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Catalog No.
Product Name
Application
Product Information
Citations
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Parasite Inhibitor
Licoflavone B is a flavonoid derived from Glycyrrhiza inflata, acting as a specific inhibitor of Schistosoma mansoni ATPase and ADPase, with IC50 values of 23.78 µM and 31.50 µM, respectively. This compound demonstrates significant anti-schistosomiasis activity, making it a valuable tool for researchers investigating therapeutic strategies against schistosomiasis. Its mechanism of action and inhibition of key enzymatic pathways underline its potential in parasitic disease research. -
Parasite Inhibitor
Aklomide (2-Chloro-4-nitrobenzamide) is a potent coccidiostat that targets protozoan parasites. Its primary biological activity involves inhibiting the growth and reproduction of coccidia, making it effective in preventing and controlling coccidiosis in poultry, particularly in chickens. Aklomide is valuable for researchers investigating parasite biology and developing strategies for managing coccidial infections. -
Parasite Inhibitor
8-Deoxygartanin, a prenylated xanthone derived from Garcinia mangostana, serves as a selective inhibitor of butyrylcholinesterase (BChE). This compound demonstrates significant antiplasmodial activity, with an IC50 value of 11.8 μM against the W2 strain of Plasmodium falciparum. Additionally, 8-Deoxygartanin inhibits NF-κB (p65) activation, displaying an IC50 of 11.3 μM, making it a valuable reagent for research in parasitic infections and inflammation pathways. -
Parasite Inhibitor
Dibenzosuberol is an effective inhibitor of Trypanosoma thiol reductase (TryR), showing significant biological activity against the parasite T. brucei with an EC50 value of 51.3 μM. This compound serves as a crucial intermediate in the synthesis of various compounds aimed at treating parasitic infections. Its properties make it valuable for research applications targeting trypanosomiasis and related diseases. -
Parasite Inhibitor
ACT-451840 is a potent oral inhibitor specifically targeting Plasmodium falciparum, including both sensitive and resistant strains. This compound demonstrates significant activity against all asexual blood stages of the parasite, characterized by a rapid onset of action. ACT-451840 exhibits a mechanism of action akin to that of artemisinin derivatives, effectively facilitating the elimination of the malaria pathogen. It serves as a valuable research tool for studies related to malaria treatment and resistance. -
SARS-CoV Inhibitor
Ivermectin B1a is a potent inhibitor of SARS-CoV, targeting viral replication. As a derivative of Avermectin B1a, it demonstrates significant antiviral activity and is explored as a potential therapeutic candidate against SARS-CoV-2 and COVID-19. This compound serves as an important tool in research aimed at understanding and combating viral infections. -
Parasite Inhibitor
2',4'-Dihydroxy-6'-Methoxyacetophenone is a phenolic acetophenone that acts as a parasite inhibitor, derived from Artemisia annua. This compound serves as an effective analog of Artemisinin, making it valuable in malaria research. Its properties contribute to the understanding of parasite biology and the development of potential therapeutic strategies against malaria. -
Parasite Inhibitor
Nepodin is a quinone oxidoreductase (PfNDH2) inhibitor derived from Rumex crispus. It exhibits significant antidiabetic and antimalarial activities by stimulating the translocation of GLUT4 to the plasma membrane via AMPK activation. This compound serves as a valuable tool for research into metabolic disorders and parasitic infections, facilitating studies on glucose metabolism and potential therapeutic interventions. -
Parasite Inhibitor
Guanfu base H (Atisinium chloride) is a diterpenoid alkaloid derived from Aconitum coreanum, functioning primarily as a parasite inhibitor. It exhibits significant antiplasmodial activity against the malarial Plasmodium falciparum strains TM4/8.2 (wild type) and K1CB1, exhibiting IC50 values of 4 µM and 3.6 µM, respectively. This compound is a valuable tool for research in malaria treatment and drug development. -
Parasite Inhibitor
1R-cis-Permethrin is a potent insecticide with neurotoxic properties that primarily targets sodium channels in neuronal membranes. By prolonging the activation state of these channels, it disrupts normal neuronal function, resulting in paralysis and death of target pests. This compound is utilized extensively in research for studying the mechanisms of insect neurotoxicity and developing pest control strategies. -
