Catalog No.
Product Name
Application
Product Information
Citations
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Natural Product
Jaconine hydrochloride is a natural product isolated from the honey of Ragwort (Senecio jacobaea). This compound exhibits potential biological activity and is utilized in various research applications, particularly in studies examining the effects of natural products on biochemical pathways and their therapeutic potential. Its unique properties make it a valuable reagent for investigations into the pharmacological effects of plant-derived substances. -
Natural Antioxidant
Indicaxanthin is a natural, water-soluble betalain known for its potent antioxidant properties. It exhibits strong free radical scavenging activity and effectively inhibits lipid peroxidation, thereby reducing malondialdehyde (MDA) formation. Indicaxanthin is relevant for research investigating cardiovascular diseases and diabetes, providing valuable insights into oxidative stress-related mechanisms. -
Phenol
Tribromobisphenol A (Tri-BBPA) primarily targets phenolic compounds. This brominated derivative of bisphenol A exhibits antimicrobial properties and is of interest in studies related to endocrine disruption and environmental toxicology. It is used in various research applications, including assessments of chemical exposure and effects on human health and development. -
Natural Product
Rubrosterone is a natural product and a metabolite derived from insect metamorphosing substances, isolated from the plants Achyranthes rubrofuca and Achyranthes fmaiei (Amaranthaceae). This compound exhibits noteworthy biological activity, making it a valuable tool for biochemical research. Its unique properties facilitate studies in developmental biology and insect physiology, offering insights into metamorphosis and related processes. -
Mesembrine-type Alkaloid
(±)-Δ7-Mesembrenone is a mesembrine-type alkaloid targeting neurotransmitter systems. This compound exhibits significant pharmacological activity, including potential anxiolytic and antidepressant effects, making it valuable for research into mood disorders and stress-related conditions. Its unique chemical profile supports investigations into the therapeutic applications of Sceletium extracts in mental health treatments. -
Brominated Alkaloid
3,5-Dibromo-4-methoxybenzoic acid is a brominated alkaloid known for its role in natural product chemistry. Isolated from marine sponges such as Amphimedon sp. and Psammaplysilla purpurea, this compound exhibits significant biological activity. It is primarily utilized in research related to marine natural products and their potential pharmacological applications. -
Indole Alkaloids
Bufotenidine iodide is an indole alkaloid that acts as a modulator of neurotransmitter pathways. Its primary biological activity is associated with interaction with serotonin receptors, influencing various central nervous system processes. Bufotenidine iodide is commonly used in research focused on neuropharmacology, behavioral studies, and the examination of psychotropic effects in both in vitro and in vivo models. -
Cyclic Oligosaccharide
γ-Cyclodextrin hydrate is a cyclic oligosaccharide that consists of eight glucose units and is derived from bacterial starch digestion. This compound forms water-soluble inclusion complexes with various poorly soluble compounds, enhancing their bioavailability. Its applications span pharmaceuticals and food science, where it is utilized for improving solubility and stability of active ingredients. Additionally, γ-Cyclodextrin hydrate is recognized for its favorable safety profile. -
Natural Compound
2-Hydroxyxanthone is a natural compound derived from Calophyllum inophyllum, classified as an isoprene flavone. It exhibits significant cytotoxic activity against K562 leukemia cells, making it a valuable tool for studying antitumor mechanisms and evaluating its potential in cancer research. This compound can be utilized to further investigate its biological effects and therapeutic applications in various cancer models. -
Nature Product
Acoramone (2,4,5-Trimethoxyphenylacetone) is a natural product derived from phenylpropane, recognized for its role as a key metabolite in biological assays. It has been identified through ^1H NMR analysis of liver microsome incubations from Aroclor 1254-pretreated rats. This compound is useful in research focused on metabolic pathways and the study of biotransformation processes in toxicology and pharmacology. -
