitochondrial function and the mechanisms of antifungal resistance. -
β-1,3-Glucan Inhibitor
Ibrexafungerp is an orally active β-1,3-glucan synthesis inhibitor with demonstrated antifungal properties. Its mechanism targets the cell wall biosynthesis pathway of fungi, making it valuable in research on Candida and Aspergillus infections. This compound is a promising candidate for studies focused on antifungal resistance and the development of new antifungal therapies. -
Ras Inhibitor
(-)-Rasfonin is a natural fungal secondary metabolite that acts as an inhibitor of small G protein Ras. It exhibits significant biological activities, including the induction of apoptosis, necrosis, and autophagy in ACHN cells, a renal carcinoma cell line. This compound is instrumental for research focused on cellular death pathways and therapeutic strategies targeting Ras-mediated signaling in cancer. -
Superoxide Anion Inhibitor
Tanzawaic acid B is a potent inhibitor of superoxide anion production, derived from the fungal source Penicillium citrinum. This compound has been demonstrated to mitigate oxidative stress by targeting superoxide radicals, making it valuable for research in oxidative damage and related pathologies. Its biological activity provides a useful tool for studying the effects of reactive oxygen species in various cellular models. -
Cytochrome P450 Inhibitor
Thujopsene is a potent inhibitor of cytochrome P450 enzymes, specifically targeting CYP2B6, CYP3A4, CYP2C19, CYP2C8, and CYP2C9, with IC50 values of 1.3, 12.6, 13.6, 29.8, and 44.9 μM, respectively. In addition to its role as a metabolic inhibitor, thujopsene binds to PKM2, disrupting cancer cell metabolic pathways and inducing apoptosis in MKN45 cells, thereby demonstrating significant antitumor activity. This compound also exhibits notable anti-termite and antifungal properties through its autoxidation process, broadening its potential applications in both cancer research and pest control. -
FASN Inhibitor
Cerulenin is a potent natural inhibitor of fatty acid synthase (FASN), derived from the fungus Cephalosporium caeruleus. It acts by inhibiting topoisomerase I catalytic activity, consequently enhancing apoptosis induced by SN-38. Cerulenin exhibits both antifungal and antitumor properties, making it a valuable tool for research in cancer therapies and fungal infections. -
Fungal Inhibitor
Dihydrochelerythrine is a natural compound derived from Corydalis yanhusuo, primarily functioning as a fungal inhibitor. This compound exhibits notable antifungal activity, making it a valuable reagent for research applications focused on mycology and the study of fungal infections. Its properties may contribute to the development of novel antifungal therapies. -
Fungal Inhibitor
Cauloside A, a saponin derived from the roots of Dipsacus asper, serves as a potent fungal inhibitor. It exhibits significant antifungal activity, making it a valuable reagent for research focused on fungal pathogenesis and therapeutic interventions. Its effectiveness in combating various fungal strains positions Cauloside A as a crucial tool in the study of antifungal mechanisms and the development of new antifungal agents. -
PI-3 Virus Inhibitor
Tetrahydroepiberberine is an isoquinoline alkaloid derived from Corydalis impatiens. It exhibits significant antifungal properties and demonstrates selective inhibitory effects against the PI-3 virus. This compound is valuable for research applications focused on viral pathogenesis and the development of antiviral therapeutics. -
Tyrosinase Inhibitor
Geranic acid is a tyrosinase inhibitor with demonstrated antifungal properties, exhibiting an IC50 range of 0.14-2.3 mM against mushroom tyrosinase. This compound significantly reduces the viability of human pancreatic cancer cells and B-lymphoma cells, highlighting its potential in cancer research. Additionally, geranic acid effectively inhibits the mycelial growth of maize pathogens such as Colletotrichum graminicola and Fusarium graminearum. It serves as a valuable reagent for studies on fungal infections, pancreatic cancer, and B-lymphoma. -
Fungal Inhibitor
Xanthyletin is a coumarin compound derived from Stauranthus perforatus that acts primarily as a fungal inhibitor. It exhibits notable anti-tumor and antibacterial activities, making it valuable for various research applications in microbiology and cancer studies. Additionally, Xanthyletin effectively inhibits the symbiotic fungus cultivated by leaf-cutting ants, further highlighting its potential in ecological and agricultural research. -
Cytochrome P-450 Inhibitor
Flusilazole is a potent cytochrome P-450 inhibitor with broad-spectrum fungicidal activity. It is commonly employed in research related to fungal infections, providing insights into metabolic pathways and therapeutic interventions. Its mechanism of action offers valuable applications in evaluating and understanding the role of P-450 enzymes in various biological contexts. -
CHS Inhibitor
2,3,5-Tri-O-benzyl-D-ribose is a potent inhibitor of chitin synthase (CHS) in Botrytis cinerea, exhibiting an IC50 value of 1.8 μM. This compound demonstrates significant antifungal activity, capable of inhibiting the B. cinerea BD90 strain with a minimum inhibitory concentration (MIC) of 190 μM. It is valuable for research applications aimed at understanding fungal growth and developing novel antifungal agents. -
