Catalog No.
Product Name
Application
Product Information
Citations
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Alkaloid
Luotonin F is an alkaloid extracted from the aerial parts of P. nigellastrum Bunge, known for its inhibitory action on human topoisomerase II. This compound exhibits significant cytotoxic activity against mouse leukemia P-388 cells, making it a valuable tool in cancer research. Its potent biological effects suggest potential applications in the development of novel therapeutic strategies targeting neoplastic diseases. -
Cytochalasan Alkaloid
19-O-Acetylchaetoglobosin A is a cytochalasan alkaloid derived from the fungal metabolite C. globosum, known for its ability to inhibit actin polymerization. This compound exhibits significant cytotoxic activity against HeLa cervical cancer cells, making it a valuable tool for cancer research and the study of cell motility and structure. Its distinct biological properties contribute to investigations in cancer biology and the development of potential therapeutic approaches. -
Water-Soluble Phenolic Acid
Salviamarinic acid A is a water-soluble phenolic acid derived from Salvia miltiorrhiza, known for its potent anti-pulmonary fibrosis activity. This compound enhances cell viability, promotes cell motility, and increases E-cadherin expression while reducing levels of TGF-β1, α-SMA, and Collagen I. Salviamarinic acid A is a valuable tool for research focused on pulmonary fibrosis and related therapeutic investigations. -
Natural Product
p-Coumaroylputrescine is a natural product derived from the callus tissue culture of Nicotiana tabacum. It is known for its potential roles in plant defense mechanisms and stress response regulation. This compound can be utilized in research applications focused on plant physiology, metabolic pathways, and secondary metabolite biosynthesis. -
Natural Product
5-Methyl-5,6-dihydrouridine is a natural product that serves as a minor constituent of chromosomal RNA found in rat ascites tumors. This compound is applied in nucleic acid modification studies, facilitating research on RNA stability and structure. Its unique properties make it relevant for investigations into RNA processing and function in various biological contexts. -
Natural Product
Ganoderic acid T-Q is a natural product derived from Ganoderma lucidum, targeting tubulin polymerization. This compound has been shown to effectively stimulate the assembly of tubulin into microtubules, which are essential for cellular structure and function. Its properties make it a valuable tool in research applications focused on cytoskeletal dynamics and cellular processes. -
Natural Products
Symplostatin 1 is an analogue of Dolastatin 10, derived from the marine cyanobacterium Symploca hydnoides. This compound exhibits significant biological activity with potential applications in cancer research and drug discovery. Its unique structure and mechanism of action make it a valuable tool for investigating cellular processes and exploring natural product derivatives in pharmaceutical development. -
Fungal Alkaloid
Oxaline is a fungal alkaloid derived from Penicillium oxalicum that functions as a potent inhibitor of tubulin polymerization. This inhibition leads to cell cycle arrest at the M phase, making Oxaline a valuable tool for studying cellular processes and the effects of microtubule disruption in various biological systems. Its distinctive mechanism of action positions it as a useful reagent in cancer research and the exploration of novel antifungal therapies. -
Phenolic Acid
Methyl 5-hydroxypyridine-2-carboxylate is a phenolic acid with notable structural characteristics derived from Mahonia fortune. This compound serves as a valuable tool in chemical research, particularly for studies focused on phenolic compounds and their biological roles. While it does not exhibit NO inhibitory effects in vitro, it is an important component for understanding the diverse activities of phenolic acids in various biological contexts. -
Flavonoid
Sanggenon F is a flavonoid compound targeting adipocyte differentiation and nitric oxide production. It effectively inhibits the differentiation of 3T3-L1 adipocytes and reduces nitric oxide production in RAW264.7 cells induced by lipopolysaccharides and IFN-γ, with an IC50 of 19 nM. This compound holds potential for research applications in anti-inflammatory therapies and the management of metabolic diseases. -