Terpenoid
Lucidenic acid E is a terpenoid derived from Ganoderma lucidum, known for its bioactive properties. It exhibits significant anti-inflammatory and antioxidant activities, making it a valuable compound for investigating therapeutic applications in chronic diseases and aging-related disorders. Its unique chemical structure facilitates research into its potential effects on cellular signaling pathways and overall health benefits. -
Triterpenoid Saponin
Platycodin V is a triterpenoid saponin that primarily targets pancreatic lipase. It exhibits a weak inhibitory effect on this enzyme, making it relevant for studies on lipid metabolism and obesity. Researchers may utilize Platycodin V to explore its potential therapeutic applications or to investigate the biochemical pathways associated with lipid digestion and absorption. -
Lipase Inhibitor
Ligupurpuroside A is a competitive inhibitor of lipase, extracted from Ligustrum robustum. This compound demonstrates significant biological activity by modulating lipid metabolism and may be beneficial for research focused on obesity and metabolic disorders. Its inhibitory effects on lipase make it a valuable reagent for studies investigating lipid digestion and absorption. -
Natural Product
Altenusin is a natural product known for its potent DPPH radical scavenging activity. This compound exhibits antioxidant properties, making it a valuable reagent for research in oxidative stress and related biological systems. Altenusin is commonly used in studies investigating potential therapeutic applications in antioxidant defense mechanisms. -
Alkaloid
N-Caffeoyl O-methyltyramine is an alkaloid with demonstrated inhibitory activity against α-glucosidase, exhibiting an IC50 value of 103.58 μM. This compound is derived from Cuscuta reflexa and is relevant for research focused on glucose metabolism and diabetes. Its potential applications include studying carbohydrate absorption and metabolic disorders, making it a valuable reagent in biochemical investigations. -
Natural product
6-Prenylquercetin-3-Me ether is a natural product extracted from the leaves of Glycyrrhiza uralensis. It exhibits potent radical scavenging activity against DPPH, indicating its potential as an antioxidant. Additionally, this compound displays inhibitory activity against α-glucosidase, making it valuable for research in diabetes and metabolic disorders. -
Natural Product
5,4'-Dihydroxy-3,4,3'-trimethoxybibenzyl is a natural product isolated from Dendrobium infundibulum. This compound is primarily investigated for its potential biological activities, although it has been shown to lack inhibitory effects against α-glucosidase and pancreatic lipase. It serves as a valuable tool in research focused on understanding the pharmacological properties of natural compounds and their metabolic implications. -
Natural Product
Timosaponin N is a natural steroidal saponin that acts as an inhibitor of α-Glucosidase. Its primary mechanism involves reducing glucose absorption in the intestine, making it an important research tool in studies related to diabetes and glycemic control. Timosaponin N may provide insights into therapeutic pathways for managing blood sugar levels in diabetic patients. -
Natural Products
α-Glucosidase-IN-35 is a chromene that functions as a potent inhibitor of α-glucosidase, exhibiting an IC50 value of 0.169 mg/mL. Isolated from the aqueous extract of the aerial parts of Brickellia cavanillesii, this compound is valuable in studies targeting carbohydrate metabolism and diabetes research. Its application may facilitate the exploration of α-glucosidase inhibition as a therapeutic strategy in metabolic disorders. -
Natural product
Sumaresinolic acid is a natural product extracted from the root of Heterophyllum species. Its primary mechanism involves the inhibition of alpha-glucosidase, an enzyme implicated in carbohydrate metabolism. This compound exhibits significant biological activity in regulating blood glucose levels, making it valuable for research in diabetes and metabolic disorders. Its potential applications extend to studies on glycemic control and the development of therapeutic agents targeting carbohydrate metabolism. -
α-Glucoside Hydrolase Inhibitor
Adiposin is an α-glucoside hydrolase inhibitor derived from microbial metabolism. This compound exhibits significant biological activity by modulating carbohydrate metabolism, making it a valuable tool in the study of metabolic pathways. It has potential applications in obesity research and the investigation of glycemic control mechanisms. -
