Catalog No.
Product Name
Application
Product Information
Citations
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Natural Product
Aszonalenin is a natural product derived from the metabolite of Aspergillus zonatus. It exhibits significant antimicrobial activity and has been studied for its potential applications in antifungal and antibacterial research. Aszonalenin's unique biochemical properties make it a valuable compound for exploring natural product mechanisms and their therapeutic potential in infectious disease modeling. -
Sulfated phenolic acid
4-(Sulfooxy)benzoic acid is a sulfated phenolic acid that functions as a key metabolite in various biological systems, including C. elegans. This compound is derived from ethyl para-hydroxybenzoate and several flavonoids, playing a role in metabolic processes. It offers potential applications in research focused on metabolic pathways and the biological effects of phenolic compounds. -
Toxic Alkaloid
Jesaconitine is a toxic alkaloid primarily derived from Aconitum species. This compound serves as a significant metabolite detectable in the blood of the right atrium following aconitum poisoning. Jesaconitine is associated with various types of arrhythmia characteristic of aconitine intoxication, making it valuable for research into toxicological effects and mechanisms of cardiac dysrhythmias. -
Alkaloid N-oxide
(2'S)-Nicotine 1-oxide is an alkaloid N-oxide derived from Nicotiana tabacum, commonly known as tobacco. This compound serves as a significant metabolite and exhibits biological activity relevant for research in pharmacology and toxicology. Its applications include studies on nicotine metabolism, receptor interactions, and the exploration of its potential roles in neurobiology. -
Phenolic Metabolite
4-MeCat-2-sulfate is a phenolic metabolite that serves as a key biomarker for dietary polyphenol intake. This compound can be detected in plasma following the consumption of fruit puree, making it valuable for studies on dietary effects and metabolic processes related to fruit consumption. Its analysis can provide insights into human metabolism and the bioavailability of phenolic compounds. Researchers can utilize 4-MeCat-2-sulfate in investigations of dietary influences on health and disease. -
Mycophenolic acid metabolite
Mycophenolic acid acyl-β-D-glucuronide is a metabolite of Mycophenolic acid, primarily functioning through glucuronidation. It plays a crucial role in the pharmacokinetics of Mycophenolic acid, influencing its immunosuppressive efficacy. This compound is essential for studying drug metabolism and the therapeutic monitoring of immunosuppressive regimens in transplantation and autoimmune conditions. -
Crotonaldehyde Metabolite
Dicyclohexylammonium 3-hydroxy-1-methylpropylmercapturic acid is a metabolite of crotonaldehyde, an organic aldehyde primarily involved in various synthetic processes including the production of plastics, pharmaceuticals, and fragrances. This compound serves as a valuable marker for studying the metabolic pathways of crotonaldehyde exposure and is useful in toxicology research. Its application aids in elucidating the biochemical mechanisms through which crotonaldehyde may influence cellular functions and contribute to toxicological effects. -
Disaccharide
D-(+)-Trehalose, an α,α-disaccharide, serves as an effective osmolyte and stress protectant with significant anti-desiccant and cryopreservative properties. This compound is particularly useful in studies related to cellular protection under stress conditions and the transport and storage of carbon. D-(+)-Trehalose is applicable in various research contexts, including food science and pharmaceutical formulation. -
Natural Product
Inosinic acid is a natural metabolite that primarily enhances Umami flavor perception. It plays a significant role in improving the quality and yield of meat products, particularly in livestock such as pigs. Its applications in research extend to studying metabolic pathways and dietary influences on animal growth and product quality. -
Natural Product
D-Erythrose 4-phosphate sodium is a phosphorylated sugar derivative derived from erythrose. It plays a crucial role in cellular metabolism, particularly in the biosynthesis of aromatic amino acids through the shikimic acid pathway. This reagent is widely utilized in biochemical research to study metabolic pathways and enzyme mechanisms involving sugar phosphates. -
Phenolic Aldehyde
