MK-0752

Catalog No.: A11194

Gamma-secretase inhibitor

MK-0752

MK-0752 Chemical Structure

CAS NO. 471905-41-6

MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.

Availability: In stock

Package Price Qty
5 mg
$150.00
10 mg
$250.00
50 mg
$550.00
100 mg
$900.00
10mM * 1mL in DMSO
$192.00
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Biological Activity

MK-0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated.
In vitro (25°C) DMSO 85 mg/mL (191.91 mM)
Water Insoluble
Ethanol 43 mg/mL (97.08 mM)
In vivo 30% propylene glycol, 5% Tween 80, 65% D5W 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 22.58 mL 112.89 mL 225.78 mL
0.5 mM 4.52 mL 22.58 mL 45.16 mL
1 mM 2.26 mL 11.29 mL 22.58 mL
5 mM 0.45 mL 2.26 mL 4.52 mL

*The above data is based on the productmolecular weight 442.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11194
Actions Inhibitor
CAS No. 471905-41-6
Formula C21H21ClF2O4S
M. Wt 442.9
Purity >98%
Synonyms MK0752
SMILES C1CC(CCC1CCC(=O)O)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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