Natural Products

Diosgenin glucoside, a saponin compound extracted from Tritulus terrestris L., provides neuroprotection by regulating microglial M1 polarization. Diosgenin glucoside protects against spinal cord injury by regulating autophagy and alleviating apoptosis .

Ryanodine is a cell permeant ryanodine receptor modulator. Ryanodine can either stimulate or inhibit Ryanodine-mediated Ca2+ release depending on its concentrations. Poisonous diterpenoid found in Ryania speciosa.

Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death.

Coumarin 7 can be used as a laser dye.

Coumarin 30 is useful as laser dye. Efficient laser dye for pulsed and CW operation.

Armillarisin A is a regulator and promotor of immune functions. It acts by enhancing the role of macrophages, inhibiting bacteria growth, improving the protein metabolism, and regulating liver function.

Ligustilide, a main lipophilic component of Danggui (Chinese Angelica root, Radix Angelica sinensis), alleviates brain damage and improves cognitive function in rats of chronic cerebral hypoperfusion.

Puromycin Aminonucleoside is an aminonucleoside antibiotic that blocks protein synthesis in both prokaryotes and eukaryotes by causing premature termination of nascent polypeptide chains.

Sauristolactam, a natural aristolactam isolated from aerial portions of Saururus chinensis, has significant neuroprotective activity against glutamate-induced toxicity in primary cultured rat cortical cells.

Harringtonin is an alkaloid isolated from Cephalotaxus harringtonia, and an antitumor agent.

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.1 It potently inhibits the activation of Epstein-Barr virus by phorbol esters (IC50 = 140 nM).

Cyclosporin C is a highly lipophilic cyclic peptide natural product, a member of the cyclosporin series of antifungal and immunosuppresive compounds - Cyclosporin A and B. The cyclosporins bind the cyclophilin intracellular proteins, highly conserved proteins involved in cis-trans isomerization of peptidyl-prolyl bonds and protein folding.

Hygromycin B is an aminoglycoside antibiotic isolated from Streptomyces hygroscopicus. It acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.

Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.

Clobetasol is a topical corticosteroid, glucocorticoid, and antiinflammatory.

Meisoindigo, a derivative of Indigo naturalis, is a promising agent with in vitro and in vivo activity against human acute myeloid leukemia.

Dynemicin A is an antitumor natural product isolated from Micromonospora chersina which causes DNA strand cleavage.

Proscillaridin A is a cardiac glycoside first isolated from plants in the genus Scilla.

Marizomib is a naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity.

Fusicoccin is a toxin originally extracted from Fusicoccum amygdali Del.

XPhos is an organophosphorus compound derived from biphenyl.

Afzelin is a flavonol glycoside. It is the rhamnoside of kaempferol. It is found in Nymphaea odorata.

Wiskostatin is a cell-permeable N-alkylated carbazole derivative that selectively blocks actin filament assembly. The compound acts as a selective, reversible inhibitor of N-WASP (neural Wiskott Aldrich syndrome protein), a signal integrating protein. Wiskostatin also binds to N-WASP, stabilize the autoinhibited conformation and prevent the activation of Arp2/3 (actin-related protein 2/3) complex.

Trichodesmine is a pyrrolizidine alkaloid that has neurotoxic effects and is naturally found in Crotolaria argyptiaca, a shrub plant that is native to the south eastern desert of Egypt.

Psoralen is a CovA photochemical probe in studies of DNA mutation and repair mechanisms.

Nitrarine 2HCl is a hypotensive? spasmolytic? coronary dilator? sedative in experimental arrhythmias. in experimental arrhythmias in the cat? caused by calcium chloride? Aconitine and electric cardiac stimulation? Nitrarine dihydrochloride presents a hypotensive? spasmolytic? coronary dilating and sedative action. Its antiarrhythmic properties are due to its stabilizating effects on the membrane and its coronary dilating action. Nitrarine dihydrochloride is 3-4 times as potent as Novocainamide and Quinidine? and the duration of its effect is 2-5 times longer than that of these products.

Lycoctonine is a plant alkaloid and a precursor to the ABC ring system of taxoids.

20-Hydroxyecdysone is an ecdysteroid hormone produced in arthropod species that induces developmental changes associated with ecdysis and the completion of metamorphosis.

Graveoline isolated from ethanolic extract of Ruta graveolens.

Fraxinellone is an insecticidal agent, inhibiting growth of larvae, used in the treatment and protection of crops and produce. Also, a naturally occurring compound used in the treatment of tumors.

Diacetylkorseveriline is an antiarrhythmic (classes i and iv)? belonging to a novel structural class. effective against arrhythmia caused by aconitine? cacl2? electric stimulation of the ventricles or ligature of the aorta, recommended dose for one cycle of experiment on mice: 3.0-30.0 mg/kg? intravenously.

Delsoline is a nicotinic receptor antagonist, ganglion blocker, exhibits weak affinity at brain ??-bungarotoxin-sensitive nicotinic acetylcholine receptors.

Betonicine can be found in herbs and spices and pulses, which makes betonicine a potential biomarker for the consumption of these food products. Betonicine can be found primarily in urine. This compound belongs to the class of organic compounds known as l-alpha-amino acids.

Lupeol is a dietary triterpene found in certain fruits, vegetables, and medicinal plants. It has potent anti-inflammatory, anticarcinogenic, antimutagenic, and antimalarial activity.

Hederagenin, a triterpenoid saponin, is used to study the properties of triterpenoid saponins as biopesticides that prevent fungal growth, bacterial growth, and viral plant diseases.

Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (Devil??s Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort).

Ginsenoside Rh1 displays hypoallergenic and antiinflammatory properties.

Rifamdin is a Rifamicyn derivative with therapeutic effect on pulmonary tuberculosis.

Mitragynine is an indole alkaloid from the plant Mitragyna speciosa. It has stimulatory, antinociceptive, and opiate-like effects, acting through noradrenergic, serotonergic, and opioid receptors

Nimbolide is a terpenoid lactone derived from Azadirachta indica (Neem tree) that displays a variety of biological activities including anti-malarial and anticancer activity.

Desacetylnimbin is a new limonoid from Arisaema decipiens, a traditional antitumor herb.

Triacsin C, originally isolated from Streptomyces sp., is an inhibitor of long fatty acid acyl-CoA synthetase (IC50 = 6.3 uM in Raji cells).

Protostemonine (PSN) is the main anti-inflammatory alkaloid extracted from the roots of Stemona sessilifolia (known as ?€?Baibu?€? in traditional Chinese medicine).

8-Gingerol is a bioactive ingredient of ginger (Zingiber officinale) having anti-nausea, anti-inflammatory, and anti-carcinogenic properties.

Mesaconitine is one of the Aconitum sp. alkaloids, compounds that exist in an extensive variety of plant species.

Typhaneoside is found in ginkgo nuts.

Linderane, isolated from Lindera strychnifolia vill., is the first example of a ten-membered monocyclic sesquiterpenic lactone.

Cinnamaldehyde is the organic compound that gives cinnamon its flavor and odor.

Cinnamyl alcohol is an organic compound that is found in esterified form in storax, Balsam of Peru, and cinnamon leaves.

Ophiopogonin D is a new phenylpropanoid glycoside from Ophiopogon japonicus Ker-Gawl.