Vanillin, a phenolic aldehyde, serves as a versatile building block in chemical research. It is known for its antioxidant properties and is widely used in studies investigating flavor enhancement, fragrance applications, and potential health benefits. Additionally, vanillin has been utilized in the synthesis of diverse compounds, making it valuable in both organic chemistry and pharmaceutical research. -
Phenoloxidase Inhibitor
Phenylthiourea, a phenoloxidase inhibitor, effectively blocks the enzymatic oxidation of DOPA with a Ki value of 0.21 μM. This compound is recognized as a potent inhibitor of tyrosinase, making it valuable in research focused on melanin synthesis and pigmentation processes. Its use can result in observable physiological effects, such as the graying of hair in black rats, highlighting its impact on melanin formation. Phenylthiourea is essential for studies investigating the roles of phenoloxidase and tyrosinase in various biological systems. -
Fucoidan Oligosaccharide Substrate
GDP-L-fucose is a nucleotide sugar that serves as a crucial substrate for the biosynthesis of fucosylated oligosaccharides. It provides the fucose moiety necessary for the assembly of these complex carbohydrates. This compound is synthesized via two distinct pathways: the predominant de novo metabolic route and a secondary salvage pathway. Research has indicated a correlation between GDP-L-fucose levels and diabetes in rat models, highlighting its importance in metabolic studies and potential applications in glycobiology. -
Protein Denaturant/Nucleases Inhibitor
Guanidine thiocyanate is a potent protein denaturant and a strong inhibitor of nucleases. It serves as an effective nucleic acid protector during the extraction of DNA and RNA from cellular materials. This compound is widely utilized in buffers designed for nucleic acid isolation applications, ensuring the integrity and yield of extracted genetic material. -
Furan Terpenoid
(+)-Menthofuran is a furan terpenoid identified in various mint oils. It exhibits notable biological activity and serves as a valuable tool in studies related to flavor and fragrance compounds, as well as in evaluations of its potential therapeutic properties. Research on (+)-Menthofuran may contribute to advances in phytochemistry and natural product development. -
Natural Product
Dihydrosesamin is a lignan derived from the young shoots of Chamaecyparis obtusa cv. Breviramea. This natural product exhibits potential antioxidant properties and may play a role in cellular protection against oxidative stress. It is primarily utilized in research investigating the bioactivity of lignans, as well as their applications in pharmacological studies and natural product chemistry. -
Alkaloid Glycoside
Vicine is an alkaloid glycoside primarily derived from fava beans, known for its role in inducing toxicity in those with a hereditary deficiency in glucose-6-phosphate dehydrogenase. Upon ingestion, vicine is metabolized by intestinal microflora into its active form, divicine, a highly reactive compound that can lead to hemolytic anemia. This compound is essential in studies investigating metabolic disorders and hemolytic conditions. -
Metabolite of Pterostilbene
Pinostilbene is a natural metabolite of Pterostilbene, primarily known for its potential anti-cancer properties. It has demonstrated inhibitory effects on colon cancer cells, making it a valuable compound for cancer research. Pinostilbene's activity may provide insights into cancer treatments and the mechanisms of cell proliferation and apoptosis in colon cancer. -
α-Oxoaldehyde
Glyoxal is a cytotoxic α-oxoaldehyde known for its ability to induce cellular damage and promote protein glycation, leading to the formation of advanced glycation end-products (AGEs). This reagent is particularly relevant for investigating oxidative stress-related diseases, including atherosclerosis, cataracts, and Alzheimer's disease. Additionally, Glyoxal serves as a key compound in research related to the formation of calcium oxalate kidney stones. -
Alkaloid
8-Oxoepiberberine is an alkaloid known for its presence in plasma following the oral administration of Zuojin formula, a traditional Chinese medicine utilized for gastrointestinal disorders. This compound exhibits potential biological activity that may contribute to therapeutic effects on digestive health. Research applications may include exploring its role in gastrointestinal pharmacology and the examination of its metabolic pathways in herbal medicine contexts. -
Natural Product
