Parasite

Cruzain-IN-1 is a covalent and reversible Cruzain inhibitor, with an IC50 of 10 nM.

JCP174 is a depalmitoylase inhibitor that enhances Toxoplasma host-cell invasion by targeting TgPPT1.

MDK-1088 (T.cruzi Inhibitor) is a Trypanosoma cruzi inhibitor.

Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII).

PK 11195 is a 2?Phenylindolylglyoxylyldipeptide Murine Double Minute (MDM)2/Translocator Protein (TSPO) Dual Inhibitor, and is potentially useful for the Treatment of Gliomas.

SIBA selectively inhibits spermine synthase, IC50=8 uM.

GSK3186899 (DDD-853651) is an inhibitor of cdc-2-related kinase 12 (CRK12), with an EC50 of 1.4 μM for L. donovani in an intra-macrophage assay.

Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication.

Gallinamide A TFA is a potent inhibitor of cathepsin L (CatL), with an IC50 of 17.6 pM. This peptide demonstrates significant antiviral activity by inhibiting SARS-CoV-2 infection, with an EC50 of 28 nM. Additionally, Gallinamide A TFA effectively inhibits Plasmodium falciparum, exhibiting an IC50 of 50 nM, making it a valuable reagent for research into parasitic infections and viral therapies.

CpCDPK1/TgCDPK1-IN-1 is a potent dual inhibitor of CpCDPK1 and TgCDPK1, demonstrating IC50 values of 10 nM and 5.0 nM, respectively. In addition, it shows inhibitory activity against Abl and Src kinases with IC50 values of 75 nM and 65 nM. This compound is suitable for research applications related to toxoplasmosis, providing valuable insights into the therapeutic targeting of these pathways.

Quinacrine acetate is a potent modulator of the cGAS-STING-TBK1 signaling pathway, exhibiting notable immune stimulatory activity. This compound has been investigated for its therapeutic potential in enhancing anti-tumor immunity and improving the efficacy of cancer immunotherapies by addressing the immunogenicity challenges faced by various tumors. Quinacrine acetate also represents a promising approach to mitigate the limitations associated with immune checkpoint inhibitors in cancer treatment.

Albendazole sulfoxide, the principal active metabolite of Albendazole, acts as a potent inhibitor of parasite growth. It demonstrates significant anti-parasitic activity against Echinococcus multilocularis metacestodes, making it valuable in the study of parasitic infections and potential therapeutic interventions. This compound is utilized in research focused on parasitology and drug efficacy against helminthic diseases.

Oxfendazole is a sulfoxide derivative of fenbendazole that targets parasitic organisms through inhibition of energy metabolism. Its primary biological activity is the effective combat against a broad spectrum of parasites. This compound is utilized in research focused on parasitology and can also be studied for its potential effects in tumor promotion investigations.

β-Hederin is a saponin derived from Hedera helix L. (Araliaceae) that demonstrates significant antileishmanial activity. It exhibits IC50 values of 1.5 μM against L. mexicana promastigotes, 68 nM against L. mexicana amastigotes, and 4.57 μM in THP-1 cells. This compound may be utilized in research applications targeting leishmaniasis, providing insights into potential therapeutic strategies against parasitic infections.

Morantel tartrate is an effective anthelmintic agent targeting gastrointestinal parasites. It is primarily utilized in veterinary medicine to control subclinical gastrointestinal parasitism in cattle on pasture. Following administration, morantel tartrate can be detected in ruminal, abomasal, ileal fluids, and feces for up to 98 days, indicating its prolonged activity. This compound is instrumental in research related to parasitic infections and antiparasitic drug development.

SC83288 is an inhibitor of PfDNMT2 in Plasmodium falciparum, with an IC50 of 7 μM. This compound disrupts the epigenetic regulation within malaria parasites, impeding DNA replication and nuclear division, and consequently arrests the development of the asexual blood stage. SC83288 also induces pyknotic morphology in the parasites without impacting cytokinesis post-nuclear division or parasite egress, making it valuable for malaria-related research applications.