Alkaloid
Isomaculosidine is an alkaloid derived from D. dasycarpus known for its ability to inhibit nitric oxide (NO) production. This compound exhibits significant anti-inflammatory activity in lipopolysaccharide (LPS)-stimulated BV2 microglial cells, making it a valuable tool for studying neuroinflammatory processes. Its biological properties make it relevant for research applications focused on neurological disorders and inflammation. -
Natural Products
Multiflorin B is a kaempferol glycoside isolated from the root of the fern Neocheiropteris palmatopedata. It exhibits significant biological activity by inhibiting nitric oxide production, achieving a 52% reduction at a concentration of 20 µg/ml. This compound is valuable for research applications focused on natural products and the study of nitric oxide-related pathways in various biological systems. -
β-carboline Alkaloid
Dichotomine E is a β-carboline alkaloid derived from the root of Stellaria dichotoma var. lanceolata. This compound exhibits significant anti-inflammatory activity by inhibiting nitric oxide (NO) production in lipopolysaccharide (LPS)-treated RAW264.7 cells. Its potential applications include exploring therapeutic strategies for inflammatory conditions and studying the biochemical pathways involved in inflammation. -
Natural Product
Methyl ganoderate H is a natural product derived from Ganoderma lucidum, known for its moderate inhibitory effect on nitric oxide (NO) production. This compound exhibits potential anti-inflammatory activity, making it a valuable tool for research investigating the modulation of inflammatory pathways. Its application may extend to studies involving neuroprotection and cancer biology, where nitric oxide plays a crucial role in cellular signaling. -
Anthraquinone
2,8-Dihydroxy-1-methoxyanthracene-9,10-dione is an anthraquinone known for its biological activity. It exhibits significant antioxidant and anti-inflammatory properties, making it valuable for research in pharmacology and natural product chemistry. This compound is commonly investigated for its potential therapeutic applications, particularly in the development of novel treatments based on traditional medicinal plants. -
Triterpenoid
Canophyllal is a triterpenoid compound isolated from the leaves of Elsholtzia ciliata. This compound exhibits weak inhibition of nitric oxide (NO) production, indicating potential anti-inflammatory properties. Canophyllal is useful in research investigating the modulation of immune responses and the role of NO in various biological processes. -
Natural Product
Angulasaponin B is a natural product derived from Vigna angularis. It primarily inhibits nitric oxide production in LPS-activated RAW264.7 macrophages, demonstrating IC50 values between 13 μM and 24 μM. This compound is valuable for research applications focused on macrophage activation, inflammation, and the modulation of nitric oxide synthesis. -
Sesquiterpenoid Compound
8-Epiasterolide is a sesquiterpenoid compound derived from the rhizomes of Atractylodes japonica Koidzumi. It functions as an inhibitor of nitric oxide (NO) production in lipopolysaccharide (LPS)-treated RAW 264.7 macrophage cells. This compound is valuable for investigating the molecular mechanisms underlying inflammatory diseases and may serve as a potential lead for therapeutic development in related conditions. -
Cassane Diterpenoid
(+)-14-Deoxy-ε-caesalpin is a cassane diterpenoid that functions as a potent inhibitor of nitric oxide (NO) production. It effectively reduces NO release from RAW 264.7 macrophage cells stimulated by lipopolysaccharide (LPS). This compound is useful for studies focused on inflammatory responses and the modulation of nitric oxide signaling pathways in various biological contexts. -
Anti-inflammatory Triterpenoid
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid is an anti-inflammatory triterpenoid that effectively inhibits nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in LPS-stimulated Raw264.7 macrophages. This compound is particularly relevant for research investigating the modulation of inflammatory pathways, making it a valuable tool for studies focused on inflammatory diseases and therapeutic development. Its mechanism of action supports exploration into potential anti-inflammatory therapies. -
Natural Product