Chitinase Inhibitor
Cyclo(Arg-Pro) is a potent chitinase inhibitor that effectively inhibits cell separation in Saccharomyces cerevisiae without compromising its growth. Additionally, Cyclo(Arg-Pro) prevents the morphological transition of Candida albicans from its yeast form to a filamentous state. This compound is valuable for research applications involving fungal morphology and cell separation processes. -
Fungal Inhibitor
Dihydrosanguinarine is a natural compound known for its antifungal properties, primarily acting as a fungal inhibitor. Isolated from the leaves of Macleaya microcarpa, it exhibits significant biological activity against various fungal species. This compound has potential research applications in investigating antifungal mechanisms and exploring its anticancer properties. -
Antifungal/Exosome Inhibitor
Neticonazole is an imidazole derivative that functions as a potent and long-lasting antifungal agent. Its primary mechanism involves inhibiting fungal cell membrane synthesis, making it effective against a variety of fungal infections. Additionally, Neticonazole exhibits anti-infective and potential anti-cancer properties, making it valuable for research applications in both infectious disease and cancer therapy. -
Fungal Inhibitor
Corypalmine is a naturally occurring alkaloid derived from Stephania cepharantha, known for its antifungal properties. It primarily targets fungal cells, inhibiting their growth and proliferation. This compound is useful in various research applications focused on fungal infections and the development of antifungal therapies. -
Fungal Inhibitor
Multifungin (Bromochlorosalicylanilide) is a potent antifungal agent that inhibits fungal growth, making it particularly effective in treating oral candidiasis. This compound disrupts the formation and accumulation of Zearalenone and is effective in reducing fungal populations in stored-crushed corn. Multifungin is valuable for various research applications aimed at understanding fungal infections and developing antifungal therapies. -
CaFBA Inhibitor
FBA-IN-1 is a first-in-class, covalent allosteric inhibitor of fructose-1,6-bisphosphate aldolase (CaFBA) derived from Candida albicans. This compound effectively inhibits the growth of azole-resistant strains with a minimum inhibitory concentration (MIC80) of 1 µg/mL. Its unique mechanism of action positions FBA-IN-1 as a valuable tool in antifungal research, particularly for studying drug-resistant pathogens and exploring new therapeutic avenues. -
Chitin Deacetylase Inhibitor
Benzohydroxamic acid (BHA) is a potent inhibitor of chitin deacetylase (CDA), demonstrating significant antifungal activity. With Ki values of 8.31 μM against CDA from Verticillium dahliae and 9.83 μM against CDA from Puccinia striiformis f. sp. tritici, BHA effectively restores defense responses in infected host plants by upregulating defense-related gene expression. Its application is crucial in research focused on mitigating agricultural fungal diseases, including those caused by Verticillium dahliae and Puccinia striiformis, contributing to the control of cotton wilt and wheat stripe rust. -
Antifungal Agent/HIV-1 Inhibitor
Amphotericin B methyl ester is a methyl ester derivative of the polyene antibiotic Amphotericin B, targeting cell membranes through cholesterol binding. Exhibiting potent antifungal activity, it effectively disrupts the structural integrity of fungal cells. Additionally, Amphotericin B methyl ester has demonstrated the ability to inhibit HIV-1 particle production and replication, making it valuable for research in both antifungal therapies and HIV-1 studies. -
Fungal Gwt1 Enzyme Inhibitor
APX2039 is a potent inhibitor of the fungal Gwt1 enzyme, functioning through its ability to disrupt glycosylphosphatidyl inositol (GPI) anchoring of cell wall mannoproteins. This compound demonstrates significant anticryptococcal activity against Cryptococcus neoformans and Cryptococcus gattii. APX2039 is applicable in research focused on Cryptococcal meningitis (CM) and offers valuable insights into fungal pathogenesis and treatment strategies. -
Fungal Inhibitor
Triflumizole is an imidazole fungicide that functions by inhibiting ergosterol biosynthesis, which is essential for fungal cell membrane integrity. This compound is effective against a range of fungal pathogens, particularly in the management of powdery mildew and scabs on various fruits and crops. It serves as a valuable tool in agricultural research and crop protection strategies. -
Fungal Inhibitor
Viridicatol is a quinolinone alkaloid derived from the fermentation of the endophytic fungus Penicillium sp. R22 in Nerium indicum. This compound exhibits significant antifungal activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 15.6 μg/mL. Viridicatol is suitable for research applications focused on fungal inhibition and antimicrobial activity studies. -
eEF2 Inhibitor
Sordarin sodium is an inhibitor of eEF2, targeting the diphthamide modification essential for its function. By obstructing the binding of eEF2 to the ribosome complex, Sordarin sodium effectively inhibits protein synthesis. Additionally, Sordarin sodium exhibits antifungal activity, making it valuable for research in the fields of microbiology and antifungal drug development. -