Alkaloid
Muramine is an alkaloid derived from the bulbs of Corydalis decumbens. It functions primarily by inhibiting spontaneous Ca2+ oscillations, leading to a reduction in neuronal excitability, with an IC50 value of 13.5 μM. This compound is valuable for research exploring calcium signaling pathways and neuronal activity modulation. -
Indole Alkaloid
Hirsuteine is an indole alkaloid derived from Uncaria rhynchophylla, functioning primarily as a non-competitive antagonist of nicotinic acetylcholine receptors. This compound effectively inhibits nicotine-mediated dopamine release by obstructing ion permeation through receptor channel complexes. Hirsuteine is valuable for research focused on neuropharmacology and the modulation of dopaminergic signaling, particularly in studies related to addiction and neurodegenerative disorders. -
Benzyltetrahydroisoquinoline Alkaloid
(+)-Coclaurine hydrochloride is a benzyltetrahydroisoquinoline alkaloid extracted from various plant sources. This compound exhibits notable anti-aging activity and is utilized in research to explore its potential therapeutic effects. Its unique biological properties make it a valuable tool for studying the mechanisms of aging and related pathways. -
Alkaloid
(±)-Coniine is a piperidine alkaloid known for its function as an nAChR agonist, demonstrating an EC50 of 0.3 mM. This compound exhibits acute toxicity in murine models, with an LD50 value of 7.7 mg/kg. Its unique properties make it valuable for research applications focused on neuromuscular transmission and toxicity studies. -
Polymethoxyflavonoid
3',4',7-Trimethoxyquercetin is a polymethoxyflavonoid identified in Taraxacum mongolicum, and is recognized as a derivative of Quercetin hydrate. This compound exhibits notable anti-tumor activity, making it of significant interest in cancer research. Its potential applications include studies focused on the modulation of signaling pathways implicated in tumor growth and progression. -
Calmodulin Inhibitor
Encecalinol, a calmodulin inhibitor extracted from the aerial parts of Ageratina grandifolia, exhibits significant biological activity through the disruption of calmodulin-mediated signaling pathways. This compound serves as a valuable tool in the study of calcium-dependent processes and can aid in elucidating the roles of calmodulin in various cellular functions. Its application extends to research involving cardiovascular diseases, neurodegenerative disorders, and other conditions where calmodulin plays a critical role. -
Calmodulin Antagonist
Fasciculic acid A is a steroid compound identified as a calmodulin antagonist, extracted from the fungus Hypholoma lateritium. This reagent demonstrates significant anti-inflammatory properties, making it a valuable tool for research focused on calmodulin-related signaling pathways and associated disorders. Its unique activity profile supports various applications in biochemical studies and drug discovery efforts targeting calcium-mediated processes. -
Natural Products
α,β-Thujone is a monoterpene ketone derived from the essential oils of various plants. This compound exhibits a range of biological activities, including neurotoxic effects that can induce seizures at elevated doses. Research applications of α,β-Thujone include studies on its potential carcinogenic properties and its effects on the central nervous system, making it a valuable reagent for investigations into toxicity and pharmacology. -
Alkaloid
Guvacine ethyl ester is an alkaloid derived from the betel nut with a primary mechanism as a GABA uptake inhibitor. It plays a significant role in the modulation of neurotransmitter levels, making it a valuable compound for research on neurological disorders and pharmacological studies related to GABAergic signaling pathways. Its utility in synthetic chemistry further enhances its application in developing novel therapeutic agents targeting the central nervous system. -
Natural Product
Inactone is a natural product that targets the large ribosomal subunit, exhibiting potent inhibitory effects. This bioactive molecule features a unique 3-glutarimidyl group, making it a valuable tool for studying ribosomal function and protein synthesis. Its ability to modulate ribosomal activity positions Inactone as a crucial reagent for research in molecular biology and related fields. -
Active Alkaloid