Ac-wilforsinine N is a natural product derived from the dried root of Tripterygium wilfordii. This compound has been characterized for its biological activity, although it has shown to be inactive against nitric oxide production in cellular assays. Ac-wilforsinine N is primarily utilized in research focused on inflammatory diseases, contributing to the understanding of potential therapeutic applications in this area. -
Triterpenoid Compound
Bryonolic acid is a bioactive triterpenoid compound that exhibits potent immunomodulatory, anti-inflammatory, antioxidant, and anticancer properties. It is commonly employed in research focused on inflammatory diseases, cancer biology, and oxidative stress. Its diverse biological activities make it a valuable tool for investigating cellular signaling pathways and potential therapeutic applications. -
Diterpenoid
Floridolide B is a clerodane-type diterpenoid derived from the tuberous roots of Tinospora sagittata. This compound exhibits biological activity through the inhibition of nitric oxide (NO) production in LPS-stimulated microglia, with an IC50 value exceeding 60 μM. Its properties make Floridolide B a valuable reagent for research in neuroinflammation and related signaling pathways. -
NO Generation Inhibitor
Triptohypol E is a triterpenoid compound that serves as a nitric oxide generation inhibitor. It is extracted from the leaves of Rhododendron dauricum L. Triptohypol E effectively inhibits nitric oxide production in LPS-stimulated macrophages in a dose-dependent manner, making it a valuable reagent for research in inflammation and immune response. -
Nature Product
(6E)-1,7-Bis(4-hydroxyphenyl)-6-hepten-3-one is a natural product derived from the rhizomes of Curcuma kwangsiensis that functions as an inhibitor of nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated macrophages. This compound exhibits an IC50 value of 8.93 μM, highlighting its potential as a research tool for studying inflammatory pathways. Its biological activity supports investigations into its therapeutic applications in conditions characterized by excessive NO production. -
Alkaloid
Circumdatin C is an alkaloid that demonstrates inhibitory effects on lipopolysaccharide (LPS)-stimulated nitric oxide production. Additionally, it inhibits acetylcholinesterase (AChE) activity with an IC50 value of 13.9 μM. This compound is valuable for research into neurodegenerative diseases, particularly Alzheimer's disease, by exploring mechanisms related to neurotransmitter regulation and neuroinflammation. -
NO Production Inhbitor
3β,7β,15α-Trihydroxy-4-(hydroxymethyl)-11,23-dioxo-lanost-8-en-26-oic acid is a triterpene extracted from Ganoderma lucidum that functions as a nitric oxide (NO) production inhibitor. It effectively reduces NO synthesis in BV-2 microglial cells activated by lipopolysaccharide (LPS), exhibiting an IC50 value of 4.15 μM. This compound is valuable for research applications related to neuroinflammation and the modulation of microglial activation. -
Natural Product
Valeriandoid B is an iridoid compound isolated from the roots of Valeriana jatamansi, a plant known for its traditional medicinal properties. This natural product exhibits various biological activities, including anti-inflammatory and antioxidant effects. Valeriandoid B is being studied for its potential applications in neuropharmacology and herbal medicine, offering insights into its therapeutic benefits on the nervous system. -
Alkaloid
Vomicine is a bioactive alkaloid that targets the cGAS-STING-TBK1 signaling pathway, demonstrating significant anti-inflammatory properties. Isolated from the seeds of Strychnos nux-vomica, vomicine is valuable for research in inflammation-related studies and may contribute to understanding immune responses. Its mechanism of action positions it as a potential candidate for exploring therapeutic interventions in inflammatory diseases. -
Natural Compound
Dehydroperilloxin is a natural compound derived from the dichloromethane extract of Perilla frutescens var. acuta. This compound exhibits potent inhibitory activity against cyclooxygenase-1, with an IC50 value of 30.4 μM. It is primarily utilized in research exploring anti-inflammatory pathways and the modulation of eicosanoid synthesis. -
Natural Product