Parasite Inhibitor
Albendazole sulfone is a metabolism-derived compound of Albendazole, primarily targeting parasitic infections. It demonstrates significant anti-parasitic activity against Echinococcus multilocularis metacestodes, making it a valuable reagent for research focused on parasitic diseases and treatment efficacy. Its application extends to studies concerning drug resistance and therapeutic approaches in veterinary and human medicine. -
Parasite Inhibitor
Clofentezine is a potent growth inhibitor with primary activity against acarine pests, specifically targeting mites. This compound effectively disrupts the developmental stages of parasites, making it valuable for research applications in pest control and agricultural science. Its mechanism of action makes clofentezine an important reagent for studying mite population dynamics and developing strategies for management in agricultural settings. -
Parasite Inhibitor
Laetanine is a noraporphine alkaloid derived from Litsea laeta, known for its potent antiplasmodial activity. This compound is also present in the leaf extracts of Phoebe tavoyana (Meissn) Hook. Laetanine is primarily utilized in research applications targeting parasite inhibition, offering potential insights into therapeutic strategies against malaria and related diseases. -
Parasite Inhibitor
Cratoxylone is a potent antiplasmodial agent isolated from the bark of Cratoxylum cochinchinense. It exhibits activity against malaria-causing parasites, making it a valuable tool in the study of parasitic infections. Its biological properties may facilitate research into novel treatments for malaria and enhance understanding of parasite biology. -
Parasite Inhibitor
2-Benzoxazolinone is an anti-leishmanial compound that exhibits an LC50 of 40 μg/mL against Leishmania donovani. This small molecule serves as a versatile building block in chemical synthesis. Additionally, 1,3-Benzoxazol-2(3H)-one derivatives demonstrate significant antimicrobial activity against various Gram-positive and Gram-negative bacteria, as well as yeasts. Certain derivatives have also been identified as effective anti-quorum sensing agents, making them valuable for research applications in microbiology and infectious disease studies. -
Parasite Inhibitor
4′-Hydroxy-2′-methylacetophenone acts as a parasite inhibitor, demonstrating significant ciliate toxicity. This compound effectively inhibits the growth of Tetrahymena pyriformis, with an IC50 value of 0.65 mM. It is a valuable reagent for studies focused on parasitic biology and potential therapeutic applications targeting ciliate organisms. -
Parasite Inhibitor
Fenbendazole analog-1 is an antiparasitic compound that functions by inhibiting rat brain tubulin polymerization. This analog demonstrates significant activity against the protozoa Giardia lamblia and Entamoeba histolytica, as well as the helminth Trichinella spiralis. It serves as a valuable tool for studies focused on parasitic infections and tubulin-targeting therapies. -
SARS-CoV Inhibitor
SARS-CoV-IN-1 is a potent inhibitor of SARS-CoV replication, demonstrating significant antiviral activity with an EC50 of 4.9 μM in Vero cells. Additionally, SARS-CoV-IN-1 displays inhibitory effects on the 3D7 and W2 strains of Plasmodium falciparum, with IC50 values of 15.4 nM and 133.2 nM, respectively. This compound is valuable for research applications focused on both antimalarial and antiviral therapies. -
Parasite Inhibitor
Dodecamethylpentasiloxane acts as a parasite inhibitor, showcasing insecticidal properties specifically against bed bugs. This siloxane compound is utilized in various applications due to its effectiveness in pest management and control. Its unique chemical structure allows it to disrupt the physiological processes of target organisms, making it a valuable reagent in research focused on overcoming insect infestations. -
Parasite Inhibitor
Arprinocid, a purine analog, selectively targets and inhibits the growth of the parasite Toxoplasma gondii in murine models. Its unique mechanism of action interferes with nucleotide metabolism, thereby exhibiting significant antiparasitic activity. This compound is valuable for research applications focused on the pathogenesis and treatment of Toxoplasmosis. -
Parasite Inhibitor