Cyclosiversioside F 16,25-diacetate is a glycoside derived from the alkaline hydrolysis of its acetyl derivative. This natural product exhibits significant biological activity, making it a valuable compound for research in pharmacology and biochemistry. Its unique structure and properties facilitate investigations into potential therapeutic applications and the exploration of natural product chemistry. -
Polysaccharide
D-(+)-Cellotetraose is a polysaccharide consisting of four glucose units linked by β-1,4-glycosidic bonds. It serves as a primary hydrolysis product of cellulose, providing insights into cellulose degradation processes. This compound is useful in research applications involving enzymatic studies, carbohydrate metabolism, and the investigation of cellulose-derived oligosaccharides' biological functions. -
Alkaloid
11-Desethyl Irinotecan is a camptothecin (CPT) analog and a significant metabolite of irinotecan, targeting topoisomerase I. This compound exhibits potent antitumor activity and is instrumental in cancer research, offering insights into therapeutic applications and metabolism of CPT derivatives. Its pharmacological profile makes it a valuable tool for studying mechanisms of chemotherapy resistance and evaluating efficacy in various cancer models. -
Natural Product
(erythro) 1′,2′-Dihydroxyasarone is a natural product and a metabolite of Beta-asarone, which can be extracted from the roots of Acorus tatarinowii. This compound is known to form glucuronic acid conjugates in vivo, facilitating its excretion in urine. It serves as a valuable marker for studying the metabolism of Beta-asarone and assessing its potential toxic effects. -
Trastuzumab Signature Peptide
FTISADTSK is an endogenous stable signature peptide associated with Trastuzumab, serving as a valuable biomarker for monitoring therapeutic response. This peptide can be utilized in selected reaction monitoring (SRM) assays, facilitating quantitative analysis in oncology research. Its application extends to studies focused on trastuzumab treatment efficacy and patient stratification in breast cancer therapies. -
Natural Product
(25R)-12α-Hydroxyspirost-4-en-3-one is a natural product derived from Hecogenin through the metabolic action of Nocardia globerula. This compound exhibits potential biological activity relevant to the study of plant-derived steroids and their metabolic pathways. It is valuable for research applications focused on the characterization of steroid metabolites and their physiological effects. -
Prasugrel Impurity
Prasugrel chloride impurity is a chemical impurity associated with Prasugrel, extracted from patent US20130345428A1, line 0053. Prasugrel serves as a potent and orally active antagonist of the P2Y12 receptor, effectively inhibiting ADP-induced platelet aggregation. This reagent is useful for research applications related to platelet function and thrombotic disorders, aiding in the assessment of drug purity and compliance in pharmaceutical formulations. -
Natural Product
PD 109488 is a diketopiperazine metabolite derived from quinapril, functioning as a natural product. It exhibits significant biological activity that may be of interest in various research applications, particularly in the study of metabolic pathways and pharmacological profiles of peptide-based compounds. Its structural characteristics make it a valuable tool for exploring the biochemical mechanisms associated with diketopiperazine derivatives. -
Tobacco Alkaloid
(R,S)-Anatabine is a minor alkaloid derived from plants in the Solanaceae family, primarily associated with tobacco. It serves as a specific biomarker for the detection of tobacco consumption. Its biological activity is pivotal in studies focusing on tobacco-related research and the effects of nicotine exposure. -
Natural Plant Growth Regulator
Helminthosporol is a natural plant growth regulator primarily targeting the promotion of seedling development in rice and lettuce. Additionally, it demonstrates the ability to inhibit acyl-CoA: cholesterol acyltransferase (ACAT) activity in rat liver microsomes, thereby affecting cholesterol ester synthesis in macrophages. This compound is valuable for research applications focused on plant physiology and cholesterol metabolism. -
Aldehyde Dehydrogenases Inhibitor
Prunetin is a potent inhibitor of aldehyde dehydrogenases, targeting these enzymes to modulate metabolic processes. This O-methylated isoflavone exhibits significant anti-inflammatory activity, making it useful in the study of inflammatory pathways and related diseases. Its applications extend to research focusing on metabolic regulation and the therapeutic potential of natural compounds in disease models. -