3,4-Diphenyl-5H-furan-2-one is a natural product derived from the endophytic fungus Aspergillus flavipes AIL8, isolated from the mangrove plant Acanthus ilicifolius. This compound acts as a selective inhibitor of COX-2, demonstrating significant anti-inflammatory and analgesic properties. It serves as a valuable lead compound for research into therapies targeting inflammation and pain-related disorders. -
Flavonoid
Neosakuranin is a flavonoid that targets xanthine oxidase and cyclooxygenase-1 (COX-1), exhibiting a suppressive effect with an IC50 value of 157.8 μM. Isolated from Sorbus commixta and the bark of Prunus cerasus, Neosakuranin demonstrates potential anti-inflammatory activity. This compound is valuable for research in the field of inflammatory diseases, providing insights into its therapeutic potential. -
Natural Product
Picralinal, a triterpenoid compound, is primarily derived from the whole plants of Scilla scilloides. This natural product exhibits significant biological activity, making it valuable in various research applications, including pharmacological studies and investigation of its therapeutic potential. Its unique structural features and biological properties may facilitate the exploration of novel drug candidates derived from natural sources. -
Nitrogen Disaccharide
N-Acetyllactosamine is a nitrogen-containing disaccharide that serves as a galectin-3 inhibitor. It is an essential building block for various oligosaccharides found in glycoproteins and sialyl Lewis X. This compound is also valuable as a precursor in the synthesis of diverse oligosaccharides and exhibits prebiotic effects, making it relevant for research in glycomics and carbohydrate biology. -
Flavonoid Glycoside
Ternatumoside II is a flavonoid glycoside with the ability to stimulate the expression of interferon-gamma (IFN-γ). Isolated from Rhododendron crenulata, it exhibits notable radical-scavenging activities, demonstrating IC50 values of 260.5 μM and 320.2 μM for DPPH and ABTS assays, respectively. This compound is of interest in studies related to antioxidative defense and immune modulation. -
Triterpenoid
Lucidenic acid D is a highly oxidized triterpenoid that primarily targets inflammatory pathways. It exhibits significant anti-inflammatory and antiviral activities, effectively attenuating lipopolysaccharide-induced proinflammatory cytokine and nitric oxide release, while downregulating the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2). Additionally, Lucidenic acid D inhibits the expression of Epstein-Barr virus early antigen in TPA-treated Raji cells, demonstrating potential utility in cancer chemoprevention research. -
Quinazoline alkaloid
Dehydroevodiamine is a key bioactive quinazoline alkaloid derived from Evodiae Fructus, primarily known for its antiarrhythmic properties demonstrated in guinea pig ventricular myocytes. This compound effectively inhibits the expression of lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and nuclear factor-kappa B (NF-κB) in murine macrophage cells. Its diverse biological activities make it a valuable reagent for research focused on cardiovascular function and inflammatory responses. -
Homoisoflavonoid
3,9-Dihydroeucomin is a natural homoisoflavonoid that primarily targets cyclooxygenase enzymes. It exhibits potential biological activity with a focus on modulating COX-2 inhibition. This compound is useful for research applications investigating inflammatory pathways and can contribute to studies on pain management and related therapeutic strategies. -
Natural Compound
Pregomisin is a natural compound derived from the fruits of Schizandra chinensis Baill. It exhibits platelet-activating factor (PAF) antagonistic activity, with an IC50 value of 48 μM. This compound is valuable for research applications focused on inflammatory responses and cardiovascular health. -
Diterpenoid
Epi-cryptoacetalide is a natural diterpenoid that targets the estrogen receptor alpha (ER-α) and the prostaglandin E2 receptor EP2 subtype, demonstrating high affinity with Ki values of 0.3 μM and 1.92 μM, respectively. This compound exhibits anti-endometriosis activity, making it a valuable tool for research in reproductive biology and inflammatory conditions. Its modulatory effects on hormone receptors provide insights into potential therapeutic applications in endometriosis and related disorders. -
Alkaloid