Wilforgine is a bioactive sesquiterpene alkaloid extracted from Tripterygium wilfordii Hook. F, primarily targeting calcium receptors or channels in muscle tissues. This compound has been shown to induce significant microstructural and ultrastructural alterations in the muscles of Mythimna separata larvae, making it a valuable tool for research into muscle physiology and insect neurobiology. Its unique activity profile positions Wilforgine as a potential candidate for studies focused on muscle function and pharmacological modulation in insects. -
Diterpene Dialdehyde
(-)-α-Eudesmol is a diterpene dialdehyde known for its neuroprotective properties. It has demonstrated efficacy in mitigating acute brain injury induced by diethylnitrosamine. This compound is valuable in neurological research, particularly in studies focused on oxidative stress and its impact on neuronal health. -
Aldehyde Dehydrogenases Inhibitor
Prunetin is a potent inhibitor of aldehyde dehydrogenases, targeting these enzymes to modulate metabolic processes. This O-methylated isoflavone exhibits significant anti-inflammatory activity, making it useful in the study of inflammatory pathways and related diseases. Its applications extend to research focusing on metabolic regulation and the therapeutic potential of natural compounds in disease models. -
aldehyde dehydrogenase inhibitor
Nitrefazole is a 4-nitroimidazole derivative functioning as a potent inhibitor of aldehyde dehydrogenase (ALDH). It exhibits strong and sustained inhibition of ALDH, an enzyme critical in alcohol metabolism. This compound is valuable for research applications focused on alcoholism, metabolic studies, and pharmacological modulation of ALDH activity. -
Aldehyde Dehydrogenase (ALDH) Inhibitor
S-Methyl-N,N-diethylthiolcarbamate is an effective inhibitor of aldehyde dehydrogenase (ALDH). This compound serves as the active metabolite of the aldehyde dehydrogenase inhibitor disulfiram, generated through the methylation of diethyldithiocarbamate in mouse liver microsomes. S-Methyl-N,N-diethylthiolcarbamate exhibits significant biological activity, demonstrated by its ability to inhibit rat liver low Km ALDH with an ID50 value of 15.5 mg/kg. In vivo studies indicate that a dose of 20.6 mg/kg can reduce mean arterial pressure and elevate heart rate in rats under ethanol stimulation, highlighting its potential applications in cardiovascular and metabolic research. -
Flavonoid
Chrysin-7-O-glucuronide is a flavonoid that targets α-glucosidase and α-amylase, exhibiting inhibitory activity with IC50 values of 612.13 and 980.73 μg/mL, respectively. This compound is known to suppress NF-κB signaling and possesses free radical scavenging abilities, functioning as a protectant for tight junctions and alleviating intestinal mucosal barrier injury. Chrysin-7-O-glucuronide is relevant for research focused on type 2 diabetes and the impacts of severe acute pancreatitis on intestinal health. -
Alkaloid
Lotusine hydroxide is an alkaloid that functions as a signaling pathway modulator and enzyme inhibitor. It exhibits notable inhibitory activity against α-amylase and α-glucosidase, with IC50 values of 30.60 μg/mL and 36.15 μg/mL, respectively. Lotusine hydroxide effectively inhibits the EGFR-Akt-ERK signaling pathway by decreasing phosphorylated levels of EGFR, Akt, and ERK, leading to apoptosis, G0/G1 cell cycle arrest, and reduced cancer cell proliferation. Additionally, it enhances antioxidant enzyme activities and is relevant for research on non-small cell lung cancer, type 2 diabetes, and autism spectrum disorder. -
Pseudodisaccharide Moiety
Acarviosin is a pseudodisaccharide moiety that serves as a potent inhibitor of α-amylase. This compound effectively interferes with carbohydrate metabolism by inhibiting starch degradation, making it valuable in research focused on diabetes and obesity. Its activity can aid in elucidating the mechanisms of carbohydrate absorption and regulation in various biological models. -
Triterpenoid Saponin
Ladyginoside A is a triterpenoid saponin derived from the leaves of Polyscias fruticosa. It exhibits inhibitory activity against α-amylase and α-glucosidase, making it relevant for the regulation of carbohydrate metabolism. Additionally, Ladyginoside A shows potential anti-inflammatory properties and may stabilize mast cells. This compound is suitable for investigations into inflammation and metabolic disorders, including diabetes. -
Flavonoids Compound