aldehyde dehydrogenase inhibitor
Nitrefazole is a 4-nitroimidazole derivative functioning as a potent inhibitor of aldehyde dehydrogenase (ALDH). It exhibits strong and sustained inhibition of ALDH, an enzyme critical in alcohol metabolism. This compound is valuable for research applications focused on alcoholism, metabolic studies, and pharmacological modulation of ALDH activity. -
Aldehyde Dehydrogenase (ALDH) Inhibitor
S-Methyl-N,N-diethylthiolcarbamate is an effective inhibitor of aldehyde dehydrogenase (ALDH). This compound serves as the active metabolite of the aldehyde dehydrogenase inhibitor disulfiram, generated through the methylation of diethyldithiocarbamate in mouse liver microsomes. S-Methyl-N,N-diethylthiolcarbamate exhibits significant biological activity, demonstrated by its ability to inhibit rat liver low Km ALDH with an ID50 value of 15.5 mg/kg. In vivo studies indicate that a dose of 20.6 mg/kg can reduce mean arterial pressure and elevate heart rate in rats under ethanol stimulation, highlighting its potential applications in cardiovascular and metabolic research. -
Flavonoid
Chrysin-7-O-glucuronide is a flavonoid that targets α-glucosidase and α-amylase, exhibiting inhibitory activity with IC50 values of 612.13 and 980.73 μg/mL, respectively. This compound is known to suppress NF-κB signaling and possesses free radical scavenging abilities, functioning as a protectant for tight junctions and alleviating intestinal mucosal barrier injury. Chrysin-7-O-glucuronide is relevant for research focused on type 2 diabetes and the impacts of severe acute pancreatitis on intestinal health. -
Alkaloid
Lotusine hydroxide is an alkaloid that functions as a signaling pathway modulator and enzyme inhibitor. It exhibits notable inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. Lotusine hydroxide effectively inhibits the EGFR-Akt-ERK signaling pathway by decreasing phosphorylated levels of EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, it enhances antioxidant enzyme activities and is relevant for research on non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder. -
Pseudodisaccharide Moiety
Acarviosin is a pseudodisaccharide moiety that serves as a potent inhibitor of α-amylase. This compound effectively interferes with carbohydrate metabolism by inhibiting starch degradation, making it valuable in research focused on diabetes and obesity. Its activity can aid in elucidating the mechanisms of carbohydrate absorption and regulation in various biological models. -
Triterpenoid Saponin
Ladyginoside A is a triterpenoid saponin derived from the leaves of Polyscias fruticosa. It exhibits inhibitory activity against α-amylase and α-glucosidase, making it relevant for the regulation of carbohydrate metabolism. Additionally, Ladyginoside A shows potential anti-inflammatory properties and may stabilize mast cells. This compound is suitable for investigations into inflammation and metabolic disorders, including diabetes. -
Flavonoids Compound
Kushenol X is a flavonoid compound derived from the roots of Sophora flavescens, known for its inhibition of β-glucuronidase and human carboxylesterase 2 (hCE2). With IC50 values of 2.07 μM and 3.05 μM respectively, it serves as a valuable tool for studying enzymatic pathways and their roles in pharmacokinetics. This compound is relevant for research in drug metabolism and therapeutic interventions involving glycosylated and esterified compounds. -
Natural product
Rosenonolactone is a natural product that primarily inhibits prolyl endopeptidase, thrombin, and cholesterol ester transfer protein. This compound demonstrates significant biological activity, making it useful for studies related to cardiovascular health, blood coagulation, and peptide signaling pathways. Its inhibitory effects on these targets suggest potential applications in drug discovery and development within the fields of metabolism and cardiovascular research. -
Nicotine-related Alkaloid
Nicotelline is a nicotine-related alkaloid that serves as a weak inhibitor of cytochrome P-450 2A6 (CYP2A6), an enzyme involved in the metabolism of coumarin. Although Nicotelline shows limited inhibitory activity at concentrations up to 300 μM, it possesses potential utility as a biomarker for particulate matter (PM) sourced from tobacco smoke. This compound is valuable for research in toxicology and nicotine metabolism studies. -