D-Phenothrin is a synthetic pyrethroid classified as a Type II insecticide, primarily targeting insect nervous systems. It exhibits potent insecticidal activity against a variety of pests, including mosquitoes and human lice, making it valuable in both agricultural and veterinary settings. This compound is extensively utilized for pest control in crops and animal husbandry, contributing to effective vector management and enhancing public health. -
Parasite Inhibitor
Tectol is a farnesyltransferase inhibitor, effectively targeting the enzyme in both human and Trypanosoma brucei systems. With IC50 values of 2.09 μM and 1.73 μM respectively, Tectol demonstrates potent antitumor activity against human leukemia cell lines HL60 and CEM. In addition, it exhibits significant inhibitory effects on the drug-resistant strain of Plasmodium falciparum (FcB1), with an IC50 of 3.44 μM, making it a valuable tool for researching parasitic and cancer biology. -
SARS-CoV Inhibitor
Ivermectin B1b is a minor component of Ivermectin with notable activity as a SARS-CoV inhibitor. This compound has demonstrated the ability to inhibit the replication of SARS-CoV-2 in cell culture, making it a valuable reagent for research applications focused on viral infection and antiviral drug development. Its anti-parasitic properties further enhance its relevance in studies addressing a wide range of biological processes. -
PfGSK3/PfPK6 Inhibitor
PfGSK3/PfPK6-IN-1 is a selective inhibitor targeting PfGSK3 and PfPK6, with IC50 values of 97 nM and 8 nM, respectively. This compound effectively inhibits the proliferation of blood-stage Plasmodium falciparum 3D7 parasites, making it a valuable tool for malaria research. Additionally, PfGSK3/PfPK6-IN-1 exhibits low cytotoxicity in hepatocyte cultures at concentrations up to 200 nM, with a significant reduction in cell viability observed at 2 μM. Its dual action enhances its potential in studying malaria-related mechanisms and potential therapeutic strategies. -
Parasite Inhibitor
Melarsonyl, also known as Melarsonic acid, is an anthelmintic agent that targets and inhibits parasitic organisms. It exhibits potent activity against a variety of parasites, making it valuable in research aimed at understanding and combating parasitic infections. This compound is utilized in the study of helminthic diseases and other related areas in parasitology. -
Parasite Inhibitor
Piperazine adipate is an effective anthelmintic agent that targets parasitic worms in mammals. Its broad-spectrum activity makes it suitable for treating various helminth infections, thereby providing significant therapeutic benefits in veterinary and clinical settings. This compound is utilized in research to explore mechanisms of helminth resistance and to develop novel treatment protocols against parasitic infections. -
Parasite Inhibitor
Phosalone is an organophosphate insecticide that primarily targets acetylcholinesterase, leading to the inhibition of neurotransmission in parasites. Its potent biological activity makes it effective in controlling a wide range of insect pests. Phosalone is utilized in entomological research and in studies focusing on pest management strategies and the biochemical pathways of insecticide resistance. -
Parasite Inhibitor
trans-Permethrin is a synthetic pyrethroid that primarily targets the nervous system of insects, functioning as a potent insecticide and neurotoxin. Its primary biological activity involves disrupting sodium channel function, leading to paralysis and death in targeted pest populations. This compound is widely used in research applications aimed at understanding insecticide resistance mechanisms and developing novel pest control strategies. -
Parasite Inhibitor
Bitoscanate, also known as p-Phenylene diisothiocyanate, primarily acts as a parasite inhibitor. It demonstrates significant activity against hookworms, making it valuable in the therapeutic management of parasitic infections. Its biological properties facilitate research applications focused on developing effective treatments for helminthic diseases. -
Parasite Inhibitor
CWHM-1552 is a potent inhibitor of Plasmodium falciparum, demonstrating IC50 values of 51 nM and 53 nM against the 3D7 and Dd2 strains, respectively. This compound exhibits significant efficacy in oral administration and is designed for research applications focused on malaria treatment and parasite biology. CWHM-1552 serves as a valuable tool for studying antimalarial mechanisms and developing novel therapeutic strategies. -
Parasite Inhibitor