Kushenol X is a flavonoid compound derived from the roots of Sophora flavescens, known for its inhibition of β-glucuronidase and human carboxylesterase 2 (hCE2). With IC50 values of 2.07 μM and 3.05 μM respectively, it serves as a valuable tool for studying enzymatic pathways and their roles in pharmacokinetics. This compound is relevant for research in drug metabolism and therapeutic interventions involving glycosylated and esterified compounds. -
Natural product
Rosenonolactone is a natural product that primarily inhibits prolyl endopeptidase, thrombin, and cholesterol ester transfer protein. This compound demonstrates significant biological activity, making it useful for studies related to cardiovascular health, blood coagulation, and peptide signaling pathways. Its inhibitory effects on these targets suggest potential applications in drug discovery and development within the fields of metabolism and cardiovascular research. -
Nicotine-related Alkaloid
Nicotelline is a nicotine-related alkaloid that serves as a weak inhibitor of cytochrome P-450 2A6 (CYP2A6), an enzyme involved in the metabolism of coumarin. Although Nicotelline shows limited inhibitory activity at concentrations up to 300 μM, it possesses potential utility as a biomarker for particulate matter (PM) sourced from tobacco smoke. This compound is valuable for research in toxicology and nicotine metabolism studies. -
Natural Product
Danshenxinkun A is a natural product derived from the traditional Chinese medicinal herb Tanshen (Salvia miltiorrhiza). This compound exhibits potential cardioprotective effects, making it a valuable tool for research into heart diseases and related cardiovascular conditions. Its bioactive properties may contribute to understanding the mechanisms underlying cardiac health and disease management. -
Natural Product
Secologanin is a secoiridoid glucoside that serves as a crucial terpenoid intermediate in the biosynthesis of biologically active monoterpenoid indole alkaloids, including reserpine, ajmaline, and vinblastine. The compound is produced through the oxidative cleavage of loganin, catalyzed by secologanin synthase (cytochrome P450 isoform CYP72A1). Secologanin is valuable in research focused on alkaloid biosynthesis and the development of therapeutic agents derived from natural products. -
Oleanolic-type Triterpenoid
β-Amyrenonol, an oleanolic-type triterpenoid derived from licorice roots, serves as a precursor to Glycyrrhetinic acid. This compound exhibits notable anti-proliferative and anti-inflammatory properties, making it relevant in the study of various cellular processes. Its structure also provides a valuable scaffold for the synthesis of numerous triterpenoids, contributing to research in pharmacology and biochemistry. -
Fungal Terpenoid
Terretonin is a fungal terpenoid derived from Aspergillus terreus, primarily targeting enzymatic pathways involved in its biosynthesis. Its production involves a complex sequence of reactions, including oxidation by cytochrome P450 Trt6, isomerization by Trt14, and final processing by the non-heme iron-dependent dioxygenase Trt7. This compound exhibits significant biological activity with potential applications in pharmaceutical research, particularly as a lead for developing novel antifungal agents. -
Alkaloid
Echihumiline is an alkaloid that selectively targets hepatic cytochrome P450 enzymes (CYP450). It is known to induce DNA cross-linking and oxidative stress in hepatocytes, which ultimately contributes to liver necrosis and fibrosis. This compound is a valuable tool for investigating the mechanisms underlying liver diseases and assessing potential therapeutic strategies. -
Natural Product
(R)-Isosakuranetin is a naturally occurring flavanone flavonoid primarily derived from Citrus bergamia. It acts as a selective blocker of the TRPM3 ion channel, which plays a critical role in various physiological processes. This compound has potential applications in research related to pain perception, inflammation, and other TRPM3-associated biological functions. -
Natural Product
Bisandrographolide C is a natural product derived from the plant Andrographis paniculata, characterized as a dimer of ent-labdane diterpenoid. This compound is known to activate TRPV1 and TRPV3 channels, exhibiting Kd values of 289 μM and 341 μM, respectively. Its biological activity includes cardioprotective effects against hypoxia-reoxygenation injury, making it a valuable reagent for research in molecular and cardiovascular studies.