(S)-Laudanosine is an alkaloid with a primary action on the central nervous system and cardiovascular system. It inhibits low-affinity GABA receptors, exhibiting an IC50 value of 10 μM and has the potential to induce seizures, hypotension, and bradycardia. Additionally, (S)-Laudanosine demonstrates analgesic properties through competitive binding to the opioid Mu-1 receptor, with a binding affinity characterized by a Ki value of 2.7 μM. This compound is valuable for research into neurological and cardiovascular functions. -
Alkaloid
Picraline is a natural alkaloid that acts primarily on opioid receptors, exhibiting binding affinities with Ki values of 132 μM for μ-opioid receptors (μOR), 2.38 μM for κ-opioid receptors (κOR), and 98.8 μM for δ-opioid receptors (δOR). It is of significant interest in research focused on opioid signaling pathways, analgesic effects, and potential therapeutic applications in pain management. This compound is valuable for studies exploring the modulation of opioid receptor activity and the related biological responses. -
Natural Product
6-Hydroxyflavanone is a natural product isolated from the leaves of Muntingia calabura that targets cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), as well as opioid and GABA-A receptors. This compound exhibits anti-inflammatory properties and demonstrates potential in alleviating neuropathic pain. Additionally, 6-Hydroxyflavanone is a valuable tool for research into diabetes and related metabolic disorders. -
Naphthoquinone Derivative
Naftazone is a naphthoquinone derivative that primarily targets vascular health. It exhibits protective effects on blood vessels, enhances venous tonicity and capillary resistance, and promotes improved lymphatic and venous circulation. This compound is valuable for research applications focusing on venous insufficiency and related vascular disorders. -
Natural Compound
Ditryptophenaline is a natural compound derived from the metabolites of Aspergillus flavus. It functions as an antagonist of the substance P receptor, demonstrating significant anti-inflammatory activity. This compound is valuable for research focusing on neurogenic inflammation and pain modulation. Its biological properties make it a relevant tool for exploring therapeutic pathways in inflammatory diseases. -
Antispasmodic Opioid Alkaloid
Pargeverine hydrochloride is an antispasmodic opioid alkaloid that primarily targets muscarinic cholinergic receptors, exhibiting a moderate and non-selective blockade. This compound is utilized in research to investigate mechanisms underlying painful spasms and their management. Its application in understanding muscle contraction and relaxation makes it a valuable reagent in pharmacological studies. -
Alkaloid
Frititorine A is a steroidal alkaloid derived from the bulbs of Fritillaria tortifolia. It functions primarily by relaxing acetylcholine-induced tracheal contractions, demonstrating potential as a therapeutic agent in respiratory conditions. This compound is valuable for researchers investigating mechanisms of airway relaxation and potential treatments for asthma-related disorders. -
Bisbenzylisoquinoline Alkaloid Secoderivative
S-Secoantioquine is a bisbenzylisoquinoline alkaloid secoderivative that primarily targets dopamine receptors. It exhibits weak displacement activity on the 3H-SCH 23390 binding site and demonstrates certain displacement activity on the 3H-raclopride binding site in rat striate membrane experiments. This compound is useful for research in neuropharmacology and may aid in understanding the mechanisms of dopaminergic signaling. -
Signature Peptide
IYPTNGYTR is a deamidation-sensitive signature peptide derived from Trastuzumab, specifically designed to provide insights into the metabolic processes of this therapeutic antibody. Its detection allows for the monitoring of Trastuzumab metabolism in vivo, facilitating studies related to drug efficacy and stability. This peptide is valuable for researchers investigating antibody pharmacokinetics and therapeutic applications in oncology. -
Triterpenoid Compound
3β-Hydroxy-oleana-11,13(18)-dien-28-oic acid is a triterpenoid compound with potential anti-inflammatory and hepatoprotective properties. Isolated from Paeonia japonica and peony calli, this compound is recognized for its role as a biotransformation product of oleanolic acid. It may be applied in research focused on exploring natural products for therapeutic agents in various diseases.