Natural Product
Danshenxinkun A is a natural product derived from the traditional Chinese medicinal herb Tanshen (Salvia miltiorrhiza). This compound exhibits potential cardioprotective effects, making it a valuable tool for research into heart diseases and related cardiovascular conditions. Its bioactive properties may contribute to understanding the mechanisms underlying cardiac health and disease management. -
Natural Product
Secologanin is a secoiridoid glucoside that serves as a crucial terpenoid intermediate in the biosynthesis of biologically active monoterpenoid indole alkaloids, including reserpine, ajmaline, and vinblastine. The compound is produced through the oxidative cleavage of loganin, catalyzed by secologanin synthase (cytochrome P450 isoform CYP72A1). Secologanin is valuable in research focused on alkaloid biosynthesis and the development of therapeutic agents derived from natural products. -
Oleanolic-type Triterpenoid
β-Amyrenonol, an oleanolic-type triterpenoid derived from licorice roots, serves as a precursor to Glycyrrhetinic acid. This compound exhibits notable anti-proliferative and anti-inflammatory properties, making it relevant in the study of various cellular processes. Its structure also provides a valuable scaffold for the synthesis of numerous triterpenoids, contributing to research in pharmacology and biochemistry. -
Fungal Terpenoid
Terretonin is a fungal terpenoid derived from Aspergillus terreus, primarily targeting enzymatic pathways involved in its biosynthesis. Its production involves a complex sequence of reactions, including oxidation by cytochrome P450 Trt6, isomerization by Trt14, and final processing by the non-heme iron-dependent dioxygenase Trt7. This compound exhibits significant biological activity with potential applications in pharmaceutical research, particularly as a lead for developing novel antifungal agents. -
Alkaloid
Echihumiline is an alkaloid that selectively targets hepatic cytochrome P450 enzymes (CYP450). It is known to induce DNA cross-linking and oxidative stress in hepatocytes, which ultimately contributes to liver necrosis and fibrosis. This compound is a valuable tool for investigating the mechanisms underlying liver diseases and assessing potential therapeutic strategies. -
Natural Product
(R)-Isosakuranetin is a naturally occurring flavanone flavonoid primarily derived from Citrus bergamia. It acts as a selective blocker of the TRPM3 ion channel, which plays a critical role in various physiological processes. This compound has potential applications in research related to pain perception, inflammation, and other TRPM3-associated biological functions. -
Natural Product
Bisandrographolide C is a natural product derived from the plant Andrographis paniculata, characterized as a dimer of ent-labdane diterpenoid. This compound is known to activate TRPV1 and TRPV3 channels, exhibiting Kd values of 289 μM and 341 μM, respectively. Its biological activity includes cardioprotective effects against hypoxia-reoxygenation injury, making it a valuable reagent for research in molecular and cardiovascular studies. -
Natural Product
(-)-Camphor is a natural product derived from the tree Cinnamomum camphora, known for its role as a terpene. This compound exhibits various biological activities, including anti-inflammatory and analgesic effects, making it suitable for research in pharmacology and natural product studies. Its applications extend to the exploration of traditional medicine and the development of therapeutic agents. -
Natural Product
Lepidiline A is a natural product with a specific inhibitory effect on HSD17B1 activity. It demonstrates notable cytotoxicity against HL-60 cells, with an IC50 value of 32.3 μM. Additionally, Lepidiline A enhances the bioconversion efficiency of sex hormones, facilitating the conversion of estrogen into 17β-estradiol and 4-androsten-3,7-dione into testosterone. This compound is of interest for research related to reproductive biology and hormonal modulation. -
Alkaloid
Coccinine is an alkaloid with a primary mechanism as a weak inhibitor of the serotonin transporter (SERT) and P-glycoprotein (P-gp), exhibiting IC50 values of 196.3 μM and 0.96 mM, respectively. This compound displays notable anti-tumor activity across various cancer cell lines, including MCF7, Hs578T, MDA-MB-231 (breast cancer), HCT-15 (colon cancer), and A549 (lung cancer). Coccinine serves as a valuable tool in the research of tumor biology and neurological disorders.