Anticancer agent 140 is a compound designed as a parasite inhibitor, exhibiting significant potential for anticancer and antiparasitic activities. This reagent targets specific cellular pathways, making it valuable for research in cancer biology and parasitology. Its effectiveness in inhibiting parasite proliferation underscores its relevance in drug discovery and development for related diseases. -
SDH Inhibitor
Succinate dehydrogenase-IN-2 is a potent inhibitor targeting succinate dehydrogenase (SDH) with an IC50 value of 1.22 mg/L. This compound demonstrates significant antifungal activity, effectively inhibiting a range of fungal pathogens including S. sclerotiorum, V. mali, G. graminis, R. solani, and B. cinerea, with EC50 values in the range of 0.52-3.42 mg/L. It is a valuable tool for research applications focusing on fungal infections and metabolic pathways involving SDH. -
Parasite Inhibitor
Mirincamycin hydrochloride is a potent inhibitor of malaria, specifically targeting the early liver stages of Plasmodium. This compound demonstrates protective effects, effectively preventing the progression of the parasite during its initial infection phase. However, it is important to note that Mirincamycin does not eliminate dormant liver stages, as observed in studies utilizing a rhesus monkey model. This characteristic limits its applicability in certain therapeutic scenarios against malaria. -
Parasite Inhibitor
Allylpyrocatechol is a parasite inhibitor known for its antimalarial activity. This compound has been validated for its efficacy both in vitro and in vivo, demonstrating significant potential in combating malaria. Additionally, structure-activity relationship analyses of its analogs have been conducted, providing insights into the mechanisms underlying its biological effects. Its application in research can contribute to the development of novel antimalarial therapies. -
Parasite Inhibitor
BiPNQ is a potent inhibitor of Trypanosoma cruzi, the protozoan responsible for Chagas disease. This compound effectively disrupts the biological processes of the parasite, making it a valuable tool for research focused on the treatment of Chagas disease and the development of antiparasitic therapies. Its inhibitory activity may help elucidate the mechanisms of infection and potential therapeutic targets. -
Parasite Inhibitor
Ludaconitine, derived from Aconitum spicatum (Bruhl) Stapf, functions as a potent inhibitor of parasites. It demonstrates significant antileishmanial activity, exhibiting an IC50 of 36.10 μg/mL. This compound is valuable for research applications focused on leishmaniasis and the exploration of novel antiparasitic agents. -
Parasite Inhibitor
Ep vinyl quinidine, an epi-vinyl stereoisomer of Quinidine, serves as a targeted inhibitor of parasitic activity. This compound exhibits significant potential in malaria research, leveraging its capabilities as a selective cytochrome P450db inhibitor. Additionally, it functions as a potassium channel blocker with an IC50 of 19.9 μM, positioning it as a valuable tool for investigating anti-parasitic mechanisms and therapeutic interventions. -
Parasite Inhibitor
Antileishmanial agent-1 specifically targets Leishmania parasites, demonstrating potent inhibitory activity against L. amazonensis promastigotes with an IC50 of 15.52 μM and intracellular amastigotes with an IC50 of 4.10 μM. This compound is valuable for research focused on leishmaniasis treatment, facilitating studies on parasite bioenergetics and drug resistance mechanisms. Its ability to effectively inhibit parasite growth makes it a significant tool in the development of antileishmanial therapies. -
HCV Protease Inhibitor
MK-2748 is a potent inhibitor of the hepatitis C virus (HCV) NS3/4A protease. It demonstrates broad-spectrum antiviral activity across all genotypes (gt1a-gt6) with nanomolar potency (IC₅₀ < 0.115 nM), including strong efficacy against drug-resistant mutant strains such as gt1b R155K (IC₅₀ = 0.032 nM) and D168Y (IC₅₀ = 0.057 nM). MK-2748 is valuable for research on HCV infection and contributes to the understanding of antiviral mechanisms and treatment strategies. -
HCV Protease Inhibitor
AL-611 is an inhibitor of the Hepatitis C virus (HCV) NS5B polymerase, demonstrating potent activity with an EC50 value of 5 nM. This compound plays a critical role in antiviral research, particularly in the development of therapeutic strategies against HCV infections. Its effectiveness in inhibiting HCV replication makes it a valuable tool for studies focused on viral RNA synthesis and enzyme interactions. -
HCV Protease Inhibitor