Fungal Inhibitor
Cyproconazole is a triazole fungicide that primarily targets fungal pathogens, offering effective protection for crops, fruits, and vegetables. Its biological activity includes the induction of hepatocellular adenomas and carcinomas in CD-1 mice, while demonstrating low toxicity to zebrafish embryos and impacting their locomotor activity. This compound is applicable in agricultural research and studies focused on toxicology and environmental effects of fungicides. -
Fungal Inhibitor
Methyl p-coumarate is an esterified derivative of p-Coumaric acid, functioning primarily as a fungal inhibitor. It exhibits significant inhibition of melanin production in B16 mouse melanoma cells, indicating potential roles in cancer research. Additionally, Methyl p-coumarate demonstrates potent in vitro activity against various pathogens, including Alternaria alternata, making it a valuable reagent for studies in antifungal activity and therapeutic applications. -
Aldolase Inhibitor
Phosphoglycolohydroxamic acid is a potent inhibitor of aldolase and triose-phosphate isomerase, demonstrating significant potential in disrupting metabolic pathways. This compound is primarily utilized in research related to antibacterial and antifungal mechanisms, allowing for the exploration of novel therapeutic strategies against microbial infections. Its ability to inhibit key enzymes positions it as a valuable tool in biochemical studies. -
Fungal Melanization Inhibitor
Coniferin is a glucoside derivative of coniferyl alcohol that functions as a fungal melanization inhibitor. It effectively disrupts the melanin biosynthesis pathway in fungi, making it useful for studies of fungal growth and pathogenicity. Additionally, Coniferin has been shown to inhibit the release of inflammatory mediators such as Prostaglandin E2 and Thromboxane B2, highlighting its potential in research focused on cellular signaling and inflammation. -
Cytochrome bc1 Inhibitor
Inz-5 is a selective inhibitor of the mitochondrial cytochrome bc1 complex, targeting fungal pathogens. This compound effectively impairs fungal virulence and may prevent the development of resistance to antifungal agents. Its unique mechanism of action makes it a valuable tool for research in mycology and antifungal drug development. -
Fungal Inhibitor
Enfumafungin is a triterpene glycoside that acts as a potent fungal inhibitor by targeting (1,3)-beta-D-glucan synthase in the fungal cell wall. This compound exhibits selective antifungal activity against yeasts and filamentous fungi, excluding Cryptococcus, and is not active against Bacillus subtilis. Enfumafungin is valuable for research applications focused on fungal pathogenesis and the development of antifungal therapeutics. -
SDH Inhibitor
SDH-IN-1 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 4.53 μM. This compound demonstrates significant antifungal properties, particularly effective against S. sclerotiorum with an EC50 of 0.14 mg/L. SDH-IN-1 is a valuable tool for researchers studying fungal pathogenesis and metabolism, providing insights into SDH's role in cellular respiration and therapeutic strategies against fungal infections. -
Fungal Inhibitor
Thiophanate-Methyl is a systemic fungicide that targets fungal pathogens by inhibiting mycelial growth and spore germination. This compound exhibits broad-spectrum activity against a variety of fungi, making it useful in agricultural applications for disease management in crops. Its mechanism of action involves the disruption of cellular processes within the target fungi, providing an effective solution for controlling fungal infections in plants. -
Fungal Inhibitor
Deoxylapachol is a significant cytotoxic compound derived from the New Zealand brown alga Landsburgia quercifolia, primarily acting as a fungal inhibitor. It exhibits notable antifungal properties, making it a valuable agent in the study of fungal infections. Additionally, deoxylapachol demonstrates anti-cancer activity, positioning it as a candidate for research applications in oncology and pathogen interaction studies. -
Fungal CYP51 Inhibitor
VT-1598 is an orally active and selective inhibitor of fungal cytochrome P450 51 (CYP51). It exhibits potent antifungal activity against Candida auris, making it a valuable tool for research into fungal infections. Additionally, VT-1598 contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for click chemistry applications, facilitating the study of various biological interactions. -
Antiseptic Agent; Fungal Inhibitor
Hexetidine, an orally active antiseptic agent, exhibits broad-spectrum antibacterial and antifungal activity. It is particularly effective in inhibiting fungal growth, especially when combined with IPBC. At concentrations exceeding 0.1%, hexetidine may lead to oral ulceration; however, it enhances plaque inhibition in conjunction with zinc. Additionally, its efficacy in treating purulent wounds has been demonstrated alongside ultrasound treatment. Hexetidine is a valuable candidate for research focusing on fungal infections and soft tissue purulent-inflammatory conditions.