GSK2818713 is a selective Hepatitis C virus (HCV) protease inhibitor that disrupts the replication complex associated with the NS5A protein. This compound exhibits potent anti-HCV activity, making it a valuable tool for studying the replication and life cycle of the virus. GSK2818713 is applicable in research focused on developing therapeutic strategies against Hepatitis C. -
HCV Protease Inhibitor
BI-1230 is a potent inhibitor of the HCV NS3 protease, exhibiting nanomolar activity in blocking viral replication. It demonstrates high selectivity against other serine and cysteine proteases, making it a valuable tool for studying hepatitis C virus infection mechanisms. Additionally, BI-1230 shows favorable pharmacokinetic properties, supporting its potential use in drug development and research applications related to antiviral therapy. -
HCV Protease Inhibitor
MK-6169 is a potent hepatitis C virus (HCV) protease inhibitor that targets the viral NS5A protein. It exhibits broad-spectrum activity against various HCV genotypes, making it a valuable tool for research on antiviral therapies in hepatitis C. This compound is useful for exploring the mechanisms of HCV replication and potential treatment strategies in pharmaceutical development. -
HCV Protease Inhibitor
Isoeuphorbetin is a dimeric coumarin that acts as a potent inhibitor of HCV protease, demonstrated by an IC50 value of 3.63 µg/mL. This compound has significant potential in antiviral research, particularly in the development of therapeutics targeting hepatitis C virus infection. Its ability to effectively block viral protease activity makes it a valuable tool for studying HCV biology and drug discovery. -
HCV Protease Inhibitor
Ac-D-DGla-LI-Cha-C is a potent inhibitor of the hepatitis C virus (HCV) protease, effectively disrupting viral replication. This peptide is instrumental in studying various biological processes and diseases, including cancer, autoimmune disorders, fibrotic conditions, inflammatory responses, neurodegenerative diseases, infectious diseases, lung and cardiovascular disorders, as well as metabolic diseases. Its targeted action on HCV protease makes it a valuable tool for research in virology and therapeutic development. -
HIV-1 Capsid Inhibitor
Lenacapavir is an HIV-1 capsid inhibitor that targets the interface between capsid hexamers and CA monomers, disrupting capsid assembly and viral maturation. This compound inhibits the nuclear translocation of HIV-1 DNA and interferes with CA-mediated protein-protein interactions, resulting in reduced formation of 2-LTR circles and pre-integration proviruses. Additionally, Lenacapavir induces aberrant capsids and decreases the production of mature HIV-1. It demonstrates efficacy against various HIV-1 subtypes and clinical isolates, making it a valuable reagent for research on HIV-1 infection. -
HIV-1 RT Inhibitor
Tenofovir diphosphate disodium is a potent inhibitor of HIV-1 reverse transcriptase, with a Ki value of 1.55 μM for DNA and 0.022 μM for RNA. This compound exhibits key biological activity as an antiretroviral agent, making it a valuable tool for the study of HIV and AIDS. It is suitable for research applications focused on understanding viral replication and developing therapeutic strategies against HIV infection. -
CCR5 Inhibitor
DAPTA is a synthetic peptide that acts as a selective inhibitor of the CCR5 receptor. By blocking CCR5, DAPTA interferes with viral entry into host cells, exhibiting significant anti-HIV activity. This compound is valuable for research in virology and the development of therapeutic strategies against HIV. -
HIV-1 Inhibitor
PYR01 is a non-nucleoside reverse transcriptase inhibitor that targets HIV-1 by activating the death of infected cells. It exhibits significant antiviral activity, demonstrating IC50 values of 27.5 nM and 39.7 nM for cytotoxic and antiviral effects, respectively. By promoting HIV-1 Gag-Pol dimerization and intracellular activation of HIV-1 protease, PYR01 induces selective cytotoxicity in HIV-1-infected cells. This compound is valuable for research focused on HIV biology and therapeutic strategies. -
HIV-1 Inhibitor
PF-3450074 is a specific inhibitor of the HIV-1 capsid protein (CA), exhibiting broad-spectrum antiviral activity against various HIV isolates with submicromolar potency (EC50=8-640 nM). This compound functions at an early stage of the HIV-1 life cycle, impeding viral replication by competing with the binding of nuclear host factors CPSF6 and NUP153. Additionally, PF-3450074 disrupts key processes such as uncoating, assembly, and reverse transcription, making it a valuable tool for HIV research.
